DNA-dependent ATPase, abbreviated Dda and also known as Dda helicase and Dda DNA helicase, is the 439- amino acid 49,897- atomic mass unit protein coded by the Dda gene of the

bacteriophage A bacteriophage (), also known informally as a ''phage'' (), is a duplodnaviria virus that infects and replicates within bacteria and archaea. The term was derived from "bacteria" and the Greek φαγεῖν ('), meaning "to devour". Bacteri ...

T4 phage Escherichia virus T4 is a species of bacteriophages that infect ''Escherichia coli'' bacteria. It is a double-stranded DNA virus in the subfamily '' Tevenvirinae'' from the family Myoviridae. T4 is capable of undergoing only a lytic lifecycle ...

, a virus that infects enterobacteria.

Biochemistry

Dda is a molecular motor, specifically a helicase that moves in the 5' end to 3' direction along a

nucleic acid Nucleic acids are biopolymers, macromolecules, essential to all known forms of life. They are composed of nucleotides, which are the monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous base. The two main cl ...

phosphodiester backbone, separating two annealed nucleic acid strands, using the free energy released by the hydrolysis of adenosine triphosphate. The National Center for Biotechnology Information (NCBI) Reference Sequence accession number is NP_049632.

Molecular Biology

Dda is involved in the initiation of T4 DNA replication and DNA recombination.

Genetics

The Dda gene is 31,219

base pair A base pair (bp) is a fundamental unit of double-stranded nucleic acids consisting of two nucleobases bound to each other by hydrogen bonds. They form the building blocks of the DNA double helix and contribute to the folded structure of both DNA ...

long. The GenBank accession number is AAD42555. The coding strand (see also: sense strand) begins in base number 9,410 and ends in base number 10,729.

Cellular Biology

Dda is toxic to cells at elevated levels.

References

External links