Howard Rasmussen (1925–2005) was an American physician-scientist known for his research on

aldosterone Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. It plays ...

and

insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabol ...

secretion.

Early life and education

Howard Rasmussen was born March 1, 1925, in

Harrisburg, Pennsylvania Harrisburg ( ; ) is the capital city of the U.S. commonwealth of Pennsylvania and the seat of Dauphin County. With a population of 50,099 as of 2020, Harrisburg is the ninth-most populous city in Pennsylvania. It is the larger of the two pr ...

, to Frederick Rasmussen and Faith Elliott. He grew up on a Pennsylvania dairy farm with five brothers. As a young man, he served in the United States military in

World War II World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the wo ...

in Europe, earning a

Purple Heart The Purple Heart (PH) is a United States military decoration awarded in the name of the president to those wounded or killed while serving, on or after 5 April 1917, with the U.S. military. With its forerunner, the Badge of Military Merit, ...

with an

oak leaf cluster An oak leaf cluster is a ribbon device to denote preceding decorations and awards consisting of a miniature bronze or silver twig of four oak leaves with three acorns on the stem. It is authorized by the United States Armed Forces for a spec ...

. At the war's conclusion, Rasmussen attended

Gettysburg College Gettysburg College is a Private college, private Liberal arts colleges in the United States, liberal arts college in Gettysburg, Pennsylvania. Founded in 1832, the campus is adjacent to the Gettysburg Battlefield. Gettysburg College has about ...

, earning a

Bachelor of Science A Bachelor of Science (BS, BSc, B.S., B.Sc., SB, or ScB; from the Latin ') is a bachelor's degree that is awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Scienc ...

in 1948. He then went on to medical school at

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

, earning his medical degree in 1952, followed by training in

internal medicine Internal medicine, also known as general medicine in Commonwealth nations, is a medical specialty for medical doctors focused on the prevention, diagnosis, and treatment of diseases in adults. Its namesake stems from "treatment of diseases of ...

Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is a teaching hospital located in the West End neighborhood of Boston, Massachusetts. It is the original and largest clinical education and research facility of Harvard Medical School/Harvar ...

. Rasmussen then spent 1955–1956 as a research fellow at

University College London University College London (Trade name, branded as UCL) is a Public university, public research university in London, England. It is a Member institutions of the University of London, member institution of the Federal university, federal Uni ...

, before returning to the US to pursue a

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

– which he was awarded by

Rockefeller University The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and pro ...

in 1959.

Academic career

Following his PhD, Rasmussen stayed for a short time at Rockefeller as an

assistant professor Assistant professor is an academic rank just below the rank of an associate professor used in universities or colleges, mainly in the United States, Canada, Japan, and South Korea. Overview This position is generally taken after earning a doct ...

, before being hired away by the

University of Wisconsin, Madison A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Univ ...

as an

associate professor Associate professor is an academic title with two principal meanings: in the North American system and that of the ''Commonwealth system''. In the ''North American system'', used in the United States and many other countries, it is a position ...

in 1961. He later moved again to join the faculty of the

University of Pennsylvania The University of Pennsylvania (Penn or UPenn) is a Private university, private Ivy League research university in Philadelphia, Pennsylvania, United States. One of nine colonial colleges, it was chartered in 1755 through the efforts of f ...

as the Benjamin Rush Professor and Chair of Biochemistry. In 1976, Rasmussen moved to

Yale University Yale University is a Private university, private Ivy League research university in New Haven, Connecticut, United States. Founded in 1701, Yale is the List of Colonial Colleges, third-oldest institution of higher education in the United Stat ...

where he served as Professor of Medicine and Cell Biology as well as Chief of the Endocrinology and Metabolism section at Yale Medical School. In 1993, Rasmussen moved to the

Medical College of Georgia The Medical College of Georgia (often referred to as MCG) is the medical school of Augusta University, the state's only public medical school, and one of the top 10 largest medical schools in the United States. Established in 1828 as the Medical ...

to found and direct the Institute of Molecular Medicine and Genetics. He retired in 2000. Rasmussen was named a fellow of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is a United States–based international nonprofit with the stated mission of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsib ...

in 1985.

Research

Rasmussen's research focused on hormone signaling, particularly

parathyroid hormone Parathyroid hormone (PTH), also called parathormone or parathyrin, is a peptide hormone secreted by the parathyroid glands that regulates serum calcium and phosphate through its actions on the bone, kidneys, and small intestine. PTH incre ...

, and

. He was among the first to appreciate the role of

calcium Calcium is a chemical element; it has symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar to it ...

as a cellular

second messenger Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers. (Intercellular signals, a non-local form of cell signaling, encompassing both first m ...

Personal life

Rasmussen married Jane Spence in 1952, and they remained married until her death in 1999. They had four children. He died on April 20, 2005, in Charlotte, North Carolina following a prolonged illness.

References

{{DEFAULTSORT:Rasmussen, Howard American physiologists 1925 births 2005 deaths Gettysburg College alumni Harvard Medical School alumni Rockefeller University alumni University of Wisconsin–Madison faculty Perelman School of Medicine at the University of Pennsylvania faculty Yale School of Medicine faculty