Dock6 (
Dedicator
of
cyto
kinesis 6), also known as Zir1 is a large (~200 kDa)
protein involved in
intracellular signalling networks.
It is a member of the DOCK-C subfamily of the
DOCK
A dock (from Dutch language, Dutch ''dok'') is the area of water between or next to one or a group of human-made structures that are involved in the handling of boats or ships (usually on or near a shore) or such structures themselves. The ex ...
family of
guanine nucleotide exchange factors which function as activators of small
G proteins.
Discovery
Dock6 was identified as one of a family of proteins which share high
sequence similarity with
Dock180
Dock180, (Dedicator of cytokinesis) also known as DOCK1, is a large (~180 kDa) protein involved in intracellular signalling networks. It is the mammalian ortholog of the ''C. elegans'' protein CED-5 and belongs to the DOCK family of Guanine nucl ...
, the archetypal member of the DOCK family.
It has a similar domain arrangement to other DOCK proteins,
with a
DHR1 domain known in other proteins to bind
phospholipids,
and a
DHR2 domain containing the GEF activity.
Function
There is currently very little information about the cellular role of this protein. However, Dock6 has been reported to exhibit dual GEF specificity towards the small G proteins
Rac1 and
Cdc42.
It is the only DOCK family member reported to activate both of these G proteins. The same study also showed that
transfection of the Dock6 DHR2 domain into N1E-115
neuroblastoma cells promoted Rac- and Cdc42-dependent
neurite outgrowth, although the physiological significance of this has yet to be demonstrated.
References
Further reading
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