In
cardiovascular physiology Cardiovascular physiology is the study of the cardiovascular system, specifically addressing the physiology of the heart ("cardio") and blood vessels ("vascular").
These subjects are sometimes addressed separately, under the names cardiac physiolog ...
, end-diastolic volume (EDV) is the volume of blood in the right or left ventricle at end of filling in
diastole
Diastole ( ) is the relaxed phase of the cardiac cycle when the chambers of the heart are refilling with blood. The contrasting phase is systole when the heart chambers are contracting. Atrial diastole is the relaxing of the atria, and ventricul ...
which is amount of blood present in ventricle at the end of diastole.
Because greater EDVs cause greater distention of the ventricle, ''EDV'' is often used synonymously with ''
preload'', which refers to the length of the
sarcomere
A sarcomere (Greek σάρξ ''sarx'' "flesh", μέρος ''meros'' "part") is the smallest functional unit of striated muscle tissue. It is the repeating unit between two Z-lines. Skeletal striated muscle, Skeletal muscles are composed of tubular ...
s in
cardiac muscle
Cardiac muscle (also called heart muscle or myocardium) is one of three types of vertebrate muscle tissues, the others being skeletal muscle and smooth muscle. It is an involuntary, striated muscle that constitutes the main tissue of the wall o ...
prior to contraction (
systole
Systole ( ) is the part of the cardiac cycle during which some chambers of the heart contract after refilling with blood. Its contrasting phase is diastole, the relaxed phase of the cardiac cycle when the chambers of the heart are refilling ...
). An increase in EDV increases the preload on the heart and, through the
Frank-Starling mechanism of the heart, increases the amount of blood ejected from the ventricle during systole (
stroke volume
In cardiovascular physiology, stroke volume (SV) is the volume of blood pumped from the ventricle (heart), ventricle per beat. Stroke volume is calculated using measurements of ventricle volumes from an Echocardiography, echocardiogram and subtra ...
).
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Sample values
The right ventricular end-diastolic volume (RVEDV) ranges between 100 and 160 mL.
The right ventricular end-diastolic volume index (RVEDVI) is calculated by RVEDV/
BSA and ranges between 60 and 100 mL/m
2.
[
]
See also
* End-systolic volume
End-systolic volume (ESV) is the volume of blood in a ventricle at the end of contraction, or systole, and the beginning of filling, or diastole.
ESV is the lowest volume of blood in the ventricle at any point in the cardiac cycle.
The main facto ...
* Stroke volume
In cardiovascular physiology, stroke volume (SV) is the volume of blood pumped from the ventricle (heart), ventricle per beat. Stroke volume is calculated using measurements of ventricle volumes from an Echocardiography, echocardiogram and subtra ...
References
{{DEFAULTSORT:End-Diastolic Volume
Cardiovascular physiology