Febrifugine is a

quinazolinone Quinazolinone is a heterocyclic chemical compound, a quinazoline with a carbonyl group in the C4N2 ring. Two isomers are possible: 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. These compounds are of interest in ...

alkaloid Alkaloids are a broad class of natural product, naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids. Alkaloids are produced by a large varie ...

first isolated from the Chinese herb '' Dichroa febrifuga'', but also found in the garden plant ''

Hydrangea ''Hydrangea'' ( or ) is a genus of more than 70 species of Flowering plant, flowering plants native plant, native to Asia and the Americas. Hydrangea is also used as the common name for the genus; some (particularly ''Hydrangea macrophylla, H. m ...

''. Laboratory synthesis of febrifugine determined that the originally reported stereochemistry was incorrect. Febrifugine has

antimalarial Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young ...

properties and the synthetic

halogen The halogens () are a group in the periodic table consisting of six chemically related elements: fluorine (F), chlorine (Cl), bromine (Br), iodine (I), and the radioactive elements astatine (At) and tennessine (Ts), though some authors would ...

ated

derivative In mathematics, the derivative is a fundamental tool that quantifies the sensitivity to change of a function's output with respect to its input. The derivative of a function of a single variable at a chosen input value, when it exists, is t ...

halofuginone Halofuginone, sold under the brand name Halocur, is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb '' Dichroa febrifu ...

is used in veterinary medicine as a

coccidiostat A coccidiostat is an antiprotozoal agent that acts upon Coccidia parasites. Examples include: * Amprolium * Arprinocid * Artemether * Clazuril * Clopidol * Decoquinate * Diclazuril * Dinitolmide * Ethopabate * Halofuginone * Lasalocid * ...

. Other synthetic febrifugine derivatives have been used against malaria, cancer, fibrosis, and inflammatory disease.

References

{{reflist Quinazolinones Piperidine alkaloids