Daniel D. Von Hoff is the physician in chief and director of translational research at

Translational Genomics Research Institute The Translational Genomics Research Institute (TGen) is a non-profit genomics research institute based in Phoenix, Arizona, United States. History and activities TGen was established in July 2002 by Jeffrey Trent in Phoenix, Arizona, w ...

(TGen), and current Virginia G. Piper Distinguished Chair for Innovative Cancer Research at HonorHealth Clinical Research Institute. He is also a professor of medicine at the

Mayo Clinic Mayo Clinic () is a Nonprofit organization, private American Academic health science centre, academic Medical centers in the United States, medical center focused on integrated health care, healthcare, Mayo Clinic College of Medicine and Science ...

and medical director of research as well as chief scientific officer at US Oncology. He is most notable for his work in targeted therapies for the treatment of cancer. He led the development of

gemcitabine Gemcitabine, sold under the brand name Gemzar, among others, is a chemotherapy medication used to treat cancers. It is used to treat testicular cancer, breast cancer, ovarian cancer, non-small cell lung cancer, pancreatic cancer, and bladder ca ...

, and has several drugs in development.

Education

Von Hoff received his bachelor's degree from

Carroll College Carroll College is a private Catholic college in Helena, Montana. The college has 21 buildings on a 63-acre campus, has over 35 academic majors, participates in 15 NAIA athletic sports, and is home to All Saints Chapel. The college motto, in L ...

, and his MD from

Columbia University College of Physicians and Surgeons The Columbia University College of Physicians and Surgeons (officially known as Columbia University Roy and Diana Vagelos College of Physicians and Surgeons) is the medical school of Columbia University, located at the Columbia University Irvin ...

in 1973. He did a residency in internal medicine at

UC San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California, United States. It is part of the University of California system and is dedicated entirely to health science and life s ...

, followed by a fellowship in oncology at the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...

Career

After his fellowship, Von Hoff joined the faculty at University of Texas Health Science Center, San Antonio (UTHSCSA) as a professor of medicine and cellular and structural biology. In 1989, he became the founding director of UTHSCSA's Institute for Drug Development at the Cancer Therapy and Research Center. He later became the director of the cancer center and professor of medicine at the

University of Arizona The University of Arizona (Arizona, U of A, UArizona, or UA) is a Public university, public Land-grant university, land-grant research university in Tucson, Arizona, United States. Founded in 1885 by the 13th Arizona Territorial Legislature, it ...

. Dr. Von Hoff has served on the Medical Advisory Board of the Seena Magowitz Foundation since 2014. Von Hoff has been part of more than 200 clinical trials. Some of the drugs he has been involved in the development of include

mitoxantrone Mitoxantrone (INN, BAN, USAN; also known as Mitozantrone in Australia; trade name Novantrone) is an anthracenedione antineoplastic agent. Uses Mitoxantrone is used to treat certain types of cancer, mostly acute myeloid leukemia. It improves th ...

fludarabine Fludarabine is a purine analogue and antineoplastic agent. It is generally used as its 5-O-phosphorylated form known as fludarabine phosphate, sold under the brand name Fludara among others. It is a chemotherapy medication used in the treatm ...

paclitaxel Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered b ...

docetaxel Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cel ...

irinotecan Irinotecan, sold under the brand name Camptosar among others, is an anti-cancer medication used to treat colon cancer and small cell lung cancer. For colon cancer it is used either alone or with fluorouracil. For small cell lung cancer it is ...

nelarabine Nelarabine, sold under the brand names Arranon (US) and Atriance (EU), is a chemotherapy medication used for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). Nelarabine is a prodrug of ar ...

capecitabine Capecitabine, sold under the brand name Xeloda among others, is a anticancer medication used to treat breast cancer, gastric cancer and colorectal cancer. For breast cancer it is often used together with docetaxel. It is taken by mouth. ...

, and

vismodegib Vismodegib, sold under the brand name Erivedge, is a medication used for the treatment of basal-cell carcinoma (BCC). The approval of vismodegib on January 30, 2012, represents the first Hedgehog signaling pathway targeting agent to gain U.S. Foo ...

Awards

* 1980 Elected Fellow,

American College of Physicians The American College of Physicians (ACP) is a Philadelphia-based national organization of internal medicine physicians, who specialize in the diagnosis, treatment, and care of adults. With 161,000 members, ACP is the largest medical-specialty or ...

* 1992 Elected Fellow,

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is a United States–based international nonprofit with the stated mission of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsib ...

* 1997 AACR–Richard and Hinda Rosenthal Award * 1999 President,

American Association for Cancer Research The American Association for Cancer Research (AACR) is the world's oldest and largest professional association related to cancer research. Based in Philadelphia, the AACR focuses on all aspects of cancer research, including Basic research, basic, ...

* 2003 Weinberg Award,

Dana Farber Cancer Institute Dana may refer to: Businesses and organisations * Dana (company), a Slovenian beverage company * Dana (payment service), in Indonesia * Dana Air, a Nigerian airline * Dana College, formerly in Nebraska, U.S. * Dana Energy, an Iranian oil and ga ...

* 2004–2010 Member of the National Cancer Advisory Board * 2009 Stand Up to Cancer Dream Team Grant Award – Pancreatic Cancer * 2010 David A. Karnofsky Memorial Award,

American Society of Clinical Oncology The American Society of Clinical Oncology (ASCO) is a professional organization representing physicians of all oncology sub-specialties who care for people with cancer. Founded in 1964 by Fred Ansfield, Harry Bisel, Herman Freckman, Arnoldus G ...

* 2013 Elected fellow of the AACR Academy * 2014 Award of Excellence, Hope Funds for Cancer Research

References

{{DEFAULTSORT:Hoff, Daniel Von American oncologists Fellows of the AACR Academy Living people Columbia University Vagelos College of Physicians and Surgeons alumni Year of birth missing (living people)