David Charles (physician)
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David Charles is an American neurologist, professor and vice-chair of neurology, and the medical director of Telehealth at
Vanderbilt University Medical Center The Vanderbilt University Medical Center (VUMC) is a medical provider with multiple hospitals in Nashville, Tennessee, as well as clinics and facilities throughout Middle Tennessee. VUMC is an independent non-profit organization, but maintains a ...
.


Education

David Charles attended
Vanderbilt University School of Medicine Vanderbilt University School of Medicine (VUSM) is the graduate medical school of Vanderbilt University, a private research university located in Nashville, Tennessee. The School of Medicine is primarily housed within the Eskind Biomedical Libra ...
, graduating in 1990. After completing his neurology residency at
Vanderbilt University Medical Center The Vanderbilt University Medical Center (VUMC) is a medical provider with multiple hospitals in Nashville, Tennessee, as well as clinics and facilities throughout Middle Tennessee. VUMC is an independent non-profit organization, but maintains a ...
, he joined the faculty of the Department of Neurology at Vanderbilt University in 1994. In 1995, he obtained his fellowship in Movement Disorders and Clinical Neurophysiology. In 1996, he completed the Health Care Management Program from the
Owen Graduate School of Management The Vanderbilt University Owen Graduate School of Management is the graduate business school of Vanderbilt University in Nashville, Tennessee, United States. Founded in 1969, Owen offers six degrees: a standard 2-year Master of Business Administr ...
. In January and May 1997, he completed Harvard Macy Institute's Program for Physician Educators, and in 1998, he studied
deep brain stimulation Deep brain stimulation (DBS) is a type of neurostimulation therapy in which an implantable pulse generator is stereotactic surgery, surgically implanted subcutaneous tissue, below the skin of the chest and connected by Lead (electronics), leads ...
, and its use as a treatment of
Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...
as a
Fulbright Senior Scholar The Fulbright Program, including the Fulbright–Hays Program, is one of several United States cultural exchange programs with the goal of improving intercultural relations, cultural diplomacy, and intercultural competence between the people o ...
at the Universitaire de Grenoble in Grenoble, France.


Professional activities

Charles is president of the Clinical Neurological Society of America, co-chair of the
North American Neuromodulation Society North American Neuromodulation Society (NANS) is a professional scientific organization that serves to promote and advance neuromodulation as a treatment for various diseases. The majority of its members work in pain-related disciplines, althoug ...
Neurology Committee, past chairman of the Public Policy Committee of the
American Neurological Association The American Neurological Association (ANA) is a professional society of academic neurologists and neuroscientists devoted to advancing the goals of academic neurology; to training and educating neurologists and other physicians in the neurologic ...
, a Fellow of the
American Academy of Neurology The American Academy of Neurology (AAN) is a professional society representing over 40,000 neurologists and neuroscientists. As a medical specialty society it was established in 1948 by A.B. Baker of the University of Minnesota to advance the a ...
and the
American Neurological Association The American Neurological Association (ANA) is a professional society of academic neurologists and neuroscientists devoted to advancing the goals of academic neurology; to training and educating neurologists and other physicians in the neurologic ...
, and past board member of the United Council of Neurologic Subspecialties. He is a past-president of The Tennessee Academy of Neurology. From 1997 to 1998, he was a Health Policy Fellow on the staff of the Labor Subcommittee for Public Health and Safety, United States Senate. At Vanderbilt he serves as vice-chair of neurology, and previously served as the assistant dean of admissions for the medical school and the Neurology Residency Program Director.


Alliance for Patient Access

He is also the chair of the Alliance for Patient Access, which, according to ''
The Wall Street Journal ''The Wall Street Journal'' (''WSJ''), also referred to simply as the ''Journal,'' is an American newspaper based in New York City. The newspaper provides extensive coverage of news, especially business and finance. It operates on a subscriptio ...
'' "represents physicians and is largely funded by the pharmaceutical industry. The contributors mostly include brand-name drug makers and biotechs, but some – such as Pfizer and Amgen – are also developing biosimilars." In 2013 he published an article on
specialty drugs Specialty drugs or specialty pharmaceuticals are a recent designation of pharmaceuticals classified as high-cost, high complexity and/or high touch. Specialty drugs are often biologics—"drugs derived from living cells" that are injectable or in ...
in which he agreed with the findings of the
Congressional Budget Office The Congressional Budget Office (CBO) is a List of United States federal agencies, federal agency within the United States Congress, legislative branch of the United States government that provides budget and economic information to Congress. I ...
that spending on prescription medications "saves costs in other areas of healthcare spending." He observed that specialty drugs are so high priced that many patients do not fill prescriptions resulting in more serious health problems increasing. His article referred to specialty drugs such as "new cancer drugs specially formulated for patients with specific genetic markers." He explained the high cost of these "individualized medications based on diagnostic testing; and "biologics," or medicines created through biologic processes, rather than chemically synthesized like most pharmaceuticals." He argued that there should be a slight increase in co-pays for the more commonly using lower-tier medications to allow a lower co-pay for those who "require high-cost specialty tier medications."


Research

Charles' research is primarily focused on
movement disorders Movement disorders are clinical syndromes with either an excess of movement or a paucity of voluntary and involuntary movements, unrelated to weakness or spasticity. Movement disorders present with extrapyramidal symptoms and are caused by basal ...
including
Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...
,
cervical dystonia Spasmodic torticollis is an extremely painful chronic neurological movement disorder causing the neck to involuntarily turn to the left, right, upwards, and/or downwards. The condition is also referred to as "cervical dystonia". Both agonist and ...
,
tremor A tremor is an involuntary, somewhat rhythmic muscle contraction and relaxation involving neural oscillations, oscillations or twitching movements of one or more body parts. It is the most common of all involuntary movements and can affect the h ...
,
spasticity Spasticity () is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia. It is also colloquially referred to as an unusual "tightness", stiffness, or "pull" of muscles. ...
, and neurotoxin injections. One of his focuses within
movement disorders Movement disorders are clinical syndromes with either an excess of movement or a paucity of voluntary and involuntary movements, unrelated to weakness or spasticity. Movement disorders present with extrapyramidal symptoms and are caused by basal ...
, particularly with
Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...
, has been
Deep Brain Stimulation Deep brain stimulation (DBS) is a type of neurostimulation therapy in which an implantable pulse generator is stereotactic surgery, surgically implanted subcutaneous tissue, below the skin of the chest and connected by Lead (electronics), leads ...
(DBS). An article in ''NeurologyToday'' interviewed him on "20 Years of Monumental Strides in Movement Disorders." In the interview, David Charles hailed that the United States approving DBS in 2016 for mid-stage Parkinson's disease was "one of the biggest advances" in DBS. He also states that DBS is a better alternative to medication, "the data are very clear that DBS plus medicine is superior to medicine alone in controlling symptoms and improving quality of life in mid- and advanced-stage disease," backing this up with his publication, "Subthalamic Nucleus Deep Brain Stimulation May Reduce Medication Costs in Early Stage Parkinson’s Disease." He has authored over 100 research publications and is currently the principal investigator in the only FDA approved clinical trial testing the efficacy of
Deep Brain Stimulation Deep brain stimulation (DBS) is a type of neurostimulation therapy in which an implantable pulse generator is stereotactic surgery, surgically implanted subcutaneous tissue, below the skin of the chest and connected by Lead (electronics), leads ...
in people with early stage Parkinson's disease.


References


External links


faculty web page
{{DEFAULTSORT:Charles, David People from Decatur, Alabama Physicians from Alabama Vanderbilt University School of Medicine alumni Harvard Medical School alumni Vanderbilt University faculty Living people 1964 births