History
The name "Cellosolve" was registered in 1924 as a United States trademark by Carbide & Carbon Chemicals Corporation (a division of Union Carbide Corporation) for "Solvents for Gums, Resins, Cellulose Esters, and the Like". "Ethyl Cellosolve" or simply "Cellosolve" consists mainly of ethylene glycol monoethyl ether and was introduced as a lower-cost solvent alternative to ethyl lactate. "Butyl Cellosolve" ( ethylene glycol monobutyl ether) was introduced in 1928, and "Methyl Cellosolve" ( ethylene glycol monomethyl ether) in 1929.Types
Glycol ethers are designated "E-series" or "P-series" for those made from ethylene oxide or propylene oxide, respectively. Typically, E-series glycol ethers are found in pharmaceuticals, sunscreens, cosmetics, inks, dyes and water-based paints, while P-series glycol ethers are used in degreasers, cleaners, aerosol paints and adhesives. Both E- and P-series glycol ethers can be used as intermediates that undergo further chemical reactions, producing glycol diethers and glycol ether acetates. P-series glycol ethers are marketed as having lower toxicity than the E-series.Health impacts
Most glycol ethers are water-soluble, biodegradable and only a few are considered toxic. In the early 1990s, studies found higher than expected rates of miscarriages among women who worked in semiconductor plants, which was traced back to glycol ethers used in the photoresist substances that coat semiconductors. One study suggests that occupational exposure to glycol ethers is related to low motile sperm count, a finding disputed by the chemical industry.Subclasses
Solvents
* Ethylene glycol monomethyl ether (2-methoxyethanol, CH3OCH2CH2OH) * Ethylene glycol monoethyl ether (2-ethoxyethanol, CH3CH2OCH2CH2OH) * Ethylene glycol monopropyl ether (2-propoxyethanol, CH3CH2CH2OCH2CH2OH) * Ethylene glycol monoisopropyl ether (2-isopropoxyethanol, (CH3)2CHOCH2CH2OH) * Ethylene glycol monobutyl ether (2-butoxyethanol, CH3CH2CH2CH2OCH2CH2OH), a widely used solvent in paintings and surface coatings, cleaning products and inks * Ethylene glycol monophenyl ether (2-phenoxyethanol, C6H5OCH2CH2OH) * Ethylene glycol monobenzyl ether (2-benzyloxyethanol, C6H5CH2OCH2CH2OH) * Propylene glycol methyl ether, (1-methoxy-2-propanol, CH3OCH2CH(OH)CH3) * Diethylene glycol monomethyl ether (2-(2-methoxyethoxy)ethanol, methyl carbitol, CH3OCH2CH2OCH2CH2OH) * Diethylene glycol monoethyl ether (2-(2-ethoxyethoxy)ethanol, carbitol cellosolve, CH3CH2OCH2CH2OCH2CH2OH) * Diethylene glycol mono-n-butyl ether (2-(2-butoxyethoxy)ethanol, butyl carbitol, CH3CH2CH2CH2OCH2CH2OCH2CH2OH) * Dipropyleneglycol methyl ether *Dialkyl ethers
* Ethylene glycol dimethyl ether (dimethoxyethane, monoglyme, CH3OCH2CH2OCH3), a higher boiling alternative toEsters
* Ethylene glycol methyl ether acetate (2-methoxyethyl acetate, CH3OCH2CH2OCOCH3) * Ethylene glycol monoethyl ether acetate (2-ethoxyethyl acetate, CH3CH2OCH2CH2OCOCH3) * Ethylene glycol monobutyl ether acetate (2-butoxyethyl acetate, CH3CH2CH2CH2OCH2CH2OCOCH3) * Propylene glycol methyl ether acetate (1-methoxy-2-propanol acetate)References
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