David V. Goeddel (born 1951) is an American molecular biologist who, employed at the time by

Genentech Genentech, Inc., is an American biotechnology corporation headquartered in South San Francisco, California. It became an independent subsidiary of Roche in 2009. Genentech Research and Early Development operates as an independent center within ...

, successfully used

genetic engineering Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology. It is a set of technologies used to change the genetic makeup of cells, including ...

to coax bacteria into creating synthetic human

insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabol ...

, human

growth hormone Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in ...

, and human

tissue plasminogen activator Tissue plasminogen activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease () found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion o ...

(tPA) for use in therapeutic medicine. Recruited by Bob Swanson in 1978, he was the first non-university scientist to be hired at Genentech, and the company's third employee. Goeddel became legendary in the biotechnology and

molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and phys ...

fields by cloning virtually all of Genentech's early products and/or processes, including synthetic

, and tPA, often beating out bigger and more established laboratories in the process. Besides being perhaps the single most important contributor to Genentech's rise to one of the nation's premier biotech companies, his extraordinary drive and competitive work ethic embodied Genentech's early "Clone or Die" cultureInvisible Frontiers: The Race to Synthesize a Human Gene by Stephen S. Hall (1987, Tempus Books of

Microsoft Press Microsoft Press is the publishing arm of Microsoft, usually releasing books dealing with various current Microsoft technologies. Microsoft Press' first introduced books were ''The Apple Macintosh Book'' by Cary Lu and ''Exploring the IBM PCjr Ho ...

) Together with Steve McKnight and

Robert Tjian Robert Tjian (; born 1949) is a Hong Kong-born American biochemist best known for his work on eukaryotic transcription. He is currently Professor of Biochemistry and Molecular Biology at the University of California, Berkeley and an Investigato ...

, he founded Tularik in 1991, and was their president and CEO until Tularik was acquired by

Amgen Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. One of the world's largest independent biotechnology companies, Amgen was established in ...

for $1.3 billion in 2004. Goeddel earned his

bachelor's degree A bachelor's degree (from Middle Latin ''baccalaureus'') or baccalaureate (from Modern Latin ''baccalaureatus'') is an undergraduate academic degree awarded by colleges and universities upon completion of a course of study lasting three to six ...

in chemistry from the

University of California, San Diego The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Insti ...

, and his PhD in biochemistry from the

University of Colorado, Boulder The University of Colorado Boulder (CU Boulder, CU, or Colorado) is a public research university in Boulder, Colorado. Founded in 1876, five months before Colorado became a state, it is the flagship university of the University of Colorado sys ...

. He is a member of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...

, and is a recipient of the

Eli Lilly Award in Biological Chemistry The Eli Lilly Award in Biological Chemistry was established in 1934. Consisting of a bronze medal and honorarium, its purpose is to stimulate fundamental research in biological chemistry by scientists not over thirty-eight years of age. The Award i ...

and the Scheele Award from the Swedish Academy of Pharmaceutical Sciences.

Personal life

Goeddel has two sons who have played

Major League Baseball Major League Baseball (MLB) is a professional baseball organization and the oldest major professional sports league in the world. MLB is composed of 30 total teams, divided equally between the National League (NL) and the American League (AL) ...

, Erik and

Tyler Tyler may refer to: People and fictional characters * Tyler (name), an English name; with lists of people with the surname or given name * Tyler, the Creator (born 1991), American rap artist and producer * John Tyler, 10th president of the United ...

References

{{DEFAULTSORT:Goeddel, David 1951 births People from San Diego Living people University of California, San Diego alumni Members of the United States National Academy of Sciences Genentech people University of Colorado Boulder alumni Fellows of the American Academy of Microbiology