The physiome of an individual's or

species A species () is often defined as the largest group of organisms in which any two individuals of the appropriate sexes or mating types can produce fertile offspring, typically by sexual reproduction. It is the basic unit of Taxonomy (biology), ...

physiological Physiology (; ) is the science, scientific study of function (biology), functions and mechanism (biology), mechanisms in a life, living system. As a branches of science, subdiscipline of biology, physiology focuses on how organisms, organ syst ...

state is the description of its functional behavior. The physiome describes the physiological dynamics of the normal intact

organism An organism is any life, living thing that functions as an individual. Such a definition raises more problems than it solves, not least because the concept of an individual is also difficult. Many criteria, few of them widely accepted, have be ...

and is built upon information and structure (

genome A genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as ...

proteome A proteome is the entire set of proteins that is, or can be, expressed by a genome, cell, tissue, or organism at a certain time. It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions. P ...

, and morphome). The term comes from "physio-" (nature) and "-ome" (as a whole). The study of physiome is called

physiomics Physiomics is a systematic study of physiome in biology. Physiomics employs bioinformatics to construct networks of physiological features that are associated with genes, proteins and their networks. A few of the methods for determining individual r ...

. The concept of a physiome project was presented to the

International Union of Physiological Sciences The International Union of Physiological Sciences, abbreviated IUPS, is the global umbrella organization for physiology. IUPS aims to facilitate initiatives that strengthen the discipline of physiology. IUPS is a scientific union member of the ...

(IUPS) by its Commission on

Bioengineering Biological engineering or bioengineering is the application of principles of biology and the tools of engineering to create usable, tangible, economically viable products. Biological engineering employs knowledge and expertise from a number ...

in Physiology in 1993. A workshop on designing the Physiome Project was held in 1997. At its world congress in 2001, the IUPS designated the project as a major focus for the next decade. The project is led by the Physiome Commission of the IUPS. Other research initiatives related to the physiome include: *The EuroPhysiome Initiative *The NSR Physiome Project of the National Simulation Resource (NSR) at the

University of Washington The University of Washington (UW and informally U-Dub or U Dub) is a public research university in Seattle, Washington, United States. Founded in 1861, the University of Washington is one of the oldest universities on the West Coast of the Uni ...

, supporting the IUPS Physiome Project *The Wellcome Trust Heart Physiome Project, a collaboration between the

University of Auckland The University of Auckland (; Māori: ''Waipapa Taumata Rau'') is a public research university based in Auckland, New Zealand. The institution was established in 1883 as a constituent college of the University of New Zealand. Initially loc ...

and the

University of Oxford The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest un ...

, part of the wider IUPS Physiome Project

References

External links

National Resource for Cell Analysis and Modeling (NRCAM)
Biophysics Physiology {{biophysics-stub

See also

References

External links