Howard Yuan-Hao Chang (

traditional Chinese A tradition is a system of beliefs or behaviors (folk custom) passed down within a group of people or society with symbolic meaning or special significance with origins in the past. A component of cultural expressions and folklore, common examp ...

: 張元豪; born 1972) is a Taiwanese-American

physician-scientist A physician-scientist (in North American English) or clinician-scientist (in British English and Australian English) is a physician who divides their professional time between direct clinical practice with patients and scientific research. Physicia ...

and is the senior vice president of research and chief scientific officer of

Amgen Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical Corporation, company headquartered in Thousand Oaks, California. As one of the world's largest independent biotechnology companies, Amgen has a ...

. He was previously the Virginia and D. K. Ludwig Professor of Cancer Genomics and of Genetics at the

Stanford University School of Medicine The Stanford University School of Medicine is the medical school of Stanford University and is located in Stanford, California, United States. It traces its roots to the Medical Department of the University of the Pacific, founded in San Fra ...

. He is best known for his research with long non-coding RNAs. a principal investigator at the

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American busin ...

Biography

Chang was born in Taipei, Taiwan, to a Taiwanese family of physicians. His father,

Chang Chau-hsiung Chang Chau-hsiung (; born 3 February 1942) is a Taiwanese physician and politician. He served as the vice-chairman of People First Party from 2000 to 2016. Early life and education Born in Takao Prefecture, Taiwan, Empire of Japan, Chang was a ...

, was a Taiwanese physician and politician. Chang earned a bachelor's degree in biochemistry from

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

and completed a Ph.D. in biology at the

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of moder ...

(MIT) and earned a

Doctor of Medicine A Doctor of Medicine (abbreviated MD, from the Latin language, Latin ) is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the ''MD'' denotes a professional degree of ph ...

(M.D.) at

Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...

as part of the "Harvard-MIT physician scientist training program" working in

David Baltimore David Baltimore (born March 7, 1938) is an American biologist, university administrator, and 1975 Nobel Prize in Physiology or Medicine, Nobel laureate in Physiology or Medicine. He is a professor of biology at the California Institute of Tech ...

's laboratory. He did his dermatology residency and postdoctoral training at Stanford with Patrick O. Brown. After starting his own lab, his group discovered unexpected transcriptional activity for noncoding DNA and identified

HOTAIR HOTAIR (for HOX transcript antisense RNA) is a human gene located between HOXC11 and HOXC12 on chromosome 12. It is the first example of an RNA expressed on one chromosome that has been found to influence the transcription of the HOXD cluste ...

which further confirmed the importance of

long non-coding RNA Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as mic ...

Awards

* 2015 - Paul Marks Prize for Cancer Research * 2017 - Elected to the

National Academy of Medicine The National Academy of Medicine (NAM), known as the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Engineerin ...

* 2018

NAS Award in Molecular Biology The NAS Award in Molecular Biology is awarded by the U.S. National Academy of Sciences "for recent notable discovery in molecular biology by a young scientist who is a citizen of the United States." It has been awarded annually since its inception ...

for "discoveries of long noncoding RNAs and technologies unveiling the noncoding genome." * 2018 - Investigator,

* 2020 - Elected to the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

* 2020 - Elected to the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...

* 2024 - Lurie Prize in Biomedical Sciences * 2024 -

King Faisal Prize The King Faisal Prize (, formerly King Faisal International Prize), is an annual award sponsored by King Faisal Foundation presented to "dedicated men and women whose contributions make a positive difference". The foundation awards prizes in fiv ...

in Biology, * 2024 -

Stanley J. Korsmeyer Award The American Society for Clinical Investigation (ASCI), established in 1908, is one of the oldest and most respected medical honor societies in the United States. Organization and purpose The ASCI is an honorary society to which more than 2,800 p ...

* 2024 -

Albany Medical Center Prize The Albany Medical Center Prize in Medicine and Biomedical Research is the United States' second highest value prize in medicine and biomedical research, awarded by the Albany Medical Center. Among prizes for medicine worldwide, the Albany Medical ...

jointly with

Adrian R. Krainer Adrian Robert Krainer is a Uruguayan-American biochemist and molecular geneticist known for his research into RNA gene-splicing. He helped create a drug for patients with spinal muscular atrophy. Krainer holds the St. Giles Foundation Profess ...

and Lynne E. Maquat.Albany Medical Center Prize 2024
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References

{{DEFAULTSORT:Chang, Howard Y. 1972 births Living people Scientists from Taipei 21st-century American physicians Taiwanese emigrants to the United States Harvard Medical School alumni Massachusetts Institute of Technology School of Science alumni Fellows of the American Academy of Arts and Sciences Members of the National Academy of Medicine Stanford University School of Medicine faculty Amgen American people of Taiwanese descent Members of Academia Sinica