en, Eleftheria Zeggini , image = , image_size = , caption = , birth_date = , birth_place =

Volos Volos ( el, Βόλος ) is a coastal port city in Thessaly situated midway on the Greek mainland, about north of Athens and south of Thessaloniki. It is the sixth most populous city of Greece, and the capital of the Magnesia regional unit ...

Greece Greece,, or , romanized: ', officially the Hellenic Republic, is a country in Southeast Europe. It is situated on the southern tip of the Balkans, and is located at the crossroads of Europe, Asia, and Africa. Greece shares land borders wit ...

, other_names = , residence = , citizenship = , nationality = , fields =

Digital health Digital health is a discipline that includes digital care programs, technologies with health, healthcare, living, and society to enhance the efficiency of healthcare delivery and to make medicine more personalized and precise. It uses informati ...

Human genetics Human genetics is the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population gen ...

, workplaces = , patrons = , alma_mater = , thesis_title = Genetic dissection of the major histocompatibility complex in juvenile oligoarthritis , thesis_url = https://www.worldcat.org/oclc/642917758 , thesis_year = 2002 , doctoral_advisor = , academic_advisors = , doctoral_students = , notable_students = , known_for = , influences = , influenced = , awards =

Suffrage Science award The Suffrage Science award is a prize for women in science, engineering and computing founded in 2011, on the 100th anniversary of International Women's Day by the MRC London Institute of Medical Sciences (LMS). There are three categories of awar ...

(2014) , website = , spouse = , children = Eleftheria Zeggini ( el, Ελευθερία Ζεγγίνη) is a director of the institute of translational genomics in

Helmholtz Zentrum München Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), also known as Helmholtz Munich, is a member of the Helmholtz Association of German Research Centres. It was founded in 1960 and is a joint venture by the Fed ...

and a professor at the

Technical University of Munich The Technical University of Munich (TUM or TU Munich; german: Technische Universität München) is a public research university in Munich, Germany. It specializes in engineering, technology, medicine, and applied and natural sciences. Establis ...

(TUM). Previously she served as a research group leader at the

Wellcome Trust Sanger Institute The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust. It is located on the Wellcome Ge ...

from 2008 to 2018Eleftheria Zeggini's and an

honorary professor Honorary titles (professor, reader, lecturer) in academia may be conferred on persons in recognition of contributions by a non-employee or by an employee beyond regular duties. This practice primarily exists in the UK and Germany, as well as in m ...

in the department of

health sciences The following outline is provided as an overview of and topical guide to health sciences: Health sciences are those sciences which focus on health, or health care, as core parts of their subject matter. Health sciences relate to multiple ac ...

at the

University of Leicester , mottoeng = So that they may have life , established = , type = public research university , endowment = £20.0 million , budget = £326 million , chancellor = David Willetts , vice_chancellor = Nishan Canagarajah , head_la ...

in the UK.

Education

Zeggini was educated at the

University of Manchester Institute of Science and Technology The University of Manchester Institute of Science and Technology (UMIST) was a university based in the centre of the city of Manchester in England. It specialised in technical and scientific subjects and was a major centre for research. On 1 Oct ...

(UMIST) where she was awarded a

Bachelor of Science A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University o ...

degree in

Biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology ...

in 1999. She continued her studies on the

immunogenetics Immunogenetics or immungenetics is the branch of Medical Immunology and Medical Genetics that explores the relationship between the immune system and genetics. Autoimmune diseases, such as type 1 diabetes, are complex genetic traits which res ...

of the

major histocompatibility complex The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are call ...

childhood arthritis Childhood arthritis (also known as juvenile arthritis, JRA, Juvenile Idiopathic Disease or Arthritis, or Still's Disease) is any form of chronic arthritis or chronic arthritis-related conditions which affects individuals under the age of 16. Most ...

at the

Arthritis Research UK Versus Arthritis is the UK's largest charity dedicated to supporting people with arthritis. It was launched in September 2018, following the legal merger of the two leading arthritis charities in the UK, Arthritis Research UK and Arthritis Care ...

epidemiology unit at the

University of Manchester The University of Manchester is a public university, public research university in Manchester, England. The main campus is south of Manchester city centre, Manchester City Centre on Wilmslow Road, Oxford Road. The university owns and operates majo ...

, and was awarded a

PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * ''Piled Higher and Deeper ''Piled Higher and Deeper'' (also known as ''PhD Comics''), is a newsp ...

in 2002.

Career and research

Following her PhD, Zeggini was a

postdoctoral researcher A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...

at the

Wellcome Trust Centre for Human Genetics Wellcome () is a supermarket chain owned by British conglomerate Jardine Matheson Holdings via its DFI Retail Group subsidiary. The Wellcome supermarket chain is one of the two largest supermarket chains in Hong Kong, the other being Parkn ...

at the

University of Oxford The University of Oxford is a collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the world's second-oldest university in contin ...

where she later became a

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glax ...

research career development

fellow A fellow is a concept whose exact meaning depends on context. In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements. Within the context of higher education ...

. She has been a group leader at the Sanger since 2008. , according to

Google scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines. Released in beta in November 2004, the Google Scholar index includes p ...

and

Scopus Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-l ...

her most cited work has been published in ''

Science Science is a systematic endeavor that Scientific method, builds and organizes knowledge in the form of Testability, testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earli ...

'' and ''

Nature Genetics ''Nature Genetics'' is a peer-reviewed scientific journal published by Nature Portfolio. It was established in 1992. It covers research in genetics. The chief editor is Tiago Faial. The journal encompasses genetic and functional genomic studies o ...

''. her work investigates the

genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar worki ...

of complex phenotypic traits in humans using

genetic association Genetic association is when one or more genotypes within a population co-occur with a phenotypic trait more often than would be expected by chance occurrence. Studies of genetic association aim to test whether single-locus alleles or genotype f ...

studies to identify novel disease loci. In a study published in 2017, her team reported the discovery of a genetic variant in

Mediterranean The Mediterranean Sea is a sea connected to the Atlantic Ocean, surrounded by the Mediterranean Basin and almost completely enclosed by land: on the north by Western and Southern Europe and Anatolia, on the south by North Africa, and on th ...

Cretan Crete ( el, Κρήτη, translit=, Modern: , Ancient: ) is the largest and most populous of the Greek islands, the 88th largest island in the world and the fifth largest island in the Mediterranean Sea, after Sicily, Sardinia, Cyprus, and ...

villagers that protected them against the harmful effects of 'bad' fats and

cholesterol Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell membr ...

as well as decrease the risk of

cardiovascular disease Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, ...

Awards and honours

Zeggini won the

in 2014.

Personal life

Zeggini was born and raised in

References

{{DEFAULTSORT:Zeggini, Eleftheria Living people Year of birth missing (living people) 21st-century British biologists 21st-century British women scientists British geneticists British women biologists Genetic epidemiologists British people of Greek descent