Edwin Gerhard Krebs (June 6, 1918 – December 21, 2009) was an American biochemist. He received the

Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the Lasker Award, prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Phys ...

and the

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...

Columbia University Columbia University in the City of New York, commonly referred to as Columbia University, is a Private university, private Ivy League research university in New York City. Established in 1754 as King's College on the grounds of Trinity Churc ...

in 1989 together with Alfred Gilman and, together with his collaborator

Edmond H. Fischer Edmond Henri Fischer (April 6, 1920 – August 27, 2021) was a Swiss-American biochemist. He and his collaborator Edwin G. Krebs were awarded the Nobel Prize in Physiology or Medicine in 1992 for describing how reversible phosphorylation works ...

, was awarded the

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...

in 1992 for describing how reversible

phosphorylation In biochemistry, phosphorylation is described as the "transfer of a phosphate group" from a donor to an acceptor. A common phosphorylating agent (phosphate donor) is ATP and a common family of acceptor are alcohols: : This equation can be writ ...

works as a switch to activate

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

s and regulate various cellular processes.

Early life and education

Krebs was born in

Lansing, Iowa Lansing is a city in Lansing Township, Allamakee County, Iowa, United States. The population was 968 at the time of the 2020 census. History Lansing was platted ''circa'' 1851. The city was so named because the first settler was a native of La ...

, the third child of William Carl Krebs, a

Presbyterian Presbyterianism is a historically Reformed Protestant tradition named for its form of church government by representative assemblies of elders, known as "presbyters". Though other Reformed churches are structurally similar, the word ''Pr ...

minister and Louise Helen (Stegeman) Krebs. The family moved frequently due to the nature of his father's work, though they settled in

Greenville, Illinois : Greenville is a city in Bond County, Illinois, United States, east of St. Louis. The population as of the 2020 census was 7,083, up from 7,000 at the 2010 census. It is the county seat of Bond County. Greenville is part of the St. Louis ...

when Krebs was six and remained there until his father's unexpected death in 1933. Louise Krebs decided to move her family to

Urbana, Illinois Urbana ( ) is a city in Champaign County, Illinois, United States, and its county seat. As of the 2020 census, Urbana had a population of 38,336. It is a principal city of the Champaign–Urbana metropolitan area, which had 236,000 residents i ...

, where Krebs's elder brothers were attending the

University of Illinois Urbana–Champaign The University of Illinois Urbana-Champaign (UIUC, U of I, Illinois, or University of Illinois) is a public land-grant research university in the Champaign–Urbana metropolitan area, Illinois, United States. Established in 1867, it is the fo ...

. Krebs attended Urbana High School, and enrolled at the University of Illinois Urbana–Champaign in 1936. In his fourth year of study Krebs had decided to either pursue a higher degree in

organic chemistry Organic chemistry is a subdiscipline within chemistry involving the science, scientific study of the structure, properties, and reactions of organic compounds and organic matter, organic materials, i.e., matter in its various forms that contain ...

or study medicine. Receiving a scholarship to attend

Washington University School of Medicine Washington University School of Medicine (WashU Medicine) is the medical school of Washington University in St. Louis, located in the Central West End neighborhood of St. Louis, Missouri. Founded in 1891, the School of Medicine shares a ca ...

St. Louis St. Louis ( , sometimes referred to as St. Louis City, Saint Louis or STL) is an independent city in the U.S. state of Missouri. It lies near the confluence of the Mississippi and the Missouri rivers. In 2020, the city proper had a populatio ...

, he chose the latter. The School of Medicine afforded Krebs the opportunity to train as a physician as well as to gain experience in medical research. Following graduation in 1943, he undertook an 18-month residency at Barnes Hospital in St. Louis and then went on active duty as a medical officer in the

Navy A navy, naval force, military maritime fleet, war navy, or maritime force is the military branch, branch of a nation's armed forces principally designated for naval warfare, naval and amphibious warfare; namely, lake-borne, riverine, littoral z ...

. Krebs was discharged from the Navy in 1946 and was unable to immediately return to hospital work; he was advised to study basic science instead. He chose to study

biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

and was postdoctoral fellow to

Carl Carl may refer to: *Carl, Georgia, city in USA *Carl, West Virginia, an unincorporated community *Carl (name), includes info about the name, variations of the name, and a list of people with the name *Carl², a TV series * "Carl", an episode of tel ...

and

Gerty Cori Gerty Theresa Cori (; August 15, 1896 – October 26, 1957) was a Bohemian-Austrian and American biochemist who in 1947 was the third woman to win a Nobel Prize in science, and the first woman to be awarded the Nobel Prize in Physiology or Me ...

, working on the interaction of

protamine Protamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for sperm head condensation and DNA stabilization. They may allow for denser packaging of DNA ...

with rabbit muscle

phosphorylase In biochemistry, phosphorylases are enzymes that catalyze the addition of a phosphate group from an inorganic phosphate (phosphate+hydrogen) to an acceptor. :A-B + P A + P-B They include allosteric enzymes that catalyze the production of glu ...

. At the completion of his two years' study, Krebs decided to continue his career as a biochemist.

Research work

In 1948 Krebs accepted a position as assistant professor of biochemistry at the

University of Washington The University of Washington (UW and informally U-Dub or U Dub) is a public research university in Seattle, Washington, United States. Founded in 1861, the University of Washington is one of the oldest universities on the West Coast of the Uni ...

Seattle Seattle ( ) is the most populous city in the U.S. state of Washington and in the Pacific Northwest region of North America. With a population of 780,995 in 2024, it is the 18th-most populous city in the United States. The city is the cou ...

. When

arrived at the department in 1953, the pair decided to work on the enzymology of

. During the course of their study they were able to observe the mechanism by which interconversion of the two forms of phosphorylase takes place: reversible protein phosphorylation. Explained simply, in reversible protein phosphorylation a

protein kinase A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them ( phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a f ...

takes a

phosphate Phosphates are the naturally occurring form of the element phosphorus. In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthop ...

group from

adenosine triphosphate Adenosine triphosphate (ATP) is a nucleoside triphosphate that provides energy to drive and support many processes in living cell (biology), cells, such as muscle contraction, nerve impulse propagation, and chemical synthesis. Found in all known ...

(ATP) and attaches it to a specific site on a protein, introducing both extra mass and negative charge at that site. This can alter the protein's shape and turn its function in a biological process up or down, either by changing its activity or its ability to bind to another protein. The protein can be converted back to its original state by a protein

phosphatase In biochemistry, a phosphatase is an enzyme that uses water to cleave a phosphoric acid Ester, monoester into a phosphate ion and an Alcohol (chemistry), alcohol. Because a phosphatase enzyme catalysis, catalyzes the hydrolysis of its Substrate ...

that removes the phosphate. This cycle controls numerous metabolic processes, and plays a central role in the regulation of cell division, shape, and motility. Derangement of specific protein phosphorylation pathways is important in human disease, including cancer and diabetes. Fischer and Krebs were awarded the Nobel Prize for Physiology or Medicine in 1992 for the discovery of reversible protein phosphorylation.

Later life and death

Krebs's interest in teaching and administration led him to leave the University of Washington to become the founding chairman of the department of biochemistry at the

University of California, Davis The University of California, Davis (UC Davis, UCD, or Davis) is a Public university, public Land-grant university, land-grant research university in Davis, California, United States. It is the northernmost of the ten campuses of the University ...

. In 1977 he returned to the University of Washington as chairman of the department of

pharmacology Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur betwee ...

. Krebs was hearing impaired. Krebs died on December 21, 2009. His wife, Virginia, died in 2018. He is survived by three children.

References and notes

Bibliography

* * * * * *

External links

* Hughes, R. 1998.
After the Prize
' *
The Official Site of Louisa Gross Horwitz Prize

Edmond H. Fischer, "Edwin G. Krebs", Biographical Memoirs of the National Academy of Sciences (2010)
{{DEFAULTSORT:Krebs, Edwin G. 1918 births 2009 deaths American biochemists Washington University School of Medicine alumni University of Washington faculty Nobel laureates in Physiology or Medicine American Nobel laureates People from Urbana, Illinois People from Bond County, Illinois University of Illinois Urbana-Champaign alumni Members of the United States National Academy of Sciences American Presbyterians American people of German descent Howard Hughes Medical Investigators People from Allamakee County, Iowa Recipients of the Albert Lasker Award for Basic Medical Research Washington University in St. Louis alumni University of California, Davis faculty