Personality traits are patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Personality is influenced by genetic and environmental factors and associated with

mental health Mental health encompasses emotional, psychological, and social well-being, influencing cognition, perception, and behavior. It likewise determines how an individual handles stress, interpersonal relationships, and decision-making. Mental hea ...

. Beside the environment factor, genetic variants can be detected for personality traits. These traits are mainly

polygenic A polygene is a member of a group of non- epistatic genes that interact additively to influence a phenotypic trait, thus contributing to multiple-gene inheritance (polygenic inheritance, multigenic inheritance, quantitative inheritance), a type o ...

. Significant genetic variants are present for most of the behavioral traits. There is a consistency in detection of genetic variants and genomic association for traits derived from

pedigree Pedigree may refer to: Breeding * Pedigree chart, a document to record ancestry, used by genealogists in study of human family lines, and in selective breeding of other animals ** Pedigree, a human genealogy (ancestry chart) ** Pedigree (animal ...

Trait theory

The

Big Five personality traits The Big Five personality traits is a suggested taxonomy, or grouping, for personality traits, developed from the 1980s onward in psychological trait theory. Starting in the 1990s, the theory identified five factors by labels, for the US Englis ...

, also known as the five-factor model (FFM) and the OCEAN model, is a taxonomy for

personality Personality is the characteristic sets of behaviors, cognitions, and emotional patterns that are formed from biological and environmental factors, and which change over time. While there is no generally agreed-upon definition of personality, mos ...

traits. When

factor analysis Factor analysis is a statistical method used to describe variability among observed, correlated variables in terms of a potentially lower number of unobserved variables called factors. For example, it is possible that variations in six observed ...

(a statistical technique) is applied to personality survey data, some words used to describe aspects of personality are often applied to the same person. For example, someone described as conscientious is more likely to be described as "always prepared" rather than "messy". This theory is based therefore on the association between words but not on

neuropsychological Neuropsychology is a branch of psychology concerned with how a person's cognition and behavior are related to the brain and the rest of the nervous system. Professionals in this branch of psychology often focus on how injuries or illnesses of ...

experiments. This theory uses descriptors of common language and therefore suggests five broad dimensions commonly used to describe the human

and

psyche Psyche (''Psyché'' in French) is the Greek term for "soul" (ψυχή). Psyche may also refer to: Psychology * Psyche (psychology), the totality of the human mind, conscious and unconscious * ''Psyche'', an 1846 book about the unconscious by Car ...

. The five factors are: *

Openness to experience Openness to experience is one of the domains which are used to describe human personality in the Five Factor Model. Openness involves six facets, or dimensions: active imagination (fantasy), aesthetic sensitivity, attentiveness to inner feelings, ...

(''inventive/curious'' vs. ''consistent/cautious'') *

Conscientiousness Conscientiousness is the personality trait of being careful, or diligent. Conscientiousness implies a desire to do a task well, and to take obligations to others seriously. Conscientious people tend to be efficient and organized as opposed to e ...

(''efficient/organized'' vs. ''easy-going/careless'') *

Extraversion The traits of extraversion (also spelled extroversion Retrieved 2018-02-21.) and introversion are a central dimension in some human personality theories. The terms ''introversion'' and ''extraversion'' were introduced into psychology by Carl J ...

(''outgoing/energetic'' vs. ''solitary/reserved'') *

Agreeableness Agreeableness is a personality trait manifesting itself in individual behavioral characteristics that are perceived as kind, sympathetic, cooperative, warm, and considerate. In contemporary personality psychology, agreeableness is one of the five ...

(''friendly/compassionate'' vs. ''challenging/detached'') *

Neuroticism In the study of psychology, neuroticism has been considered a fundamental personality trait. For example, in the Big Five approach to personality trait theory, individuals with high scores for neuroticism are more likely than average to be moody ...

(''sensitive/nervous'' vs. ''secure/confident'').

Methods

The methods mostly used in

genomics Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dim ...

of personality traits' studies are two: analytic methods and not-analytic ones (such as questionnaires).

Analytic

Analytical techniques that can be used to measure genomics of personality include: # GWAS, genome wide association study is a method used to define markers (these markers are single nucleotide

polymorphism Polymorphism, polymorphic, polymorph, polymorphous, or polymorphy may refer to: Computing * Polymorphism (computer science), the ability in programming to present the same programming interface for differing underlying forms * Ad hoc polymorphis ...

, SNPs) across the genomes in order to better understand the contribution of genetics to personality traits. Since SNPs occur in the DNA between genes, GWAS technique aims to find those genes that are associated with certain personality traits, for example neuroticism was reported to be associated with

intron An intron is any nucleotide sequence within a gene that is not expressed or operative in the final RNA product. The word ''intron'' is derived from the term ''intragenic region'', i.e. a region inside a gene."The notion of the cistron .e., gene ...

ic variant in

MAGI1 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the ''MAGI1'' gene. Function The protein encoded by this gene is a member of the membrane-associated guanylate kinase homolog ...

and openness with variants near

RASA1 RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities: * Inactivation of Ras from its active GTP-bound form to its inactive GDP-bou ...

. Recently, UK Biobank achieved several SNPs that are associated with

neuroticism In the study of psychology, neuroticism has been considered a fundamental personality trait. For example, in the Big Five approach to personality trait theory, individuals with high scores for neuroticism are more likely than average to be moody ...

. The first GWAS studies on all five human personality factors (i.e. neuroticism,

extraversion The traits of extraversion (also spelled extroversion Retrieved 2018-02-21.) and introversion are a central dimension in some human personality theories. The terms ''introversion'' and ''extraversion'' were introduced into psychology by Carl J ...

, openness to experience, conscientiousness and agree- ableness) used a sample of 3972 individuals from an isolated population on Sardinia, Italy, and found 362 129 SNPs. # DNA

genotyping Genotyping is the process of determining differences in the genetic make-up (genotype) of an individual by examining the individual's DNA sequence using biological assays and comparing it to another individual's sequence or a reference sequence. ...

, which can be performed through different kits, for example: #*The CanineHD BeadChip containing 173,662 validated

SNPs In genetics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently larg ...

derived from the Dog Genome Sequencing Project. This chip has 99.99% of

reproducibility Reproducibility, also known as replicability and repeatability, is a major principle underpinning the scientific method. For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a ...

, it is a

PCR PCR or pcr may refer to: Science * Phosphocreatine, a phosphorylated creatine molecule * Principal component regression, a statistical technique Medicine * Polymerase chain reaction ** COVID-19 testing, often performed using the polymerase chain r ...

-free protocol, it provides a uniform genome-wide coverage by the 70 markers placed on the platform, it has a high-

throughput Network throughput (or just throughput, when in context) refers to the rate of message delivery over a communication channel, such as Ethernet or packet radio, in a communication network. The data that these messages contain may be delivered ov ...

(up to 12 samples in parallel) and it can be applied to the interrogation of

genetic variation Genetic variation is the difference in DNA among individuals or the differences between populations. The multiple sources of genetic variation include mutation and genetic recombination. Mutations are the ultimate sources of genetic variation, b ...

in any domestic dog breed. The full set of SNPs that it contains can be analysed with the purpose of explaining the proportion of the

phenotypic In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological proper ...

traits' variances and to show the "genomic heritabilities" of the traits (considering the total of the autosomal and X-linked estimates). For example, the study that used this approach revealed a significant genetic variance present for most of the behavioural traits examined. #* The Infinium OmniExpress-24 BeadChip array containing 710,000 SNPs. #* The data obtained from the DNA genotyping can be filtered by many software, such the Genome Studio one, which is able to analyze SNP data across 5 million markers and probes and that can detect sample outliers. Moreover, the data can be then subjected to stringent quality controls, such that of PLINK v1.9. # RNA sequencing can provide a more precise elucidation of common genetic influences on

gene expression Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. ...

in the developing brain and the molecular differences that could confer susceptibility to neuropsychiatric disorders. With this technique combined to the GWAS, it was possible, to provide the first

eQTL Expression quantitative trait loci (eQTLs) are genomic loci that explain variation in expression levels of mRNAs. Distant and local, trans- and cis-eQTLs, respectively An expression quantitative trait is an amount of an mRNA transcript or a pr ...

dataset derived exclusively from the human fetal brain. One example of protocol used to do it is the following: total RNA was treated with DNase and purified. Integrity of RNA was assessed and then RNA-Seq libraries were prepared using 1 μg of purified total RNA, depleting ribosomal RNA and modifying the RNA fragmentation times for lower RIN samples (<7). Also library size was assessed and then libraries were quantified. At the end, libraries were sequenced, generating at least 50 million read pairs (100 million reads) per sample. # Whole-Genome Bisulfite Sequencing (WGBS) to examine

DNA methylation DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts ...

in cellular subpopulations isolated from human brain tissue. This analysis is important, because DNA methylation differences between neuronal and non-neuronal populations have been widely reported and many neuropsychiatric diseases preferentially affect neuronal subpopulations present in particular brain regions. An example of WGBS protocol is the following: samples were fragmented and then they were bisulfite converted after size selection. Amplification was performed after the

bisulfite The bisulfite ion (IUPAC-recommended nomenclature: hydrogensulfite) is the ion . Salts containing the ion are also known as "sulfite lyes". Sodium bisulfite is used interchangeably with sodium metabisulfite (Na2S2O5). Sodium metabisulfite diss ...

conversion using Kapa Hifi Uracil + polymerase at the following cycling conditions: 98 °C 45 s/8 cycles: 98 °C 15 s, 65 °C 30 s, 72 °C 30 s/72 °C 1 min. Final libraries were run for quality control purposes. Then, libraries were quantified by qPCR. Libraries were also sequenced using a 125 bp paired-end single indexed run. #

Karyotyping A karyotype is the general appearance of the complete set of metaphase chromosomes in the cells of a species or in an individual organism, mainly including their sizes, numbers, and shapes. Karyotyping is the process by which a karyotype is disce ...

is performed to determine fetal sex. Sex is a parameter considered as a covariate in some studies of characterization of personality traits. # Candidate gene approach focus on genes whose function suggests an association with a trait. Originally, it was assumed that few key genes were responsible for the observed heritable variance of personality features. Even though the complexity behind the polygenicity of personality traits was demonstrated, candidate gene studies are still performed today. The small number of genes selected for this type of studies are included in

neurotransmission Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), ...

patterns, like the ones involving

dopamine Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. Dopamine constitutes about 8 ...

and serotonin. The most studied candidate genes and polymorphism related to personality, with the most informative

meta-analyses A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting me ...

, are ''DRD4'' and ''5HTT''. ''DRD4'' encodes for the D4 dopamine receptor, while ''5HTT'' encodes for a

serotonin transporter The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein th ...

responsible for the

reuptake Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of trans ...

of this neurotransmitter. According to some publications, SNPs in DRD4 are associated with extraversion and novelty seeking. Also variations in ''5HTT'' are associated with neuroticism and harm avoidance. # Family and twins studies: The studies of

of personality traits involves families and specifically twins, because they have a high heritability of the traits. The families and twins studies have showed that personality traits are moderately heritable, and can predict various lifetime outcomes, including

psychopathology Psychopathology is the study of abnormal cognition, behaviour, and experiences which differs according to social norms and rests upon a number of constructs that are deemed to be the social norm at any particular era. Biological psychopathol ...

. The identical twins have a heritability of 40%, suggesting that the

additive genetic effects Additive genetic effects occur when two or more genes source a single contribution to the final phenotype, or when alleles of a single gene (in heterozygotes) combine so that their combined effects equal the sum of their individual effects. Non ...

are responsible for the variance of personality traits for a moderate portion. Family and adoption studies have yielded of approximately 30%. The sex is not involved in heritability of personality traits, on the other end environmental differences can increase or decrease the importance of genetic factors. Twins data shows that genetic influences contribute to personality stability and are relatively constant with age whereas environmental influence on personality increases with age. In addition, twin and family studies show strong genetic correlations across diverse cognitive domains, suggesting

pleiotropy Pleiotropy (from Greek , 'more', and , 'way') occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene. Mutation in a pleiotropic ge ...

, and across levels of ability, substantiating the view of general intelligence as an etiological continuum. The families have members affected by

psychiatric disorder A mental disorder, also referred to as a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. Such features may be persistent, relapsing and remitti ...

, because these diseases can be considered as extremes of normal tendencies and personal traits. It is intended to foster a biological analysis of behavior in order to study

neurological disorder A neurological disorder is any disorder of the nervous system. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms. Examples of symptoms include paralysis, muscle weakn ...

and find a correlation with human personality, meaning that heritable variation in personality traits would share a common genetic basis with psychiatric diseases. The geneticists define the phenotype of the patients following the

Human Phenotype Ontology The Human Phenotype Ontology (HPO) is a formal ontology of human phenotypes. Developed in collaboration with members of the Open Biomedical Ontologies Foundry, HPO currently contains over 13,000 terms and over 156,000 annotations to hereditary dise ...

(HPO) which provides a standardized vocabulary of phenotypic abnormalities encountered in human disease. The study of complex trait in genetics presents a gap defined as "missing heritability", so a single genetic variations cannot account for much of the heritability of diseases, behaviors, and other

phenotype In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological prop ...

s. For example, a person susceptibility to disease may depend more on the combined effect of all the genes in the background than on the disease genes in the foreground, or the role of genes may have been severely overestimated.

Non analytic

Non-analytic methods mainly use approach is that of questionnaire, here discuss: Questionnaires: As previously mentioned,

questionnaire A questionnaire is a research instrument that consists of a set of questions (or other types of prompts) for the purpose of gathering information from respondents through survey or statistical study. A research questionnaire is typically a mix of ...

s were often used as another tool to analyze the association of a behaviour to genetic variances. In some studies, questionnaires were indirectly given at the owners of the animals involved in the experiment and in other studies they were directly given to the patients involved. These questionnaires were: # C-BARQ, which stands for Canine Behavioural Assessment and Research Questionnaire. It is a survey-based approach used in a large number of studies on dog behaviour, where the dog owner's answers to validated questionnaires to assess the personality traits of the dog. C-BARQ was developed at the

University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universit ...

and its reliability, validity and standardized test scores support its use as a tool in behavioural researches. The C-BARQ survey contains 101 questions regarding the dog's behavioural response to various situations, with answers marked on a five-step scale. Depending on the results obtained from the compilation of the survey the dogs are divided into 11-14 behavioural traits' groups. # Demographic questionnaires about general information of the dogs, such as sex, neuter status, housing, coat colour, health status, exercise per day and "Role" (based on the activities of the dog). The data obtained from questionnaires can be analysed by the Mixed Linear Model (REML) approach, that provides a consistent and accurate estimation of non-normally-distributed traits. This approach can be implemented using software as ASReml. # Self-report questionnaires, which investigate several aspects of participants' life. Some examples are the following: #*The Eysenck Personality Questionnaire (EPQ), defines 3 traits of personality:

psychoticism Psychoticism is one of the three traits used by the psychologist Hans Eysenck in his P–E–N model ( psychoticism, extraversion and neuroticism) model of personality. Nature Psychoticism is conceptually similar to the ''constraint'' factor in ...

(characterized by aggressiveness and interpersonal hostility),

(manifested in outgoing, energetic behaviour) and

(typified by emotional stability). #*The Tridimensional Personality Questionnaire (TPQ) defines 3 traits of personality that are based on the biochemical bases of temperament:

novelty seeking In Cloninger's model of psychobiology, novelty seeking (NS) is an inherited, unlearned, temperamental bias toward novel signals from the environment. It can be measured along a spectrum from low to high (as with 3 other temperamental domains) and ...

harm avoidance Harm avoidance (HA) is a personality trait characterized by excessive worrying; pessimism; shyness; and being fearful, doubtful, and easily fatigued. In MRI studies HA was correlated with reduced grey matter volume in the orbito-frontal, occipit ...

and

reward dependence Reward dependence is characterized as a tendency to respond markedly to signals of reward, particularly to verbal signals of social approval, social support, and sentiment. When reward dependence levels deviate from normal we see the rise of several ...

. #*The Temperament and Character Inventory (TCI) defines 4 personality: persistence (or perseverance despite fatigue or frustration),

self-directedness Self-directedness is a personality trait of self-determination, that is, the ability to regulate and adapt behavior to the demands of a situation in order to achieve personally chosen goals and values. It is one of the "character" dimensions in Clon ...

(the ability to modify behaviour in order to achieve personal goals),

cooperativeness Cooperativeness is a personality trait concerning the degree to which a person is generally agreeable in their relations with other people as opposed to aggressively self-centred and hostile. It is one of the "character" dimensions in Cloninger's T ...

(the tendency to exhibit agreeable relations with others) and

self-transcendence Self-transcendence is a personality trait that involves the expansion of personal boundaries, including, potentially, experiencing spiritual ideas such as considering oneself an integral part of the universe. Several psychologists, including Viktor ...

(associated with experiencing spiritual aspects of the self). #*The Five Factor model (NEO-PI) is based on biological mechanisms shaping 5 higher-order traits (the big five):

(proneness to experience negative affect),

(motivation to engage with others),

openness to experience Openness to experience is one of the domains which are used to describe human personality in the Five Factor Model. Openness involves six facets, or dimensions: active imagination (fantasy), aesthetic sensitivity, attentiveness to inner feelings, ...

(inventive or curious behaviour),

agreeableness Agreeableness is a personality trait manifesting itself in individual behavioral characteristics that are perceived as kind, sympathetic, cooperative, warm, and considerate. In contemporary personality psychology, agreeableness is one of the five ...

(friendliness and compassion toward others) and

conscientiousness Conscientiousness is the personality trait of being careful, or diligent. Conscientiousness implies a desire to do a task well, and to take obligations to others seriously. Conscientious people tend to be efficient and organized as opposed to e ...

(attentive and organized behaviour). This questionnaire is the most commonly used for genetic studies and it has also derivative types, such as the NEO-PI-R and NEO-FFI. #*UK Biobank self-report questionnaire has several questions related to

loneliness Loneliness is an unpleasant emotional response to perceived isolation. Loneliness is also described as social paina psychological mechanism which motivates individuals to seek social connections. It is often associated with a perceived lack ...

and social isolation and it permit to identify cases and controls and then also to compare genetic differences. Some examples of questions are: 'Do you often feel lonely?', to which individuals answered 'yes' (recorded as cases) or 'no' (controls); other questions are based on the quality of social interactions as: 'How often are you able to confide in someone close to you?' (cases were defined as those who answered 'Never or almost never', controls were defined as those who answered 'Almost daily').

Correlation with psychiatric disorder

Scientists demonstrated that most of personality traits cluster together and they also cluster with most

neuropsychiatric disorders A mental disorder, also referred to as a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. Such features may be persistent, relapsing and remitti ...

and are therefore related. In research, scientists used linkage disequilibrium regression score to investigate the correlation between personality traits and psychiatric disorder. According to LDSC, there is a positive correlation between

major depression disorder Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introdu ...

and neuroticism and a small correlation between schizophrenia and

; these correlation have also been confirmed in twins studies. Also, neuroticism and openness show strong genetic correlation. Besides, scientists found that there is a positive correlation between first principle component and all psychiatric disorders but first principle component showed negative correlation with conscientiousness and agreeableness. Personality features are highly linked with mental, social and physical outcome. For example, scientists realized that schizophrenia and bipolar disorders cluster with openness. Moreover, they demonstrated that ADHD shows the highest correlation with personality trait especially

. Recently, the negative correlation between neuroticism and loneliness was identified as well as a strong correlation between anxiety and neuroticism. Plus,

narcissism Narcissism is a self-centered personality style characterized as having an excessive interest in one's physical appearance or image and an excessive preoccupation with one's own needs, often at the expense of others. Narcissism exists on a co ...

, psychopathy and

Machiavellianism Machiavellianism or Machiavellian may refer to: Politics * Machiavellianism (politics), the supposed political philosophy of Niccolò Machiavelli *Political realism Psychology *Machiavellianism (psychology), a personality trait centered on cold a ...

have association with low agreeableness. In general, neuroticism and other personality traits show negative correlation, while openness, extraversion, agreeableness and conscientiousness shows positive correlation. Example for the genes that they find to be correlative are: Within 8p23.1, MTMR9 has

ic variant which has association with extraversion and also with neuroticism shows inverse association. Another one is 12q23.3, WSCD2 which is found for extraversion, by using GWAS, it had been shown that this locus has association with

bipolar disorder Bipolar disorder, previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood that last from days to weeks each. If the elevated mood is severe or associated with ...

. In addition, L3MBTL2 is associated with both

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social wi ...

and

. Another gene is DRD4 which has association with both ADHD and novelty seeking behavior.

Examples

# Genetic basis of Dog Personality Traits: in different genomes of dogs, several SNPs are found close to genes with known neurological or behavioral functions. The TH (tyrosin hydroxylase) gene, whose product is LDOPA, the precursor of the neurotransmitter dopamine, is located 1 Mb from the SNP on CFA18 associated with agitated behaviour. Mutation in this gene cause

hyperactivity disorder Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by excessive amounts of inattention, hyperactivity, and impulsivity that are pervasive, impairing in multiple contexts, and otherwise age-inappr ...

. The TH gene has been associated with activity, impassivity, and inattention in two dog breeds. The SNP associated with NoiseFear is located 0.27 Mb from

CADPS2 Calcium-dependent secretion activator 2 is a protein that in humans is encoded by the ''CADPS2'' gene. Function This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium-binding protei ...

on CFA20. CADPS2 is a member of a gene family encoding calcium-binding proteins that regulate the

exocytosis Exocytosis () is a form of active transport and bulk transport in which a cell transports molecules (e.g., neurotransmitters and proteins) out of the cell ('' exo-'' + '' cytosis''). As an active transport mechanism, exocytosis requires the use ...

of neuropeptide encompassing (dense-core) vesicles from neurons and neuron endocrine cells. The gene and its variants have been associated with

autism The autism spectrum, often referred to as just autism or in the context of a professional diagnosis autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental condition (or conditions) characterized by difficulti ...

in humans and noise phobia reported for dogs with this SNPs. Similar SNPs in dogs and in humans are correlated with the same gene which has different outcomes in terms of personality traits. # Intelligence is one of the traits that are affected by genetics. Inherited DNA differences are responsible for substantial individual differences in intelligence test scores the 10% variance in intelligence scores explained by the SNP heritability. # From twins studies it is possible to consider neuroticism as a heritable trait, as shown in a meta-analysis of data from over 29 000 twin pairs, in which they found this correlation in 16 twin pairs, independently from the sex of individuals.

Limitations

* GWAS studies require very large sample size in order to be able to identify the polymorphisms which are responsible for the variance observed, since personality traits are influenced by many genes, each one explaining only a small amount of variations (1 – 2%). * Whole genome bisulfite sequence method has some limitations, because it is an exclusively qualitative method, so, it is possible to analyze the methylation status of only a limited number of CpG dinucleotides. * Candidate gene association studies led to inconsistent and inconclusive results due to the fact that the effect of the loci under study was considered to be much larger than it really was, wrong assumptions were made regarding the importance of genes related to key neurotransmitter systems, regulatory and noncoding regions were not taken into consideration. * Family and twins studies may result in the confounding of pedigree genetic effects with shared family environmental effects. Moreover, shared environment effects could obscure dominance variation causing dizygotic twins to appear more alike than monozygotic twins.

References

{{Reflist

External links

Human Phenotype Ontology
Genomics