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Gilles Dreyfus (born 24 May 1951) is a French cardiac surgeon.


Education

Gilles Dreyfus graduated from the Medical Faculty of Paris (Paris V, CHU Broussais – Hotel Dieu). From 1978 to 1983 he was Resident in cardiac surgery at the
Hôpitaux de Paris Greater Paris University Hospitals ( , AP-HP) is the university hospital trust operating in Paris and its surroundings. It is the largest hospital system in Europe and one of the largest in the world. It employs more than 90,000 people in 38 tea ...
, where he was trained in adult and congenital cardiac surgery guided by Professors Binet, Dubost, Guilmet and Neveux. From October 1983 to 1987, he was the Chef de Clinique for Professor
Alain Carpentier Alain Frédéric Carpentier (born 11 August 1933) is a French cardiac surgeon whom the President of the American Association for Thoracic Surgery calls the "father of modern mitral valve repair". He is most well-known for the development and po ...
, senior resident and staff surgeon at the Broussais Hospital. From 1987 to 1989, he was Consultant surgeon of the Hôpitaux de Paris, working with Professor Carpentier. In 1983, he trained for 6 months at the University of Stanford to specialize in heart and lung transplantation with Professor N.Shumway. Back in Paris, he started a transplant program at the Broussais Hospital, in the department headed by Professor Carpentier. In 1989 he became Professor of Cardio-vascular Surgery.


Career


Broussais Hospital, 1983-1989

Gilles Dreyfus started as senior resident/assistant surgeon, before becoming staff surgeon of Professor Carpentier. He acquired a specific training in
mitral valve repair Mitral valve repair is a cardiac surgery procedure performed by cardiac surgeons to treat stenosis (narrowing) or regurgitation (leakage) of the mitral valve. The mitral valve is the "inflow valve" for the left side of the heart. Blood flows f ...
and developed new surgical techniques in valve repair with Professor Carpentier, in particular he performed the first mitral valve repair in case of acute
endocarditis Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves the heart valves. Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, o ...
and he published an article on innovative surgical procedures. He also improved the transplant program at the Broussais Hospital, started by Professor Dubost and discontinued after 4 patients. The program developed rapidly: from 1984 to 1989, more than 200
heart transplant A heart transplant, or a cardiac transplant, is a surgical transplant procedure performed on patients with end-stage heart failure when other medical or surgical treatments have failed. , the most common procedure is to take a functioning heart ...
s were performed at the Broussais Hospital. An
artificial heart An artificial heart is a artificial organ, device that replaces the human heart, heart. Artificial hearts are typically used as a bridge to heart transplantation, but ongoing research aims to develop a device that could permanently replace the ...
project as a bridge to transplant was also developed. In 1986, he helped Professor Carpentier perform the first artificial heart implant in
Europe Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere. It is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, the Mediterranean Sea to the south, and Asia to the east ...
. During his stay at the Broussais Hospital, Gilles Dreyfus published several articles on heart transplant, such as ''Total orthotopic heart transplant: an alternative to the standard technique'' (Annals of Thoracic Surgery 1991), where he described a new technique called ''total heart transplant''. He was nominated Professor of Cardiovascular Surgery in 1989 by Professor Alain Carpentier.


Foch Hospital, 1989-2001

In November 1989, Gilles Dreyfus became staff surgeon of Professor Daniel Guilmet at the
Foch Hospital Foch Hospital ( French: ''Hôpital Foch'') is a teaching hospital in the Suresnes, France. It is part of the ''Établissement de santé privé d'intérêt collectif''. It was established in 1929 with the help of Consuelo Vanderbilt and Winnare ...
and Professor of Cardiovascular surgery. He performed more than 500 mitral valve repairs and described new repair techniques such as the ''
papillary muscle The papillary muscles are muscles located in the ventricles of the heart. They attach to the cusps of the atrioventricular valves (also known as the mitral and tricuspid valves) via the chordae tendineae and contract to prevent inversion or ...
repositioning'' for anterior leaflet and posterior commissural prolapse. He also improved the heart transplant program, from 10 to 25 cases per year, so that the Foch Hospital became the 2nd-3rd most active center in the region of
ÃŽle-de-France The ÃŽle-de-France (; ; ) is the most populous of the eighteen regions of France, with an official estimated population of 12,271,794 residents on 1 January 2023. Centered on the capital Paris, it is located in the north-central part of the cou ...
. Gilles Dreyfus continued the research on artificial hearts as a bridge to transplant, implanting TCI and NOVACOR for the first time in France. In 1998, after Professor Guilmet’s retirement, Gilles Dreyfus became chief of cardiac and vascular surgery of the Foch Hospital, continuing the surgical activity and developing the heart valve repair surgery, the ventricular assist devices and heart transplant programs. In 2000, French actor
Gérard Depardieu Gérard Xavier Marcel Depardieu (, , ; born 27 December 1948) is a French actor. An icon of French cinema, considered a world star in the same way as Alain Delon or Brigitte Bardot, he has completed over 250 films since 1967, most of which as ...
underwent
coronary artery bypass surgery Coronary artery bypass surgery, also known as coronary artery bypass graft (CABG, pronounced "cabbage"), is a surgical procedure to treat coronary artery disease (CAD), the buildup of plaques in the arteries of the heart. It can relieve chest ...
performed by Professor Dreyfus.


London : Royal Brompton and Harefield, NHS Trust, 2001-2009

In April 2001, Gilles Dreyfus joined Professor Sir
Magdi Yacoub Sir Magdi Habib Yacoub ( ; born 16 November 1935) is an Egyptian-British retired professor of cardiothoracic surgery at Imperial College London, best known for his early work in repairing heart valves with surgeon Donald Ross, adapting the ...
at the
Harefield Hospital Harefield Hospital is a health institution in Harefield, London Borough of Hillingdon, England. It is managed by the Guy's and St Thomas' NHS Foundation Trust. History The first hospital on the site was the No. 1 Australian Auxiliary Hospital es ...
in
London London is the Capital city, capital and List of urban areas in the United Kingdom, largest city of both England and the United Kingdom, with a population of in . London metropolitan area, Its wider metropolitan area is the largest in Wester ...
, UK. They worked together for 6 months before Professor Dreyfus became director of the cardio-thoracic surgery in October 2001, following Sir Yacoub’s retirement. He was nominated Professor of cardio-thoracic surgery at the
Imperial College School of Medicine Imperial College School of Medicine (ICSM) is the undergraduate medical school of Imperial College London in England and one of the United Hospitals. It is part of the college's Imperial College Faculty of Medicine, Faculty of Medicine and was ...
(2nd University of UK) and then became director of the cardio-thoracic surgery and transplantation at the Harefield Hospital. He also continued his research on mitral valve surgery and on
tricuspid valve The tricuspid valve, or right atrioventricular valve, is on the right dorsal side of the mammalian heart, at the superior portion of the right ventricle. The function of the valve is to allow blood to flow from the right atrium to the right vent ...
. In 2003, he presented a research paper at the
AATS Tech College Aalborg is a school in the city of Aalborg, in North Jutland in Denmark. It offers a wide spectrum of vocational training and runs Aalborg Tekniske Gymnasium. The school has about 4500 yearly students and 650 employees. Department ...
annual meeting with a study population of 311 patients, divided in two subgroups: one underwent isolated mitral valve repair, the other mitral valve repair associated to tricuspid valve repair. In this research, professor Dreyfus demonstrated the rationale in treating the tricuspid annulus dilation independently from the presence of
tricuspid regurgitation Tricuspid regurgitation (TR), also called tricuspid insufficiency, is a type of valvular heart disease in which the tricuspid valve of the heart, located between the right atrium and right ventricle, does not close completely when the right ventr ...
. This principle influenced the guidelines of the international societies of Cardiology, may it be the
American College of Cardiology The American College of Cardiology (ACC), based in Washington, D.C., is a nonprofit medical association established in 1949. It bestows credentials upon cardiovascular specialists who meet its qualifications. Education is a core component of the ...
/
American Heart Association The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate Heart, cardiac care in an effort to reduce disability ...
, or the
European Society of Cardiology The European Society of Cardiology (ESC) is an independent Nonprofit organisation, non-profit, non-governmental professional association that works to advance the prevention, diagnosis and management of diseases of the heart and blood vessels, a ...
. He also focused his research on a new technique to replace the
aortic valve The aortic valve is a valve in the heart of humans and most other animals, located between the left ventricle and the aorta. It is one of the four valves of the heart and one of the two semilunar valves, the other being the pulmonary valve. ...
, using autologous
pericardium The pericardium (: pericardia), also called pericardial sac, is a double-walled sac containing the heart and the roots of the great vessels. It has two layers, an outer layer made of strong inelastic connective tissue (fibrous pericardium), ...
. Results of this method, called ''Cardiomend'' were presented at the American Society of Thoracic Surgeons annual meeting in 2001 and were the object of two articles. As Director of one of the largest centers for transplantation in Europe, he led a program of heart and
lung transplant Lung transplantation, or pulmonary transplantation, is a surgical procedure in which one or both lungs are replaced by lungs from a donor. Donor lungs can be retrieved from a living or deceased donor. A living donor can only donate one Lobes of t ...
and cardiac assist devices. Under his influence, the Harefield group was the first group in Europe to implant the Jarvik 2000, in addition to other assist devices as destination therapy or as bridge-to-recovery in case of heart failure. While practicing in London, he operated the Queen of Spain's brother, the Queen of England's cousin, the King Constantin of Greece. In 2002, professor Dreyfus, along with three other famous European surgeons specialized in mitral valve repair, developed the ''Master of Valve Repair'', a training course supported by
Edwards Lifesciences Edwards Lifesciences is an American medical technology company headquartered in Irvine, California, specializing in artificial heart valves and hemodynamic monitoring. It developed the Sapien transcatheter aortic heart valve made of cow tissue w ...
, happening twice or thrice a year, where more than 2000 European surgeons have been trained to advanced techniques in mitral valve repair.


Cardio-Thoracic Centre in Monaco

In January 2010, upon the request of Professor Vincent Dor, Gilles Dreyfus was appointed as Medical Director or the Cardio-Thoracic Centre in Monaco, taking over Professor Dor who retired.Le professeur Gilles Dreyfus au CCM de Monaco
''Nouvel Obs'', 7 janvier 2010


Awards and honours

* Knight of the Legion d’Honneur (2001)


References


Further reading

* http://news.bbc.co.uk/2/hi/health/3330251.stm


External links


Official website
{{DEFAULTSORT:Dreyfus, Gilles Living people French surgeons Academic staff of the University of Paris 1951 births Recipients of the Legion of Honour