1-Indanone is the
organic compound
Some chemical authorities define an organic compound as a chemical compound that contains a carbon–hydrogen or carbon–carbon bond; others consider an organic compound to be any chemical compound that contains carbon. For example, carbon-co ...
with the formula C
6H
4(CH
2)
2CO. It is one of two isomeric benzocyclopentanones, the other being
2-indanone. It is a colorless solid. 1-Indanone is a substrate for the enzyme
indanol dehydrogenase.
Preparation
It is prepared by oxidation of
indane
Indane or indan is an organic compound with the formula C9H10. It is a colorless liquid hydrocarbon. It is a petrochemical, a bicyclic compound. It occurs at the level of about 0.1% in coal tar. It is usually produced by hydrogenation of inde ...
or
indene
Indene is an aromatic, polycyclic hydrocarbon with chemical formula . It is composed of a benzene ring fused with a cyclopentene ring. This flammable liquid is colorless although samples often are pale yellow. The principal industrial use of i ...
. It can also be prepared by cyclization of
phenylpropionic acid.
:
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Uses
1-Indanone is an intermediate in the synthesis of a variety of pharmaceutical drugs including
2-aminoindane (using beta-keto-oxime formation with isoamylnitrite followed by reduction),
drinidene,
pirandamine,
[I. Jirkovsky, L. G. Humber and R. Noureldin, Eur. J. Med. Chem., 11, 571 (1976)] and
pyrophendane.
References
Aromatic ketones
{{ketone-stub