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Ethacizine (ethacyzine) is a class Ic
The amide formation between Phenothiazine-2-ethylcarbamate 7711-29-8(1) and 3-Chloropropionyl chloride 25-36-5(2) gives ethyl N- 0-(3-chloropropanoyl)phenothiazin-2-ylarbamate 19407-03-3 4749-22-9(3). Displacement of the remaining ω-halogen by
antiarrhythmic agent
Antiarrhythmic agents, also known as cardiac dysrhythmia medications, are a class of drugs that are used to suppress abnormally fast rhythms (tachycardias), such as atrial fibrillation, supraventricular tachycardia and ventricular tachycardia.
M ...
, related to moracizine
Moracizine or moricizine, sold under the trade name Ethmozine, is an Antiarrhythmic agent#Class I agents, antiarrhythmic of class IC. It was used for the prophylaxis and treatment of serious and life-threatening ventricular arrhythmias, but was ...
. It is used in Russia and some other CIS countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias
Arrhythmias, also known as cardiac arrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow. Essentially, this is anything but normal sinus rhythm. A resting heart rate that is too fast – above 100 beats ...
, especially those accompanied by organic heart disease. It is also indicated as a treatment of refractory tachycardia
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate. In general, a resting heart rate over 100 beats per minute is accepted as tachycardia in adults. Heart rates above the resting rate may be normal ...
associated with Wolff–Parkinson–White syndrome
Wolff–Parkinson–White syndrome (WPWS) is a disorder due to a specific type of problem with the electrical system of the heart involving an accessory pathway able to conduct electrical current between the atria and the ventricles, thus byp ...
.
It is manufactured under the brand name Ethacizin (Этацизин) by Latvian pharmaceutical company Olainfarm.Synthesis
For the treatment of heart infarction:E I Chazov, (to 1985 to INST FARMAKOLOGII AKADEMII M).
The amide formation between Phenothiazine-2-ethylcarbamate 7711-29-8(1) and 3-Chloropropionyl chloride 25-36-5(2) gives ethyl N- 0-(3-chloropropanoyl)phenothiazin-2-ylarbamate 19407-03-3 4749-22-9(3). Displacement of the remaining ω-halogen by diethylamine
Diethylamine is an organic compound with the formula . It is classified as a secondary amine. It is a flammable, volatile weakly alkaline liquid that is miscible with most solvents. It is a colorless liquid, but commercial samples often appear br ...
(4) then completes the synthesis of ethacizine (5).
See also
*List of Russian drugs
This page is a list of Russian drugs, or drugs that were developed in Russia, the former Soviet Union, and/or post-Soviet countries.
Many Russian drugs are indicated for enhancing physical, mental, and/or cognitive performance, including drugs ...
References
Antiarrhythmic agents Carbamates Sodium channel blockers Phenothiazines Diethylamino compounds Drugs in the Soviet Union {{cardiovascular-drug-stub