Daphnetin is a chemical compound with the molecular formula . It has been isolated from plants of the genus ''

Daphne Daphne (; ; , , ), a figure in Greek mythology, is a naiad, a variety of female nymph associated with fountains, wells, springs, streams, brooks and other bodies of freshwater. There are several versions of the myth in which she appears, but t ...

''. It has also been found in ''

Matricaria chamomilla ''Matricaria chamomilla'' (synonym: ''Matricaria recutita''), commonly known as chamomile (also spelled camomile), German chamomile, Hungarian chamomile (kamilla), wild chamomile, blue chamomile, or scented mayweed, is an annual plant of the com ...

'' (chamomile). It a crystalline solid with a melting point of 256 °C. It is soluble in boiling water. Daphnetin can undergo enzymatic

glycosylation Glycosylation is the reaction in which a carbohydrate (or ' glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor) in order to form a glycoconjugate. In biology (but not ...

to yield its 7-''O''-glucoside which is called daphnin (daphnetin 7-β-D-glucopyranoside). The reaction is catalyzed by the enzyme O-dihydroxy coumarin 7-O-glucosyltransferase. Daphnetin shows several neuroprotective and anti-inflammatory effects on the inhibition of the TLR4/NF-κB mediated inflammatory signaling pathway. They also could inhibit the IKKs/IkBa/NF-κB, AKT, and the Src/FAK/ERK1/2 multi-target medication signaling pathway for anti-angiogenesis and cancer. Daphnetin has been reported to be a strong sensitizer, which means that this compound and its glycosidic derivatives (e.g. daphnin) can be a cause of allergic reactions.

References

{{reflist Coumarins Polyphenols Diols