An eccrine nevus is an extremely rare cutaneous condition that,

histologically Histology, also known as microscopic anatomy or microanatomy, is the branch of biology that studies the microscopic anatomy of biological tissue (biology), tissues. Histology is the microscopic counterpart to gross anatomy, which looks at large ...

, is characterized by an increase in size or number of

eccrine Merocrine (or eccrine) is a term used to classify exocrine glands and their secretions in the study of histology. A cell is classified as merocrine if the secretions of that cell are excreted via exocytosis from secretory cells into an epitheli ...

secretory coils.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. .

Hyperhidrosis Hyperhidrosis is a medical condition in which a person exhibits excessive perspiration, sweating, more than is required for the Thermoregulation, regulation of body temperature. Although it is primarily a physical burden, hyperhidrosis can deterio ...

is the most common symptom. It can present as discoloured nodules,

papules A papule is a small, well-defined bump in the skin. It may have a rounded, pointed or flat top, and may have a dip. It can appear with a stalk, be thread-like or look warty. It can be soft or firm and its surface may be rough or smooth. Some ...

, or plaques. Eccrine nevus mostly affects the extremities. Eccrine nevus are diagnosed based of

histology Histology, also known as microscopic anatomy or microanatomy, is the branch of biology that studies the microscopic anatomy of biological tissue (biology), tissues. Histology is the microscopic counterpart to gross anatomy, which looks at large ...

. Treatment includes surgical excision or topical medications.

Signs and symptoms

The clinical signs of eccrine nevus might vary, involving a single nodular lesion or a broad patch encompassing the majority of the trunk. Discolored nodules,

, and plaques may also be present. The most often reported symptom, though not always present, is

hyperhidrosis Hyperhidrosis is a medical condition in which a person exhibits excessive perspiration, sweating, more than is required for the Thermoregulation, regulation of body temperature. Although it is primarily a physical burden, hyperhidrosis can deterio ...

. The majority of eccrine nevi are found in the extremities, with a preference for the forearms.

Causes

The cause of eccrine nevus is uncertain. The postulated pathogenic variables include congenital abnormalities in

embryogenesis An embryo ( ) is the initial stage of development for a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male ...

, trauma, and stress, although none have been verified.

Diagnosis

Eccrine nevi are identified histologically, with findings indicating just an increase in the size and/or number of structurally normal eccrine glands. However, there have been cases reported with structural abnormalities, including adenomatous alterations, pseudobasaloid cell nests, and twisted ducts.

Treatment

The course of treatment for eccrine nevus is determined by the patient's preferences, associated symptoms, and the extent of the lesion. Surgical excision may be the best course of action when the lesion is tiny. Conversely, topical therapies such

botulinum toxin Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium ''Clostridium botulinum'' and related species. It prevents the release of the neurotransmitter acetylcholine from axon en ...

or anticholinergic medicines may be used when localized

coexists with a big skin lesion.

References

External links

{{Medical resources , ICD11 = {{ICD11, LC0Y , ICD10 = {{ICD10, Q82.5 , ICD10CM = , ICD9 = , ICDO = , OMIM = , MeshID = , DiseasesDB = 34410 , SNOMED CT = 239116006 , Curlie = , MedlinePlus = , eMedicineSubj = , eMedicineTopic = , PatientUK = , NCI = , GeneReviewsNBK = , GeneReviewsName = , NORD = , GARDNum = , GARDName = , RP = , AO = , WO = , OrthoInfo = , Orphanet = , Scholia = Q5332316 , OB = Epidermal nevi, neoplasms, and cysts