Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (, ''mannosidase II'', ''exo-1,3-1,6-alpha-mannosidase'', ''alpha-D-mannosidase II'', ''alpha-mannosidase II'', ''alpha1-3,6-mannosidase'', ''GlcNAc transferase I-dependent alpha1,3
lpha1,6annosidase'', ''Golgi alpha-mannosidase II'', ''ManII'', ''1,3(1,6)-alpha-D-mannosidase'', ''1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
''(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase''. This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and break ...
:
Hydrolysis
Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution, elimination, and solvation reactions in which water is the nucleophile.
Biological hydrolysis ...
of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-
oligosaccharide
An oligosaccharide (/ˌɑlɪgoʊˈsækəˌɹaɪd/; from the Greek ὀλίγος ''olígos'', "a few", and σάκχαρ ''sácchar'', "sugar") is a saccharide polymer containing a small number (typically two to ten) of monosaccharides (simple sug ...
Man5(GlcNAc)3
This enzyme is involved in the synthesis of
glycoprotein
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as g ...
s. It is a key enzyme of
N-linked Glycan
The terms glycans and polysaccharides are defined by IUPAC as synonyms meaning "compounds consisting of a large number of monosaccharides linked glycosidically". However, in practice the term glycan may also be used to refer to the carbohydrate ...
processing and is inhibited by small molecule
swainsonine
Swainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a potential chemotherapy drug. As a toxin in locoweed (likely its primary toxin) it also is a significant cause of econo ...
.
[van den Elsen, J.M., Kuntz, D.A., Rose, D.R., "Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells", ''European Molecular Biology Organization Journal'', 20(12): 3008–3017.]
References
External links
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EC 3.2.1