Interleukin 10 receptor, beta subunit is a subunit for the

interleukin-10 receptor Interleukin-10 receptor (IL-10R) is a type II cytokine receptor. The receptor is tetrameric, composed of 2 α and 2 β subunits. The α subunit (encoded in the ''Il10ra gene)'' is expressed on haematopoietic cells (such as T, B, NK, mast, and d ...

. IL10RB is its human

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. IL10RB has also been designated CDw210b (

cluster of differentiation The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophe ...

w210b). The protein encoded by this gene belongs to the

cytokine receptor Cytokine receptors are receptors that bind to cytokines. In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly be ...

family. It is an accessory chain essential for the active

interleukin 10 receptor Interleukin-10 receptor (IL-10R) is a type II cytokine receptor. The receptor is tetrameric, composed of 2 α and 2 β subunits. The α subunit (encoded in the ''Il10ra gene)'' is expressed on haematopoietic cells (such as T, B, NK, mast, and d ...

complex. Coexpression of this and

IL10RA Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. ''IL10RA'' is its human gene. IL10RA has also been designated CDw210a (cluster of differentiation w210a). Function The protein encoded by this gene is a rec ...

proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, ''

IFNAR2 Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the ''IFNAR2'' gene. Function The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons a ...

'', ''

IFNAR1 Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the ''IFNAR1'' gene. Function The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for type I interfer ...

'', and ''

IFNGR2 Interferon gamma receptor 2 also known as IFN-γR2 is a protein which in humans is encoded by the ''IFNGR2'' gene. Function This gene (''IFNGR2'') encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-g ...

'', form a

class II cytokine receptor Type II cytokine receptors, also commonly known as class II cytokine receptors, are transmembrane proteins that are expressed on the surface of certain cells. They bind and respond to a select group of cytokines including interferon type I, i ...

gene cluster located in a small region on chromosome 21.

References

Further reading