Hui Zhang () is a professor of Pathology at

Johns Hopkins University The Johns Hopkins University (often abbreviated as Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland, United States. Founded in 1876 based on the European research institution model, J ...

. She specializes in analysis of glycoproteins and other protein modifications on the proteome scale. Her most cited article is ''Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry''.

Biography

Education and career

Zhang earned her B.S. (1989) and M.S. (1992) from

Peking University Peking University (PKU) is a Public university, public Types of universities and colleges in China#By designated academic emphasis, university in Haidian, Beijing, China. It is affiliated with and funded by the Ministry of Education of the Peop ...

, and her Ph.D. (1999) from the

University of Pennsylvania The University of Pennsylvania (Penn or UPenn) is a Private university, private Ivy League research university in Philadelphia, Pennsylvania, United States. One of nine colonial colleges, it was chartered in 1755 through the efforts of f ...

. Zhang joined

New England Biolabs New England Biolabs (NEB) is an American life sciences company which produces and supplies recombinant and native enzyme reagents for life science research. It also provides products and services supporting genome editing, synthetic biology and ...

and Cell Signal Technology and was promoted to senior scientist. After working with proteomics and glycoproteomics with Dr.

Ruedi Aebersold Rudolf Aebersold (better known as Ruedi Aebersold; born September 12, 1954) is a Swiss biologist, regarded as a pioneer in the fields of proteomics and systems biology. He has primarily researched techniques for measuring proteins in complex samp ...

at the

Institute for Systems Biology Institute for Systems Biology (ISB) is a non-profit research institution located in Seattle, Washington, United States. ISB concentrates on systems biology, the study of relationships and interactions between various parts of biological systems, ...

for five years, she joined Johns Hopkins University as an assistant professor in 2006. She was promoted to an associate professor in 2011 and a full professor in 2016.

Research

At Johns Hopkins, Zhang is director of the Mass Spectrometry Core Facility that she established at the Center for Biomarker Discovery and Translation. Her research studies protein modification on the proteome scale and the effects of modification on protein function and the progression of diseases. Her focus has been on developing high-throughput technologies "to isolate and identify two of the most abundant protein modifications - phosphorylation and glycosylation." Zhang applies proteomics technologies to determine protein modifications associated with cancer, which may improve early detection and monitoring of therapeutic care. In addition, she is looking into new methods to study protein modifications that may have major implications for a wide range of other health issues. Zhang is identified as the inventor of five U.S. patents dating from 2001 to 2007. https://scholar.google.com/citations?user=ununaGsAAAAJ&hl=en

Selected works

https://scholar.google.com/citations?user=ununaGsAAAAJ&hl=en *Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou J, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Chen L, Wang J, Shah P, Cha S-W, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Choi C, Monroe ME, Thomas S, Moore RJ, Yu K-H, Tabb DL, FenyoÌˆ D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih I-M, Pandey A, Zhang B, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD, and the CPTAC investigators. Deep proteogenomic characterization of human ovarian cancer. ''Cell''. 2016; 166: 755–765. *Sun S, Shah P, Toghi Eshghi S, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti NU, Zhang Z, Chan DW, Zhang H*. Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. ''Nature Biotechnology''. 2016; 34: 84-88 *Shah P, Wang X, Yang W, Toghi Eshghi S, Sun S, Hoti N, Pasay J, Rubin A, Zhang H*. Integrated proteomic and glycoproteomic analyses of prostate cancer cells reveals glycoprotein alteration in protein abundance and glycosylation. ''Molecular & Cellular Proteomics''. 2015; 14: 2753–2763. *Toghi Eshghi S, Shah P, Yang W, Li X, Zhang H*. GPQuest: A Spectral Library Matching Algorithm for Site-Specific Assignment of Spectra from Tandem Mass Spectrometric Analysis of Intact Glycopeptides. ''Analytical Chemistry''. 2015; 87: 5181–5188. *Zhang, H., Li, X. J., Martin, D. B., and Aebersold, R. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. ''Nature Biotechnology'' (2003) 21:660. *Zhang, H., Zha, X., Tan, Y., Hornbeck, P. V., Mastrangelo, A. J., Alessi, D. R., Polakiewicz, R. D., and Comb, M. J. Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs. ''Journal of Biological Chemistry'' (2002) 277:39379.

References

{{DEFAULTSORT:Zhang, Hui Living people 1960s births Year of birth missing (living people) American pathologists Chinese pathologists American women biologists Chinese women biologists Chinese emigrants to the United States Peking University alumni University of Pennsylvania alumni American women academics 21st-century American women scientists Johns Hopkins School of Medicine faculty