Dihydrochalcone (DHC) is the
organic compound
Some chemical authorities define an organic compound as a chemical compound that contains a carbon–hydrogen or carbon–carbon bond; others consider an organic compound to be any chemical compound that contains carbon. For example, carbon-co ...
with the formula C
6H
5C(O)(CH
2)
2C
6H
5. It is the reduced derivative of
chalcone
Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids. They are widely known bioactive substances, fluorescent materi ...
(C
6H
5C(O)(CH)
2C
6H
5). It is a white solid that is soluble in many organic solvents. Dihydrochalcone per se is often minor significance, but some derivatives occur in nature and have attracted attention as drugs.
Natural dihydrochalcones
left, is a commercial artificial sweetener">Neohesperidin dihydrochalcone is a commercial artificial sweetener that features the dihydrochalcone substituent.
* Aspalathin, a C-linked dihydrochalcone glucoside found in rooibos, a common herbal tea
* Naringin dihydrochalcone, an artificial sweetener derived from naringin
* Neohesperidin dihydrochalcone, an artificial sweetener derived from citrus
*
Nothofagin, a C-linked phloretin glucoside found in rooibos
*
Phloretin
Phloretin is a dihydrochalcone, a type of natural phenol. It can be found in apple tree leaves and the Manchurian apricot.
Metabolism
In rats, ingested phlorizin is converted into phloretin by hydrolytic enzymes in the small intestine. Ph ...
* Isosalipurpurin
Dihydrochalcones (3′,5′-dihydroxy-2′,4′,6′-trimethoxydihydrochalcone (methyl linderone) and 2′-hydroxy-3′,4′,5′,6′-tetramethoxydihydrochalcone (
dihydrokanakugiol) can be found in twigs of ''
Lindera lucida''.
[A dihydrochalcone from Lindera lucida. Yuan-Wah Leong, Leslie J. Harrison, Graham J. Bennett, Azizol A. Kadir and Joseph D. Connolly, Phytochemistry, Volume 47, Issue 5, March 1998, Pp. 891-894, ]
References
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