FYVE, RhoGEF and PH domain-containing protein 3 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''FGD3''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
See also
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FYVE, RhoGEF and PH domain containing FYVE, RhoGEF and PH domain containing (FGD) is a gene family consisting of:
* FGD1
* FGD2
* FGD3
* FGD4
Type 1 is associated with Aarskog-Scott syndrome.
See also
* Guanine nucleotide exchange factor
Guanine nucleotide exchange factors ( ...
**
FYVE domain
In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind phosphatidyli ...
(zinc finger domain)
**
RhoGEF domain
RhoGEF domain describes two distinct structural domains with guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family. Rho small GTPases are inactive when bound to GDP but active when bound to GTP; RhoGEF ...
(with
guanine nucleotide exchange factor
Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structu ...
activity)
**
PH domain
Pleckstrin homology domain (PH domain) or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
This domain can bind phosph ...
(pleckstrin homology domain)
References
Further reading
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External links
PDBe-KBprovides an overview of all the structure information available in the PDB for Human FYVE, RhoGEF and PH domain-containing protein 3 (FGD3)
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