Datumetine is a

tropane alkaloid Tropane alkaloids are a class of bicyclic .2.1alkaloids and secondary metabolites that contain a tropane ring in their chemical structure. Tropane alkaloids occur naturally in many members of the plant family Solanaceae. Certain tropane alkaloi ...

found in leaves of ''

Datura metel ''Datura metel'' is a shrub-like annual (zone 5–7) or short-lived, shrubby perennial (zone 8–10), commonly known in Europe as Indian thornapple, Hindu Datura, or metel and in the United States as devil's trumpet or angel's trumpet. ''Datura ...

''. It is said to modulate

NMDA receptor The ''N''-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other ...

and thus causes memory loss. It also causes epileptic seizures in mice. Docking studies suggest that it fits on both

allosteric In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the p ...

and

orthosteric In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the p ...

sites of NMDA receptor. It acts together with other

anticholinergic Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central nervous system, central and peripheral nervous system. These agents inhibit the parasympatheti ...

tropane alkaloids of datura to cause amnesia.

References

Tropane alkaloids found in Solanaceae 4-Methoxyphenyl compounds Phenyl compounds NMDA receptor modulators {{Alkaloid-stub

See also

References