Evelyn Nicol
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Evelyn Marie Carmon Nicol (June 2, 1930 – May 27, 2020) was an American immunologist and
microbiologist A microbiologist (from Greek ) is a scientist who studies microscopic life forms and processes. This includes study of the growth, interactions and characteristics of microscopic organisms such as bacteria, algae, fungi, and some types of par ...
. She was the first scientist to isolate the
herpes zoster virus Varicella zoster virus (VZV), also known as human herpesvirus 3 (HHV-3, HHV3), is one of nine known herpes viruses that can infect humans. It causes chickenpox (varicella) commonly affecting children and young adults, and shingles (herpes zos ...
, and is one of the few
African American African Americans, also known as Black Americans and formerly also called Afro-Americans, are an Race and ethnicity in the United States, American racial and ethnic group that consists of Americans who have total or partial ancestry from an ...
women to receive a patent in
molecular biology Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...
, for a new production method of
urokinase Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein was discovered, but not named, by McFarlane and Pilling in 1947. Urokinase was originally ...
.


Early life and education

Nicol was born in Little Rock, Kentucky. Her parents were Daniel Eugene Carmon, a schoolteacher, and Margarite Wilson Carmon, a homemaker. She was 8th of 11 children. In an interview for Lifeology, Nicol explained that despite her family having very little: "we used to have a lot of fun. You couldn't grow up any better than that." As their local school was underfunded, and only went up to the eighth grade, Nicol's father took it upon himself to give the children extra homeschooling. During her high school years, Nicol worked as a domestic to earn money. When she graduated from high school, Nicol was offered a scholarship at
Tuskegee University Tuskegee University (Tuskegee or TU; formerly known as the Tuskegee Institute) is a private, historically black land-grant university in Tuskegee, Alabama, United States. It was founded as a normal school for teachers on July 4, 1881, by the ...
to study Home Economics. She moved to Alabama in 1949 to attend university, but she chose to study Mathematics and Chemistry instead of Home Economics. She funded her studies by working two jobs. Nicol graduated at the top of her class in 1953 with a degree in Chemistry and Mathematics, and earned the
Beta Kappa Chi Beta Kappa Chi () is an American collegiate honor society that recognizes academic achievement in the fields of natural science and mathematics. It was established in 1923 at Lincoln University, an historically Black university near Oxford, Penns ...
and
Alpha Kappa Mu The Alpha Kappa Mu National Honor Society () is an American collegiate honor society recognizing academic excellence in all areas of study. History Alpha Kappa Mu was founded on at Tennessee Agricultural & Industrial State College in Nashville ...
honors.


Research and career

From 1953 to 1955, Nicol worked as a research assistant for the Salk Polio Project of the Carver Research Foundation. Under the supervision of Dr. Russel W. Brown, she worked on developing the first polio vaccine using
HeLa HeLa () is an immortalized cell line used in scientific research. It is the oldest human cell line and one of the most commonly used. HeLa cells are durable and prolific, allowing for extensive applications in scientific study. The line is ...
cell cultures. Nicol then joined the Cleveland City Hospital, working with Frederick C. Robbins and John F. Enders. There, she was the first person to successfully isolate the herpes zoster virus, which causes
shingles Shingles, also known as herpes zoster or zona, is a viral disease characterized by a painful skin rash with blisters in a localized area. Typically the rash occurs in a single, wide mark either on the left or right side of the body or face. T ...
, using amniotic cells in tissue culture. In an interview for Lifeology, Nicol said: "Things just come to me. I don't know why. It just seems like common sense." Following these her early career successes, Nicol was recruited by Rand Development Corporation, where she worked on isolating the
leukemia Leukemia ( also spelled leukaemia; pronounced ) is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or '' ...
agent. During this time, Nicol also worked for the University of Kansas Medical Centre, and the
Michael Reese Hospital Michael Reese Hospital and Medical Center was an American hospital located in the Bronzeville neighborhood of Chicago, Illinois. Founded in 1881, Michael Reese Hospital was a major research and teaching hospital and one of the oldest and largest ...
. Nicol then joined
Abbott Laboratories Abbott Laboratories is an American multinational medical devices and health care company with headquarters in Abbott Park, Illinois, in the United States. The company was founded by Chicago physician Wallace Calvin Abbott in 1888 to formulate k ...
as a research assistant in 1962. There, she faced discrimination from her white colleagues, who would take credit for results and sabotage her work. On 6 January 1976, Nicol patented a new technique to increase the production yield of urokinase (U.S. Patent No. 3,930,944), an enzyme used to dissolve blood clots. She was one of the few African American women to be awarded a patent in molecular biology at that time. Among her many achievements while working at Abbott, Nicol successfully developed a test for
toxoplasmosis Toxoplasmosis is a parasitic disease caused by ''Toxoplasma gondii'', an apicomplexan. Infections with toxoplasmosis are associated with a variety of neuropsychiatric and behavioral conditions. Occasionally, people may have a few weeks or month ...
in pregnant women, and an
interferon Interferons (IFNs, ) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten ...
assay. In 1985, Nicol was recruited by
Baxter Pharmaceuticals Baxter International Inc. is an American multinational healthcare company with headquarters in Deerfield, Illinois. The company primarily focuses on products to treat chronic and acute medical conditions. The company had 2023 global net sa ...
. Within their hepatitis research and development group, known as Pandex, Nicol led the
retrovirology A retrovirus is a type of virus that inserts a DNA copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell. After invading a host cell's cytoplasm, the virus uses its own reverse transcriptase e ...
division, which produced testing kits for blood-borne diseases such as
HIV The human immunodeficiency viruses (HIV) are two species of '' Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the im ...
and human T-cell lymphotropic virus. Two blind studies funded by Abbott Pharmaceuticals determined that the testing kits produced under Nicol's leadership were the best available. While at Baxter pharmaceuticals, Nicol used her seniority to combat workplace discrimination, and advocate for fairer hiring practices. For example, she hired Linda Smith, whose resume had initially been rejected, likely because she had studied at a
historically Black university Historically Black colleges and universities (HBCUs) are institutions of higher education in the United States that were established before the Civil Rights Act of 1964 with the intention of serving African Americans. Most are in the Southern U ...
. While she was working there, Pandex was bought by Nicol's former employer Abbott Laboratories. Nicol retired in 1990, refusing to work for a company that had been so openly discriminatory.


Personal life

Nicol had three children. Upon retirement, she lived in
Waukegan, Illinois Waukegan ( ) is a city in Lake County, Illinois, United States, and its county seat. Located north of Chicago, Waukegan is a satellite city within the greater Chicago metropolitan area. As of the 2020 census, its population was 89,321, makin ...
, and later in
Weston, Connecticut Weston ( ) is a New England town, town in Fairfield County, Connecticut, United States. The population was 10,354 at the 2020 United States census, 2020 census and had the highest median income in the state of Connecticut. The town is part of the ...
. Retirement allowed Evelyn to partake in her many hobbies such as oil painting, bridge, and tennis to name a few. At the age of 89, Nicol was hospitalized for a stroke, and was diagnosed with
COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the coronavirus SARS-CoV-2. In January 2020, the disease spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 can vary but often include fever ...
. She died from complications of the virus in May 2020.


References

{{DEFAULTSORT:Nicol, Evelyn American women immunologists American women microbiologists African-American biologists American women scientists Tuskegee University alumni American immunologists American microbiologists People from Bourbon County, Kentucky Deaths from the COVID-19 pandemic in Connecticut