Transcription factor E2F1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''E2F1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene is a member of the E2F family of
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...
s. The E2F family plays a crucial role in the control of
cell cycle
The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA ( DNA replication) and some of its organelles, and sub ...
and action of
tumor suppressor
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or re ...
proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains found in most members of the family. These domains include a
DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to
retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and
p53-dependent/independent
apoptosis.
Transcription
E2F1 promoter
AX8=> E2F1
Interactions
E2F1 has been shown to
interact with:
*
ARID3A,
*
CUL1,
[
* Cyclin A1,][
* ]SP4 SP4 may refer to:
* SP4, an album by Sneaker Pimps
* Sp4 transcription factor, a human gene
* Savoia-Pomilio SP.4, a reconnaissance and bomber aircraft built in Italy during the First World War
* The Saint Patrick's Day Four
* Service pack 4 in c ...
,[
* TFDP1][ and
* UBC.]
See also
* E2F
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as suppressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation a ...
* Retinoblastoma protein
References
Further reading
*
*
*
*
External links
*
*
{{DEFAULTSORT:E2f1
Transcription factors