A histamine agonist is a drug which causes increased activity at one or more of the four
histamine receptor
The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand. Histamine is a neurotransmitter involved in various physiological processes. There are four main types of histamine recep ...
subtypes.
H
1 agonists promote wakefulness.
H
2:
Betazole
Betazole (also known as ametazole) is a histamine H2 receptor agonist. Betazole hydrochloride is known as gastramine and histalog.
It has been used as a gastric stimulant to test for maximal production of gastric secretion activity. The test ...
and
Impromidine
Impromidine (INN) is a highly potent and specific histamine H2 receptor agonist.
It has been used diagnostically as a gastric secretion indicator.
See also
* Histamine agonists
A histamine agonist is a drug which causes increased activity ...
are examples of agonists used in diagnostics to increase histamine.
H
3:
Betahistine
Betahistine, sold under the brand name Serc among others, is an anti-vertigo medication. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms. It was first registered in Europe in 1970 for the treatment of Ménière's ...
is a weak Histamine
1 agonist and a very strong antagonist of the Histamine
3 autoreceptor
An autoreceptor is a type of Receptor (biochemistry), receptor located in the cell membrane, membranes of neuron, nerve cells. It serves as part of a negative feedback loop in signal transduction. It is only sensitive to the neurotransmitters or ...
. Antagonizing H
3 increases histaminergic tone.
See also
*
Histamine antagonist
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides r ...
References
External links
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