Etifelmine Synthesis on:
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Etifelmine ( INN; also known as gilutensin) is a
The base catalyzed reaction between benzophenone 19-61-9(1) and
stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and inv ...
drug. It was used for the treatment of hypotension (low blood pressure).Synthesis
The base catalyzed reaction between benzophenone 19-61-9(1) and butyronitrile
Butyronitrile or butanenitrile or propyl cyanide, is a nitrile with the formula C3H7CN. This colorless liquid is miscible with most polar organic solvents.
Uses
Butyronitrile is mainly used as a precursor to the poultry drug amprolium.Peter Po ...
09-74-0(2) gives 2- ydroxy(diphenyl)methylutanenitrile 2101-20-8
1 (one, unit, unity) is a number representing a single or the only entity. 1 is also a numerical digit and represents a single unit of counting or measurement. For example, a line segment of ''unit length'' is a line segment of length ...
(3). Catalytic hydrogenation reduces the nitrile group to a primary amine giving 1,1-diphenyl-2-ethyl-3-aminopropanol 2101-87-7(4). The tertiary hydroxyl group is dehydrated by treatment with anhydrous hydrogen chloride gas, completing the synthesis of Etifelmine (5).See also
*2-MDP
2-MDP (U-23807A) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. The ''levo'' or (-) isomer is the active form of the drug. It also has stimulant effects, having on ...
*Pridefine
Pridefine (AHR-1,118) is a drug which was investigated as an antidepressant in the late 1970s and early 1980s, but was never marketed. It acts as a balanced reuptake inhibitor of serotonin, dopamine, and norepinephrine, and also has some weak r ...
References