was a Japanese pharmacologist and chemist. He was known for his discovery of EPR effect. He published more than 650 papers in reputed journals; the

h-index The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scientist or scholar. The ''h''-index correlates with success indicators such as winning t ...

is 115 (

Google scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of Academic publishing, scholarly literature across an array of publishing formats and disciplines. Released in Beta release, beta in November 2004, th ...

, ).

Education and career

Maeda studied at

Tohoku University is a public research university in Sendai, Miyagi, Japan. It is colloquially referred to as or . Established in 1907 as the third of the Imperial Universities, after the University of Tokyo and Kyoto University, it initially focused on sc ...

with a bachelor's degree in 1962, at the

University of California, Davis The University of California, Davis (UC Davis, UCD, or Davis) is a Public university, public Land-grant university, land-grant research university in Davis, California, United States. It is the northernmost of the ten campuses of the University ...

with a master's degree in 1964, and a doctorate in 1967 at Tohoku. He was a post-doctoral at the Sidney Farber Cancer Institute of

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

from 1967 to 1971, he also acquired the medical doctorate there. From 1971 to 1980 he was an assistant professor at

Kumamoto University , abbreviated to ''Kumadai'' (熊大), is a Japanese national university located in Kumamoto, Kumamoto Prefecture in the Kyushu region of Japan. It was established on May 31, 1949, at which time the following institutions were subsumed into it; ...

and became a professor from 1980.

Research

Maeda developed the neocarzinostatin "SMANCS" with a copolymer of

styrene Styrene is an organic compound with the chemical formula C6H5CH=CH2. Its structure consists of a vinyl group as substituent on benzene. Styrene is a colorless, oily liquid, although aged samples can appear yellowish. The compound evaporates easi ...

and

maleic acid Maleic acid or ''cis''-butenedioic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. Its chemical formula is HO2CCH=CHCO2H. Maleic acid is the ''cis'' Cis–trans isomerism, isomer of butenedioic acid, ...

in 1979. Afterward, Maeda and his student Yasuhiro Matsumura discovered the

Enhanced permeability and retention effect The enhanced permeability and retention (EPR) effect is a controversial concept by which molecules of certain sizes (typically liposomes, nanoparticles, and macromolecular drugs) tend to accumulate in tumor tissue much more than they do in normal t ...

(ERP effect) of macromolecular drugs in 1986, which laid an important foundation for the cancer-targeted therapy (CAncer Stromal Targeting; CAST).

Recognition

Maeda was awarded Princess Takamatsu Cancer Research Fund Prizes, Commemorative Gold Medal of E.K.Frey-E.Werle, Life Time Achievement Award of

Royal Pharmaceutical Society The Royal Pharmaceutical Society (RPharmS or RPS) is the body responsible for the leadership and support of the pharmacy profession (pharmacists) within England, Scotland, and Wales. It was created along with the General Pharmaceutical Council ...

, CRS College of Fellows Award, Nagai Innovation Award for Outstanding Achievement (2013), and

Clarivate Citation Laureates Clarivate Citation Laureates, formerly Thomson Reuters Citation Laureates, is a list of candidates considered likely to win the Nobel Prize in their respective field. The candidates are so named based on the citation impact of their published rese ...

(2016).前田浩 Hiroshi Maeda , Chem-Station (ケムステ)
/ref> He was also a member of

Controlled Release Society Control may refer to: Basic meanings Economics and business * Control (management), an element of management * Control, an element of management accounting * Comptroller (or controller), a senior financial officer in an organization * Controlling ...

References

External links

Biography on the occasion of a lecture at the 9th Drug Delivery Summit 2016
{{DEFAULTSORT:Maeda, Hiroshi 1938 births 2021 deaths Japanese pharmacologists Japanese immunologists People from Hyōgo Prefecture Scientists from Hyōgo Prefecture Tohoku University alumni University of California, Davis alumni Academic staff of Sojo University Harvard University faculty Academic staff of Kumamoto University