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Psychedelic therapy (or psychedelic-assisted therapy) refers to the proposed use of
psychedelic drug Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluc ...
s, such as
psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...
,
ayahuasca AyahuascaPronounced as in the UK and in the US. Also occasionally known in English as ''ayaguasca'' (Spanish-derived), ''aioasca'' (Brazilian Portuguese-derived), or as ''yagé'', pronounced or . Etymologically, all forms but ''yagé'' descen ...
,
LSD Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. I ...
,
psilocin Psilocin, also known as 4-hydroxy-''N'',''N''-dimethyltryptamine (4-HO-DMT), is a substituted tryptamine alkaloid and a serotonergic psychedelic. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocy ...
,
mescaline Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, found ...
(peyote),
DMT Dimethyltryptamine (DMT), also known as ''N'',''N''-dimethyltryptamine (''N'',''N''-DMT), is a serotonergic hallucinogen and investigational drug of the tryptamine family that occurs naturally in many plants and animals, including humans. D ...
,
5-MeO-DMT 5-MeO-DMT (5-methoxy-''N'',''N''-dimethyltryptamine), also known as ''O''-methylbufotenin or mebufotenin (), is a naturally occurring psychedelic of the tryptamine family. It is found in a wide variety of plant species, and is also secreted by ...
,
Ibogaine Ibogaine is a psychoactive indole alkaloid derived from plants such as '' Tabernanthe iboga'', characterized by hallucinogenic and oneirogenic effects. Traditionally used by Central African foragers, it has undergone controversial research ...
,
MDMA 3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (tablet form), and molly (crystal form), is an empathogen–entactogenic drug with stimulant and minor Psychedelic drug, psychedelic properties. In studies, it has been used ...
, to treat
mental disorder A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. A mental disorder is ...
s. As of 2021, psychedelic drugs are controlled substances in most countries and psychedelic therapy is not legally available outside clinical trials, with some exceptions. The procedure for psychedelic therapy differs from that of
therapies A therapy or medical treatment is the attempted remediation of a health problem, usually following a medical diagnosis. Both words, ''treatment'' and ''therapy'', are often abbreviated tx, Tx, or Tx. As a rule, each therapy has indications an ...
using conventional
psychiatric medication A psychiatric or psychotropic medication is a psychoactive drug taken to exert an effect on the chemical makeup of the brain and nervous system. Thus, these medications are used to treat mental illnesses. These medications are typically made of ...
s. While conventional medications are usually taken without supervision at least once daily, in contemporary psychedelic therapy the drug is administered in a single session (or sometimes up to three sessions) in a therapeutic context. The therapeutic team prepares the patient for the experience beforehand and helps them integrate insights from the drug experience afterwards. After ingesting the drug, the patient normally wears eyeshades and listens to music to facilitate focus on the
psychedelic experience A psychedelic experience (known colloquially as a trip) is a temporary altered state of consciousness induced by the consumption of a psychedelic substance (most commonly Lysergic acid diethylamide, LSD, mescaline, psilocybin mushrooms, or N,N- ...
, with the therapeutic team interrupting only to provide reassurance if adverse effects such as anxiety or disorientation arise. As of 2022, the body of high-quality evidence on psychedelic therapy remains relatively small and more, larger studies are needed to reliably show the effectiveness and safety of psychedelic therapy's various forms and applications. On the basis of favorable early results, ongoing research is examining proposed psychedelic therapies for conditions including
major depressive disorder Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive depression (mood), low mood, low self-esteem, and anhedonia, loss of interest or pleasure in normally ...
,
anxiety Anxiety is an emotion characterised by an unpleasant state of inner wikt:turmoil, turmoil and includes feelings of dread over Anticipation, anticipated events. Anxiety is different from fear in that fear is defined as the emotional response ...
and depression linked to
terminal illness Terminal illness or end-stage disease is a disease that cannot be cured or adequately treated and is expected to result in the death of the patient. This term is more commonly used for progressive diseases such as cancer, rather than fatal injur ...
, and
post-traumatic stress disorder Post-traumatic stress disorder (PTSD) is a mental disorder that develops from experiencing a Psychological trauma, traumatic event, such as sexual assault, domestic violence, child abuse, warfare and its associated traumas, natural disaster ...
. The United States
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
has granted "
breakthrough therapy Breakthrough therapy is a United States Food and Drug Administration designation that expedites drug development that was created by Congress under Section 902 of the 9 July 2012 Food and Drug Administration Safety and Innovation Act. The FDA's "b ...
" status, which expedites the potential approval of promising drug therapies, to psychedelic therapies using psilocybin (for treatment-resistant depression and major depressive disorder) and MDMA (for post-traumatic stress disorder).


History


Prehistoric use of psychedelic substances

Humans have long consumed psychedelic substances derived from cacti, seeds, bark, and roots of various plants and fungi. Since ancient times,
shamans Shamanism is a spiritual practice that involves a practitioner (shaman) interacting with the Spirit (supernatural entity), spirit world through Altered state of consciousness, altered states of consciousness, such as trance. The goal of th ...
and
medicine men A medicine man (from Ojibwe ''mashkikiiwinini'') or medicine woman (from Ojibwe ''mashkikiiwininiikwe'') is a traditional healer and spiritual leader who serves a community of Indigenous people of the Americas. Each culture has its own name i ...
have used psychedelics as a way to gain access to the spirit world. Though western culture usually views the practice of shamans and medicine men as predominantly spiritual in nature, elements of psychotherapeutic practice can be read into the entheogenic or shamanic
ritual A ritual is a repeated, structured sequence of actions or behaviors that alters the internal or external state of an individual, group, or environment, regardless of conscious understanding, emotional context, or symbolic meaning. Traditionally ...
s of many
culture Culture ( ) is a concept that encompasses the social behavior, institutions, and Social norm, norms found in human societies, as well as the knowledge, beliefs, arts, laws, Social norm, customs, capabilities, Attitude (psychology), attitudes ...
s.


Research in the mid-20th century

Shortly after
Albert Hofmann Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss chemist known for being the first to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann's team also isolated, named and synthesi ...
discovered the psychoactive properties of LSD in 1943,
Sandoz Laboratories Novartis AG is a Swiss multinational corporation, multinational pharmaceutical company, pharmaceutical corporation based in Basel, Switzerland. Novartis is one of the largest pharmaceutical companies in the world and was the eighth largest by re ...
began widespread distribution of LSD to researchers in 1949. Throughout the 1950s and 1960s, scientists in several countries (e.g., U.S.A.:
Langley Porter Psychiatric Institute Langley Porter Psychiatric Hospital (LPPH) is a psychiatric teaching hospital, part of the Psychiatry Department at the University of California, San Francisco. It was located on the Parnassus campus of UCSF until 2023, when it moved to the UCSF ...
,
MKUltra MKUltra was an illegal human experimentation program designed and undertaken by the U.S. Central Intelligence Agency (CIA) to develop procedures and identify drugs that could be used during interrogations to weaken individuals and force confes ...
) conducted extensive research into experimental
chemotherapeutic Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) in a standard regimen. Chemotherapy may be given with a curat ...
and
psychotherapeutic Psychotherapy (also psychological therapy, talk therapy, or talking therapy) is the use of psychological methods, particularly when based on regular personal interaction, to help a person change behavior, increase happiness, and overcome prob ...
uses of psychedelic drugs. In addition to spawning six international conferences and the release of dozens of books, over 1,000
peer-reviewed Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work ( peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer review ...
clinical papers detailing the use of psychedelic compounds (administered to approximately 40,000 patients) were published by the mid-1960s. Proponents believed that psychedelic drugs facilitated psychoanalytic processes, making them particularly useful for patients with conditions such as
alcoholism Alcoholism is the continued drinking of alcohol despite it causing problems. Some definitions require evidence of dependence and withdrawal. Problematic use of alcohol has been mentioned in the earliest historical records. The World He ...
that are otherwise difficult to treat. However, many of these trials did not meet the methodological standards that are required today. Researchers like
Timothy Leary Timothy Francis Leary (October 22, 1920 – May 31, 1996) was an American psychologist and author known for his strong advocacy of psychedelic drugs. Evaluations of Leary are polarized, ranging from "bold oracle" to "publicity hound". Accordin ...
felt psychedelics could alter the fundamental personality structure or subjective value-system of an individual to great potential benefit. Beginning in 1961, he conducted experiments with prison inmates in an attempt to reduce recidivism with short, intense psychotherapy sessions. Participants were administered psilocybin during these sessions weeks apart with regular group therapy sessions in between. Psychedelic therapy was also applied in a number of other specific patient populations including individuals with
alcoholism Alcoholism is the continued drinking of alcohol despite it causing problems. Some definitions require evidence of dependence and withdrawal. Problematic use of alcohol has been mentioned in the earliest historical records. The World He ...
, children with
autism Autism, also known as autism spectrum disorder (ASD), is a neurodevelopmental disorder characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing d ...
, and persons with
terminal illness Terminal illness or end-stage disease is a disease that cannot be cured or adequately treated and is expected to result in the death of the patient. This term is more commonly used for progressive diseases such as cancer, rather than fatal injur ...
.


Regulation and prohibition in the late 20th century

Throughout the 1960s, concerns raised about the proliferation of unauthorized use of psychedelic drugs by the general public (and, most notably, the
counterculture A counterculture is a culture whose values and norms of behavior differ substantially from those of mainstream society, sometimes diametrically opposed to mainstream cultural mores.Eric Donald Hirsch. ''The Dictionary of Cultural Literacy''. Ho ...
) resulted in the imposition of increasingly severe restrictions on medical and psychiatric research conducted with psychedelic substances. Many countries either banned LSD outright or made it extremely scarce, and, bowing to governmental concerns,
Sandoz Sandoz Group AG is a Swiss company that focuses on generic pharmaceuticals and biosimilars. Prior to October 2023, it was part of a division of Novartis that was established in 2003, when Novartis united all of its generics businesses under the ...
halted production of LSD in 1965. During a congressional hearing in 1966, Senator
Robert F. Kennedy Robert Francis Kennedy (November 20, 1925 – June 6, 1968), also known as RFK, was an American politician and lawyer. He served as the 64th United States attorney general from January 1961 to September 1964, and as a U.S. senator from New Yo ...
questioned the shift of opinion, stating, "Perhaps to some extent we have lost sight of the fact that (LSD) can be very, very helpful in our society if used properly." In 1968, Dahlberg and colleagues published an article in the ''American Journal of Psychiatry'' detailing various forces that had successfully discredited legitimate LSD research. The essay argues that individuals in government and the pharmaceutical industry sabotaged the psychedelic research community by canceling ongoing studies and analysis while labeling genuine scientists as charlatans. Studies on medicinal applications of psychedelics ceased entirely in the United States when the
Controlled Substances Act The Controlled Substances Act (CSA) is the statute establishing federal government of the United States, federal drug policy of the United States, U.S. drug policy under which the manufacture, importation, possession, use, and distribution of ...
was passed in 1970. LSD and many other psychedelics were placed into the most restrictive "Schedule I" category by the
United States Drug Enforcement Administration The Drug Enforcement Administration (DEA) is a Federal law enforcement in the United States, United States federal law enforcement agency under the U.S. Department of Justice tasked with combating illicit Illegal drug trade, drug trafficking a ...
. Schedule I compounds are claimed to possess "a high potential for
abuse Abuse is the act of improper usage or treatment of a person or thing, often to unfairly or improperly gain benefit. Abuse can come in many forms, such as: physical or verbal maltreatment, injury, assault, violation, rape, unjust practices, ...
and the potential to create severe psychological and/or physical dependence" and have "no currently accepted medical use", effectively rendering them illegal to use in the United States for all purposes. Despite objections from the scientific community, authorized research into therapeutic applications of psychedelic drugs had been discontinued worldwide by the 1980s. Despite broad prohibition, unofficial psychedelic research and therapeutic sessions continued nevertheless in the following decades. Some therapists exploited windows of opportunity preceding scheduling of particular psychedelic drugs. Informal psychedelic therapy was conducted clandestinely in underground networks consisting of sessions carried out both by licensed therapists and autodidacts within the community. Due to the largely illegal nature of psychedelic therapy in this period, little information is available concerning the methods that were used. Individuals having published information between 1980 and 2000 regarding psychedelic psychotherapy include George Greer,
Ann Anne, alternatively spelled Ann, is a form of the Latin female name Anna. This in turn is a representation of the Hebrew Hannah, which means 'favour' or 'grace'. Related names include Annie and Ana. Anne is sometimes used as a male name in ...
and
Alexander Shulgin Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American biochemist, broad researcher of synthetic psychoactive compounds, and author of works regarding these, who independently explored the organic chemistry and ph ...
(''
PiHKAL ''PiHKAL: A Chemical Love Story'' is a book by Alexander Shulgin and Ann Shulgin published in 1991. The subject of the work is Psychoactive drug, psychoactive phenethylamine Derivative (chemistry), chemical derivatives, notably those that act ...
'' and ''
TiHKAL ''TiHKAL: The Continuation'' is a 1997 book written by Alexander Shulgin and Ann Shulgin about a family of psychoactive drugs known as tryptamines. A sequel to '' PiHKAL: A Chemical Love Story'', ''TiHKAL'' is an acronym that stands for "Trypt ...
''),
Myron Stolaroff Myron J. Stolaroff (August 20, 1920 – January 6, 2013) was an author and researcher who is best known for his studies involving psychedelic psychotherapy. He also conducted clinical studies that attempted to measure the effects of LSD, mescalin ...
(''The Secret Chief'', regarding the underground therapy done by Leo Zeff), and Athanasios Kafkalides.


Resurgence in the early 21st century

In the early 2000s, a renewal of interest in the
psychiatric Psychiatry is the medical specialty devoted to the diagnosis, treatment, and prevention of deleterious mental conditions. These include matters related to cognition, perceptions, mood, emotion, and behavior. Initial psychiatric assessment of ...
use of
psychedelics Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluci ...
contributed to an increase in clinical research centering on the
psychopharmacological Psychopharmacology (from Greek ; ; and ) is the scientific study of the effects drugs have on mood, sensation, thinking, behavior, judgment and evaluation, and memory. It is distinguished from neuropsychopharmacology, which emphasizes the corre ...
effects of these drugs and their subsequent applications. Advances in science and technology allowed researchers to collect and interpret extensive data from animal studies, and the advent of new technologies such as
PET A pet, or companion animal, is an animal kept primarily for a person's company or entertainment rather than as a working animal, livestock, or a laboratory animal. Popular pets are often considered to have attractive/ cute appearances, inte ...
and
MRI Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to generate pictures of the anatomy and the physiological processes inside the body. MRI scanners use strong magnetic fields, magnetic field gradients, and rad ...
scanning made it possible to examine the sites of action of hallucinogens in the brain. Furthermore, retrospective studies involving users of illicit drugs as voluntary subjects were conducted, allowing data to be collected on how psychedelics affect the human brain while simultaneously sidestepping bureaucratic difficulties associated with providing illegal substances to subjects. The new century also ushered in a broader change in political attitude towards psychedelic medicine—specifically within the
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
.
Curtis Wright Curtis Blaine Wright (born June 6, 1955) is an American country music artist. He first played in the 1970s and 80s as a member of the Super Grit Cowboy Band before becoming a solo artist in the late 1980s and early 1990s. Wright charted three s ...
, then deputy director of the FDA Division of Anesthetic, Critical Care and Addiction Drugs explained a motivation for this change: "the agency was challenged legally in a number of cases and also underwent a process of introspection, asking 'Is it proper to treat this class of drugs differently?'" As of 2014, global treaties listing LSD and psilocybin as "Schedule I" controlled substances continues to inhibit a better understanding of these drugs. Much of the renewed clinical research has been conducted with
psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...
and
MDMA 3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (tablet form), and molly (crystal form), is an empathogen–entactogenic drug with stimulant and minor Psychedelic drug, psychedelic properties. In studies, it has been used ...
in the United States with special permission and
breakthrough therapy Breakthrough therapy is a United States Food and Drug Administration designation that expedites drug development that was created by Congress under Section 902 of the 9 July 2012 Food and Drug Administration Safety and Innovation Act. The FDA's "b ...
designations by the
FDA The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...
, while other studies have investigated the mechanisms and effects of
ayahuasca AyahuascaPronounced as in the UK and in the US. Also occasionally known in English as ''ayaguasca'' (Spanish-derived), ''aioasca'' (Brazilian Portuguese-derived), or as ''yagé'', pronounced or . Etymologically, all forms but ''yagé'' descen ...
and
LSD Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. I ...
. MDMA-assisted psychotherapy is being actively researched by
MAPS A map is a symbolic depiction of interrelationships, commonly spatial, between things within a space. A map may be annotated with text and graphics. Like any graphic, a map may be fixed to paper or other durable media, or may be displayed on ...
. As of 2023, many new centers for psychedelics research have been launched, including the Centre for Psychedelic Research at
Imperial College London Imperial College London, also known as Imperial, is a Public university, public research university in London, England. Its history began with Prince Albert of Saxe-Coburg and Gotha, Prince Albert, husband of Queen Victoria, who envisioned a Al ...
, the UC Berkeley Center for the Science of Psychedelics, the Center for Psychedelic and Consciousness Research at
Johns Hopkins University The Johns Hopkins University (often abbreviated as Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland, United States. Founded in 1876 based on the European research institution model, J ...
, the Center for Psychedelic Research and Therapy at
Dell Medical School The Dell Medical School is the graduate medical school of the University of Texas at Austin in Austin, Texas. The school opened to the inaugural class of 50 students in the summer of 2016 as the newest of 18 colleges and schools on the UT Austin ...
at the University of Texas at
Austin Austin refers to: Common meanings * Austin, Texas, United States, a city * Austin (given name), a list of people and fictional characters * Austin (surname), a list of people and fictional characters * Austin Motor Company, a British car manufac ...
, the Center for Psychedelic Psychotherapy and Trauma Research at the
Icahn School of Medicine at Mount Sinai The Icahn School of Medicine at Mount Sinai (ISMMS or Mount Sinai), formerly the Mount Sinai School of Medicine, is a private medical school in New York City, New York, United States. The school is the academic teaching arm of the Mount Sina ...
, the Psychae Institute in
Melbourne Melbourne ( , ; Boonwurrung language, Boonwurrung/ or ) is the List of Australian capital cities, capital and List of cities in Australia by population, most populous city of the States and territories of Australia, Australian state of Victori ...
, and the Naut sa mawt Center for Psychedelic Research at
Vancouver Island University Vancouver Island University (abbreviated as VIU, formerly known as Malaspina University-College and Malaspina College) is a Canadian public research university serving Vancouver Island and coastal British Columbia. Malaspina College opened in 196 ...
. Harvard will create a Study of Psychedelics in Society and Culture. A survey published in 2023 found strong support for psychedelic therapy among psychiatrists in the United States, revealing a significant positive shift in attitudes toward this treatment modality in comparison to a previous survey published in 2018. More than half of psychiatrists in the 2023 study expressed intentions to incorporate psychedelic therapy into their practice if regulatory approval is granted. In
Australia Australia, officially the Commonwealth of Australia, is a country comprising mainland Australia, the mainland of the Australia (continent), Australian continent, the island of Tasmania and list of islands of Australia, numerous smaller isl ...
, authorised psychiatrists can prescribe psilocybin for treatment-resistant depression, and MDMA for post-traumatic stress disorder. In 2024, an FDA advisory panel voted against approving MDMA-assisted therapy for PTSD, "raising questions about the credibility of the research being conducted and the safety of those involved in the trials". The FDA advisors voted 9-2 that the available data didn’t show MDMA was effective in treating PTSD, and 10-1 that the benefits of MDMA-assisted therapy did not outweigh the risks. However, the U.S. Department of Veterans Affairs has since committed $1.5 million to its first study on psychedelic-assisted therapy for PTSD and alcohol use disorder in veterans, signaling growing institutional interest despite FDA skepticism. In addition, veteran-led nonprofits like the Heroic Hearts Project are working with researchers to expand access to psychedelic therapies for military personnel and veterans. In 2025, PsychedeliCare launched a European Citizens’ Initiative aiming to enable the implementation of psychedelic-assisted therapies in the EU to ensure safe and affordable psychedelic-assisted therapies.


Applications

Psychedelic substances which may have therapeutic uses include
psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...
(the main active compound found in "magic" mushrooms),
mescaline Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, found ...
(the main active compound in the peyote cactus), and
LSD Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. I ...
. Although the history behind these substances has hindered research into their potential medicinal value, scientists are now able to conduct studies and renew research that was halted in the 1970s. Some research has shown that these substances have helped people with such mental disorders as obsessive-compulsive disorder,
post-traumatic stress disorder Post-traumatic stress disorder (PTSD) is a mental disorder that develops from experiencing a Psychological trauma, traumatic event, such as sexual assault, domestic violence, child abuse, warfare and its associated traumas, natural disaster ...
,
alcoholism Alcoholism is the continued drinking of alcohol despite it causing problems. Some definitions require evidence of dependence and withdrawal. Problematic use of alcohol has been mentioned in the earliest historical records. The World He ...
, depression, and
cluster headaches Cluster headache is a neurological disorder characterized by recurrent severe headaches on one side of the head, typically around the eye(s). There is often accompanying eye watering, nasal congestion, or swelling around the eye on the affecte ...
. Some of the well known particular psychedelic substances that have been used to this day are:
LSD Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. I ...
,
DMT Dimethyltryptamine (DMT), also known as ''N'',''N''-dimethyltryptamine (''N'',''N''-DMT), is a serotonergic hallucinogen and investigational drug of the tryptamine family that occurs naturally in many plants and animals, including humans. D ...
,
psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...
,
mescaline Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, found ...
,
2C-B 2C-B, also known as 4-bromo-2,5-dimethoxyphenethylamine or by the slang name Nexus, is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug. It was first synthesized by Alexander Shulgin in 1974 for use in psychoth ...
,
2C-I 2C-I, also known as 2,5-dimethoxy-4-iodophenethylamine, is a phenethylamine of the 2C family with psychedelic effects. It was first synthesized by Alexander Shulgin, and is described in Shulgin's book ''PiHKAL'' (1991). The substance is con ...
,
5-MeO-DMT 5-MeO-DMT (5-methoxy-''N'',''N''-dimethyltryptamine), also known as ''O''-methylbufotenin or mebufotenin (), is a naturally occurring psychedelic of the tryptamine family. It is found in a wide variety of plant species, and is also secreted by ...
, AMT,
ibogaine Ibogaine is a psychoactive indole alkaloid derived from plants such as '' Tabernanthe iboga'', characterized by hallucinogenic and oneirogenic effects. Traditionally used by Central African foragers, it has undergone controversial research ...
, and DOM. In general, the mechanism of action of how these drugs have therapeutic effects is poorly understood. Their effects are strongly dependent on the environment in which they are given and on the recipient's state of mind (
set and setting Set and setting, when referring to a psychedelic drug experience or the use of other psychoactive substances, means one's mindset (shortened to "set") and the physical and social environment (the "setting") in which the user has the experience ...
).


In substance use disorders

Studies by
Humphry Osmond Humphry Fortescue Osmond (1 July 1917 – 6 February 2004) was an English psychiatrist who moved to Canada and later the United States. He is known for inventing the word '' psychedelic'' and for his research into interesting and useful applicat ...
, Betty Eisner, and others examined the possibility that psychedelic therapy could treat
alcoholism Alcoholism is the continued drinking of alcohol despite it causing problems. Some definitions require evidence of dependence and withdrawal. Problematic use of alcohol has been mentioned in the earliest historical records. The World He ...
(or, less commonly, other addictions).
Bill Wilson William Griffith Wilson (November 26, 1895 – January 24, 1971), also known as Bill Wilson or Bill W., was an American businessman who conceived and co-founded Alcoholics Anonymous (AA), with fellow co-founder Bob Smith. AA is an internation ...
, the founder of Alcoholics Anonymous, used
LSD Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. I ...
during supervised experiments with Betty Eisner,
Gerald Heard Henry FitzGerald Heard (6 October 1889 – 14 August 1971), commonly called Gerald Heard, was an English-born American historian, science writer and broadcaster, public lecturer, educator, and philosopher. He wrote many articles and over 35 boo ...
, and
Aldous Huxley Aldous Leonard Huxley ( ; 26 July 1894 – 22 November 1963) was an English writer and philosopher. His bibliography spans nearly 50 books, including non-fiction novel, non-fiction works, as well as essays, narratives, and poems. Born into the ...
. He ingested LSD for the first time on August 29, 1956. With Wilson's invitation, his wife Lois, his spiritual adviser Father Ed Dowling, and Nell Wing also participated in experimentation of this drug. Later Wilson wrote to
Carl Jung Carl Gustav Jung ( ; ; 26 July 1875 – 6 June 1961) was a Swiss psychiatrist, psychotherapist, and psychologist who founded the school of analytical psychology. A prolific author of Carl Jung publications, over 20 books, illustrator, and corr ...
, praising the results and recommending it as validation of Jung's spiritual experience. According to Wilson, the session allowed him to re-experience a spontaneous spiritual experience he had had years before, which had enabled him to overcome his own alcoholism. A 1998 review of the effectiveness of psychedelic therapy for treating alcoholism concluded that due to methodological difficulties in the research prior to that time, it was not possible to state whether it was effective. A 2012
meta-analysis Meta-analysis is a method of synthesis of quantitative data from multiple independent studies addressing a common research question. An important part of this method involves computing a combined effect size across all of the studies. As such, th ...
found that "In a pooled analysis of six randomized controlled clinical trials, a single dose of LSD had a significant beneficial effect on alcohol misuse at the first reported follow-up assessment, which ranged from 1 to 12 months after discharge from each treatment program. This treatment effect from LSD on alcohol misuse was also seen at 2 to 3 months and at 6 months, but was not statistically significant at 12 months post-treatment. Among the three trials that reported total abstinence from alcohol use, there was also a significant beneficial effect of LSD at the first reported follow-up, which ranged from 1 to 3 months after discharge from each treatment program." In 2022 a systematic review was published on the efficacy of ibogaine/noribogaine, an indole alkaloid with “anti-addictive” properties, to treat substance use disorders looking at studies up to December 2020. Oral ingestion of ibogaine leads to an intense psychedelic experience with effects lasting up to 72 hours that lead participants to insights that may change the way they view life and their ways of thinking; however, the mechanism of how this drug works to reduce substance use is not yet understood. Evidence suggests that ibogaine does have some reduction on opioid and cocaine misuse, but more well designed, larger randomly controlled trials are required to fully understand the therapeutic benefits. Significant adverse reactions were experienced by participants including cardiotoxicity, QT prolongation, ataxia, psychosis, and several fatalities were reported due to toxic adverse events. Analysis of the fatalities concluded that patients with cardiac comorbidities and that those that are taking concurrent medications are at higher risk of a medical emergency. A systematic review completed in 2023, containing studies from the past decade, looked at the ability of psychedelic therapy in combination with psychotherapy to help reduce substance use, cravings, and abstinence of addictions including alcohol, cocaine, opioids, and nicotine. Studies commonly reported reductions in substance misuse, however, the quality of evidence is too low to draw solid conclusions on the efficacy of psychedelic treatments for
substance use disorder Substance use disorder (SUD) is the persistent use of drugs despite substantial harm and adverse consequences to self and others. Related terms include ''substance use problems'' and ''problematic drug or alcohol use''. Along with substance-ind ...
s. However, a systematic review of human and animal studies showed that a single dose of LSD for treatment of AUD led to greater odds of improvement in alcohol consumption than control participants.


In terminal illness

During the early 1950s and 1960s the National Institute of Mental Health sponsored the study of psychedelic drugs such as psilocybin and LSD to alleviate the debilitating anxiety and depression patients with terminal diagnoses may feel. While these early studies are hard to find, the resurgence of interest in psychedelic drugs to treat humans end of life mindset has led to some small studies in the 21st century. The more recently published research strengthens the findings from the 1950s and 1960s showing the drug is extremely effective in reducing anxiety and depression in this patient population once carefully screened and has few adverse effects when administered in a psychotherapy setting and under medical supervision. The psychologists leading psychedelic drug therapy trials found that end of life patients often experience the emotional turmoil of dying more than the physical aspects. This mindset makes it difficult for patients to find meaning and enjoyment in life during their last few months or years. While all patients have completely different experiences on these mind altering drugs the research subjects interviewed all expressed they had, "heightened clarity and confidence about their personal values and priorities, and a renewed or enhanced recognition of intrinsic meaning and value of life." More recently, researchers have argued that psychedelic therapy is beneficial for these patients because it may specifically reduce their fear of dying. As of 2016, Johns Hopkins University and New York University have conducted large randomized, placebo-controlled studies. These two studies are some of the first large controlled studies measuring the effects of psychedelic therapy on depression and anxiety in cancer patients. Across clinician-ratings and self-ratings, the psychedelic treatment produced statistically significant lowered anxiety and depression, with sustenance for at least 6 months. The studies monitored for adverse effects from the drugs but no serious adverse effects were observed. Both studies also attributed the efficacy in part to patients experiencing a "mystical experience". A mystical experience is a very personal introspective experience where some sort of unity or transcendence of time and space is described. More research is necessary to expand generalizability of the conclusions. Also, more research is necessary to understand the biological properties of a mystical experience. Evidence is growing for the use of atypical psychedelics such as ketamine for treating depression in terminally ill patients, with repeated IV administration having the most therapeutic effect. These studies did not have any patients experience any serious adverse effects; however, ketamine-induced ulcerative cystitis is a concern for repeated long-term administration. Qualitative studies are required to better understand the mechanism and thought process changes that lead to therapeutic outcomes.


In post-traumatic stress disorder (PTSD)

The
Multidisciplinary Association for Psychedelic Studies The Multidisciplinary Association for Psychedelic Studies (MAPS) is an American nonprofit organization working to raise awareness and understanding of psychedelic substances. MAPS was founded in 1986 by Rick Doblin and is now based in San Jose, C ...
(MAPS) is conducting studies in the psychedelic treatment of post-traumatic stress disorder. The
Phase 2 Michael Lawrence Marrow (August 2, 1955 – December 12, 2019), known as PHASE 2 and Lonny Wood, was an American aerosol paint artist based in New York City. Mostly active in the 1970s, Phase 2 is generally credited with originating the "bubble ...
trials of these studies, conducted in the U.S., Canada, and Israel, consisted of 107 participants who had chronic, treatment-resistant PTSD, and had had PTSD for an average of 17.8 years. Out of the 107 participants, 61% no longer qualified for PTSD after three sessions of MDMA-assisted psychotherapy two months after the treatment. At the 12-month follow-up session, 68% no longer had PTSD. Phase 2 trials conducted between 2004 and 2010 reported an overall remission rate of 66.2% and low rates of adverse effects for subjects with chronic PTSD. In 2017, MAPS and the FDA reached an agreement on the special protocol for phase 3 trials. Evidence shows that MDMA-assisted psychotherapy versus control shows clinically significant improvement in Clinician-Administered PTSD Scale (CAPS) scores from baseline, with most of the patients no longer meeting the CAPS score for PTSD. Effects of MDMA-assisted psychotherapy can be observed up to 12 months after receiving 2-3 active sessions of moderate to high dose MDMA (75–125 mg). It is important to note that given the difficulties with appropriate blinding in trials of MDMA- and psychedelic-assisted psychotherapy the results are likely overestimated. Furthermore, there are no superiority or non-inferiority clinical trials comparing MDMA-assisted psychotherapy to already existent evidence-based treatments for PTSD, but given the effects reported in clinical trials of MDMA-assisted psychotherapy for PTSD there is no reason to believe that this treatment modality is more effective than existent trauma-focused psychological treatments. In 2024, an FDA advisory panel voted against approving MDMA-assisted therapy for PTSD, "raising questions about the credibility of the research being conducted and the safety of those involved in the trials". The FDA advisors voted 9-2 that the available data didn’t show MDMA was effective in treating PTSD, and 10-1 that the benefits of MDMA-assisted therapy did not outweigh the risks. However, the U.S. Department of Veterans Affairs has since committed $1.5 million to its first study on psychedelic-assisted therapy for PTSD and alcohol use disorder in veterans, signaling growing institutional interest despite FDA skepticism. In addition, veteran-led nonprofits like the Heroic Hearts Project are working with researchers to expand access to psychedelic therapies for military personnel and veterans.


In depressive and anxiety disorders

In 2019, the FDA approved the use of
esketamine Esketamine, sold under the brand names Spravato (for depression (mood), depression) and Ketanest (for anesthesia) among others, is the ''S''(+) enantiomer of ketamine. It is a dissociative hallucinogen drug used as a general anesthetic and as ...
for intranasal use for major depressive disorder (MDD) and treatment-resistant depression (TRD), in conjunction with an oral antidepressant. Also in 2019, the FDA granted "
breakthrough therapy Breakthrough therapy is a United States Food and Drug Administration designation that expedites drug development that was created by Congress under Section 902 of the 9 July 2012 Food and Drug Administration Safety and Innovation Act. The FDA's "b ...
" status to psilocybin for treatment-resistant depression and major depressive disorder in order to hasten the process for potential regulatory approval. The designation of "breakthrough therapy" fast-tracks the study of drugs where preliminary clinical evidence shows that they could be substantially more effective than therapies that are already available. Studies on the clinical effects of ayahuasca have found significant antidepressant and anxiety-reducing effects, leading to calls for further research to overcome methodological limitations in the existing studies. There is some evidence that psilocybin in combination with
MDMA 3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (tablet form), and molly (crystal form), is an empathogen–entactogenic drug with stimulant and minor Psychedelic drug, psychedelic properties. In studies, it has been used ...
could be helpful for treating psychiatric disorders, but only when administered in a controlled clinical setting. There is limited evidence that reductions in suicidality scores can be observed immediately after administration of ayahuasca or psilocybin, observable up to 6 months after administration.


In Obsessive Compulsive Disorder (OCD)

Since 1964, multiple case studies with
psychedelic drugs Psychedelics are a subclass of Hallucinogen, hallucinogenic drugs whose primary effect is to trigger psychoactive drug, non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also ...
have been performed in patients with either diagnosed OCD or patients exhibiting obsessive and/or compulsive symptoms. In 1964 and 1977, two case studies were published that showed a reduction in symptoms of patients who had previously exhibited obsessive and/or compulsive behaviors after taking ''Psilocybe'' mushrooms. In addition, three studies from 1987 to 1997 reported reductions in obsessive and/or compulsive symptoms in patients with diagnosed OCD after taking
LSD Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. I ...
and
psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...
. In 2014 and 2021, two case studies published by researchers from Arizona and Mexico, respectively, explained how patients taking 2 grams of psilocybin every 2-3 weeks not only saw qualitative improvements in their OCD symptoms, but also sustained this symptom improvement for several weeks after each dose. In 2024, a systematic review was published analyzing the possible therapeutic benefits of psychedelics on OCD and related disorders. Findings include that LSD may be less tolerable than psilocybin due to more potential exacerbations of anxiety and OCD symptoms. Case reports found that psilocybin must be given in repeated doses in order to maintain reduction in OCD symptoms, which differentiates from its effect on depression. In patients diagnosed with
body dysmorphic disorder Body dysmorphic disorder (BDD), also known in some contexts as dysmorphophobia, is a mental disorder defined by an overwhelming preoccupation with a perceived flaw in one's physical appearance. In BDD's delusional variant, the flaw is imagined ...
and OCD, a single dose of psilocybin given for OCD symptoms was found to increase insight into the patient's disease, resulting in these patients seeking mental health treatment and recognizing that more effort was needed to tolerate their obsessions and resist their compulsions. This is important because among individuals with OCD, poor insight into their condition is associated with a worse
prognosis Prognosis ( Greek: πρόγνωσις "fore-knowing, foreseeing"; : prognoses) is a medical term for predicting the likelihood or expected development of a disease, including whether the signs and symptoms will improve or worsen (and how quickly) ...
. Because of existing research showing the efficacy of
Exposure and Response Prevention Exposure therapy is a technique in behavior therapy to treat anxiety disorders. Exposure therapy involves exposing the patient to the anxiety source or its context (without the intention to cause any danger). Doing so is thought to help them overc ...
(ERP) in
psychiatric disorders A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. A mental disorder is ...
, future studies may seek to combine psychedelic therapy, specifically with
psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...
, with ERP as an adjunct for symptom remission, although no such studies have yet been conducted.


In reducing criminal behavior

In 2017, researchers mainly from the
University of Birmingham The University of Birmingham (informally Birmingham University) is a Public university, public research university in Birmingham, England. It received its royal charter in 1900 as a successor to Queen's College, Birmingham (founded in 1825 as ...
published research suggesting that psilocybin use is correlated with reduced criminal behavior. The researchers analyzed data from 480,000 U.S. adults collected by the National Survey on Drug Use and Health on their past use of psychedelics, including ayahuasca, dimethyltryptamine, LSD, mescaline, peyote, San Pedro, and psilocybin mushrooms. While other illicit drugs have been associated with increased criminal behavior, the researchers found that psychedelic substances were instead associated with reduced criminal behavior. Usage of these substances was associated with a 12% reduction in likelihood of assault, 18% reduction in likelihood of other violent crimes, 27% reduction in likelihood of committing larceny and theft, and 22% reduction in likelihood of committing other property crimes. These findings potentially support the use of psychedelic therapy in forensic and clinical settings. In a prior 2014 study, researchers explored the relationship between recidivism and naturalistic hallucinogens in criminal justice populations with a history of substance use. The results concluded that hallucinogens promoted prosocial behaviors in a population which is typically associated with high recidivism rates. The usage of hallucinogens has been found to reduce supervision failure in ex-convicts. This inherently encourages drug abstinence, including the use of alcohol, resulting in lower rates of recidivism. A 2018 study found that men who had used psychedelic drugs in the past were less likely to commit violence against their current partners compared to those who had not used these substances. The study suggests that the use of psychedelic drugs in men might be associated with a reduced likelihood of committing violence against intimate partners, potentially due to improved emotion regulation. A 2022 U.S. study found that use of classic psychedelics was associated with lowered odds of criminal arrest. The research suggests that 7 of the 11 arrest variables were reduced with lifetime psilocybin use. Peyote use was found to reduce the odds of
driving under the influence Driving under the influence (DUI) is the crime of driving, operating, or being in control of a vehicle while one is impaired from doing so safely by the effect of either alcohol (drug), alcohol (see drunk driving) or some other drug, whether re ...
and vehicle theft. Lastly, mescaline use was found to reduce drug possession/sale. No other substances shared a positive relationship with reducing criminal behavior.


Contraindications

Psychedelic therapy is
contraindicated In medicine, a contraindication is a condition (a situation or factor) that serves as a reason not to take a certain medical treatment due to the harm that it would cause the patient. Contraindication is the opposite of indication, which is a rea ...
for people who: * are pregnant, * have a history of epilepsy/other seizure disorder, * have severe cardiovascular disease including uncontrolled blood pressure, heart failure, coronary artery disease, or previous heart attack or stroke, * use medications like
SSRI Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs primarily work by ...
or MAO-I antidepressants, * have a personal or family history of primary psychotic or affective disorders like
schizophrenia Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, f ...
,
schizoaffective disorder Schizoaffective disorder is a mental disorder characterized by symptoms of both schizophrenia (psychosis) and a mood disorder, either bipolar disorder or depression. The main diagnostic criterion is the presence of psychotic symptoms for at leas ...
,
Bipolar I disorder Bipolar I disorder (BD-I; pronounced "type one bipolar disorder") is a type of bipolar spectrum disorder characterized by the occurrence of at least one manic episode, with or without mixed or psychotic features. Most people also, at other ti ...
, or psychotic symptoms in the setting of depression.


Criticisms and controversies

Although psychedelic therapy has shown promise in treating a range of mental health conditions—including depression, PTSD, and substance use disorders—it has also generated significant debate across ethical, cultural, and scientific domains. Critics have raised concerns about the overenthusiastic framing of psychedelics as a universal or revolutionary solution, cautioning that such narratives may overshadow limitations in clinical evidence, long-term safety data, and equity in access. Others argue that the rapid commercialization and medicalization of psychedelics risks reproducing existing structural inequalities in mental health care. In response, scholars have called for a more cautious, interdisciplinary approach that considers social context, informed consent, community frameworks, and culturally responsive practices.


Ethical and safety concerns

Critics have raised significant concerns regarding the ethical implications of psychedelic-assisted therapies, particularly focusing on the challenges surrounding informed consent and patient safety. The inherently unpredictable and often ineffable nature of psychedelic experiences can make it difficult for patients to fully comprehend and anticipate potential psychological risks. These challenges complicate the process of obtaining fully informed consent, especially in therapeutic contexts where long-term monitoring or integration support may be limited. In August 2024, the U.S. Food and Drug Administration (FDA) declined to approve the first MDMA-based treatment for post-traumatic stress disorder (PTSD), citing insufficient data and concerns about trial methodology. The agency highlighted issues such as a "striking lack" of documentation regarding participants' prior substance use, problems with trial design, and the necessity for more robust evidence. The FDA requested an additional late-stage trial to further assess the drug's safety and efficacy. Further ethical concerns have emerged from reports of misconduct within clinical trials. For instance, in August 2024, three papers on MDMA-assisted psychotherapy for PTSD were retracted from the journal *Psychopharmacology* due to ethical violations. These included inappropriate physical contact between a trial participant and an unlicensed therapist, leading to an unethical sexual relationship and alleged sexual assault. The data from this site were not removed from the analyses, raising questions about the integrity of the research. The potential for therapist misconduct is a significant safety concern in psychedelic-assisted therapy. The altered states of consciousness induced by psychedelics can increase patients' suggestibility and vulnerability, necessitating rigorous ethical standards and oversight. Ensuring patient safety requires comprehensive training for therapists, strict adherence to ethical guidelines, and robust mechanisms for reporting and addressing any instances of misconduct. Addressing these ethical and safety concerns is crucial for the responsible development and implementation of psychedelic-assisted therapies. This includes establishing clear protocols for informed consent, ensuring transparency in clinical trial methodologies, implementing stringent ethical standards for therapists, and conducting thorough long-term follow-up studies to monitor patient outcomes.


Methodological and structural limitations

Psychedelic clinical trials have faced recurring criticism for methodological shortcomings, particularly small sample sizes, short follow-up durations, and the exclusion of participants with comorbid or severe psychiatric conditions. These constraints reduce the external validity of findings, limiting their applicability to broader, real-world populations. For instance, many studies prioritize controlled environments and relatively healthy participants, thereby excluding those who may be most in need of innovative mental health treatments, such as individuals with trauma histories, substance use disorders, or severe depression. In addition to these design limitations, demographic homogeneity remains a persistent issue in psychedelic research. A review of 18 psychedelic clinical trials found that 82.3% of participants were non-Hispanic White, with minimal inclusion of Black, Latino, Indigenous, and Asian individuals. More recent analyses suggest that despite growing interest in equitable access, racial and ethnic minorities remain significantly underrepresented in both research studies and clinical practice settings. This underrepresentation has sparked broader concerns about systemic exclusion and the equitable distribution of therapeutic benefits. Historical medical abuses—such as the Tuskegee Syphilis Study and CIA-led MK-Ultra experiments—have contributed to deep mistrust in research institutions among marginalized communities. To address these disparities, scholars and clinicians have called for more inclusive and culturally responsive research practices. Proposed strategies include partnering with community organizations, diversifying research staff, and creating protocols that respect cultural traditions and concerns. Such efforts aim not only to expand access but also to rebuild trust and ensure that psychedelic-assisted therapies are effective and ethical across diverse populations.


Sociological critiques and inequality in access and outcomes

Although psychedelic therapy is often presented as a universally beneficial mental health intervention, emerging sociological and epidemiological research has identified disparities in outcomes across demographic groups. Studies suggest that benefits associated with psychedelic use may be unequally distributed due to structural and social inequalities. Several peer-reviewed studies have documented that racial and ethnic minorities often experience diminished psychological benefits from psychedelics compared to White participants, even when controlling for socioeconomic status, education, and baseline health. Additional research focusing on American Indian Areas has linked geographic and historical disadvantage to more limited mental health improvements following psychedelic use. Gender differences have also been observed. Findings indicate that women may experience more variable or attenuated outcomes than men, particularly in relation to stigma reduction and distress. Other research suggests that education moderates these gender differences, with highly educated men reporting the strongest positive effects. Disparities based on marital and employment status have also been explored. Individuals who are married or employed report greater psychological benefit, potentially due to social support systems and improved access to post-experience integration resources. Variation has been noted in outcomes by religious affiliation and participation. Some studies suggest that individuals with strong religious integration may experience more meaningful or sustained benefits due to the availability of social and interpretive frameworks, while others with rigid or punitive religious backgrounds may experience conflict or distress. LGBTQ+ individuals have also been found to experience unique patterns of benefit and risk in relation to psychedelic use. While some research documents substantial mental health improvements, others point to amplified vulnerability due to minority stress or inadequate therapeutic frameworks. In addition, findings suggest that those from historically marginalized populations are more likely to avoid formal healthcare following psychedelic use due to prior stigma or systemic exclusion, potentially increasing risk or reducing access to integration services. Collectively, this growing body of research challenges assumptions of universal benefit and has contributed to calls for equity-centered approaches in psychedelic science. These include greater attention to structural context, culturally responsive practices, and the inclusion of diverse communities in both research and therapeutic design.


Overmedicalization and commercialization


Marginalization of traditional and community-based healing

Scholars and activists have raised concerns that the medicalization of psychedelics risks marginalizing longstanding traditional, spiritual, and community-based approaches to healing using psychedelics. Tightly regulated clinical models—especially those requiring physician oversight and FDA approval—often exclude practices rooted in Indigenous knowledge, harm-reduction communities, or informal peer support structures. Critics argue that this narrowing of acceptable use may replicate colonial dynamics by privileging biomedical authority while disregarding alternative cultural and historical frameworks for psychedelic use. Some researchers note that medical gatekeeping can deter vulnerable populations—especially those with prior trauma or medical mistrust—from seeking care. Others argue that community-first models, such as peer-led integration circles or underground networks, have demonstrated safety and efficacy outside of formal institutions but remain unrecognized in dominant medical discourse. These concerns have fueled calls for pluralistic frameworks that allow coexistence between clinical models and culturally grounded or community-led approaches to psychedelic healing.


Organizational influence and conflicts of interest

The influence of prominent organizations and individuals in the psychedelic field has raised concerns about transparency, accountability, and potential conflicts of interest. The Multidisciplinary Association for Psychedelic Studies (MAPS), a leading organization in psychedelic research and advocacy, has faced scrutiny regarding its internal governance and handling of ethical violations. In 2019, MAPS publicly disclosed that former clinical sub-investigators in a sponsored trial had violated ethical standards during therapy sessions. While MAPS stated that it responded promptly and transparently, critics questioned the adequacy of the organization's oversight mechanisms. Further concerns emerged from the 2023 Psychedelic Science conference in Denver, Colorado, hosted by MAPS and the Multidisciplinary Association for Psychedelic Studies Public Benefit Corporation (MAPS PBC). The conference featured over 300 speakers, including academic researchers, therapists, entrepreneurs, and policy advocates. Many speakers disclosed financial interests in psychedelic companies, intellectual property claims, or affiliations with private clinics. Notable figures with such disclosures included: * Robin Carhart-Harris, a leading neuroscientist in psychedelic research * Bia Labate, an anthropologist and executive director of the Chacruna Institute * Rick Doblin, founder and president of MAPS * Tim Ferriss, author and investor * Charles Raison, psychiatrist and director of the Center for Compassion Studies at the University of Arizona * Matthew Johnson, professor of psychiatry and behavioral sciences at Johns Hopkins University These conflict of interest disclosures were initially made available through the conference’s mobile app by the Postgraduate Institute for Medicine (PIM) but were later removed. Psymposia, a nonprofit media organization, archived the full list to preserve public access and transparency. Rick Doblin has faced criticism for his dual role as both an advocate and the head of an organization poised to benefit financially from the potential FDA approval of MDMA-assisted therapy. Observers argue that this overlap between activism, research, and commercial interest may compromise objectivity in public discourse and trial reporting. Broader concerns have been raised about how financial entanglements could influence research agendas and regulatory frameworks. In 2024, the Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics at Harvard Law School hosted a panel titled “Disclosed: Conflicts of Interest in the Psychedelics Ecosystem,” which examined how investment structures, private equity, and market speculation are shaping the future of psychedelic medicine. These developments have led to calls for independent oversight, greater funding transparency, and more inclusive governance models to protect the integrity of psychedelic science and practice.


Patents, venture capital, and market consolidation

As the psychedelic field attracts increasing financial interest, critics have raised alarms about the ethical and structural implications of venture capital investment, aggressive patent strategies, and the potential monopolization of psychedelic therapies. A number of biotechnology companies and investors have moved quickly to patent not only psychedelic compounds—such as psilocybin analogs and synthetic DMT—but also delivery methods, treatment protocols, and even aspects of the therapeutic experience itself. This surge of intellectual property claims has sparked debates over the ethics of commodifying substances that have deep cultural, communal, and spiritual significance. Some researchers and Indigenous advocates argue that patenting naturally occurring substances or ceremonial knowledge represents a form of "biopiracy," in which Western institutions extract and profit from traditional practices without community consent or benefit-sharing mechanisms. The controversy has intensified as corporations such as COMPASS Pathways and MindMed have secured patents on specific synthetic formulations or therapy session structures, prompting concerns about limited access, market exclusivity, and the suppression of innovation. In parallel, the influx of venture capital has raised questions about whether financial incentives may undermine patient well-being. Observers note that the pressure to deliver returns to shareholders could lead to expedited clinical trials, underreporting of adverse effects, or the commercialization of unproven therapies. These dynamics are increasingly seen as misaligned with the values of many early psychedelic researchers, who viewed the field as an opportunity to promote personal transformation, healing, and societal reflection rather than profit maximization. To mitigate these risks, scholars and advocacy groups have called for stronger open-access protections, ethical licensing models, and international standards to prevent monopolistic control. Some propose that non-profit and community-based models be protected or prioritized in future regulatory frameworks to ensure the equitable and culturally sensitive development of psychedelic therapies.


Methods


Standard psychedelic therapy

The main approach used in the contemporary resurgence of research, often simply called ''psychedelic therapy'', involves the use of moderate-to-high doses of psychedelic drugs. The psychedelic therapy method was initiated by
Humphry Osmond Humphry Fortescue Osmond (1 July 1917 – 6 February 2004) was an English psychiatrist who moved to Canada and later the United States. He is known for inventing the word '' psychedelic'' and for his research into interesting and useful applicat ...
and
Abram Hoffer Abram Hoffer (November 11, 1917 – May 27, 2009) was a Canadian biochemist, physician, and psychiatrist known for his "adrenochrome hypothesis" of schizoaffective disorders. According to Hoffer, megavitamin therapy and other nutritional interv ...
(with some influence from Al Hubbard) and replicated by Keith Ditman, and is more closely aligned to
transpersonal psychology Transpersonal psychology, or spiritual psychology, is an area of psychology that seeks to integrate the spiritual and transcendent human experiences within the framework of modern psychology. Evolving from the humanistic psychology movement, ...
than to traditional
psychoanalysis PsychoanalysisFrom Greek language, Greek: and is a set of theories and techniques of research to discover unconscious mind, unconscious processes and their influence on conscious mind, conscious thought, emotion and behaviour. Based on The Inte ...
. Most recent research on psychedelic therapy has used
psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...
or
ayahuasca AyahuascaPronounced as in the UK and in the US. Also occasionally known in English as ''ayaguasca'' (Spanish-derived), ''aioasca'' (Brazilian Portuguese-derived), or as ''yagé'', pronounced or . Etymologically, all forms but ''yagé'' descen ...
. Patients spend most of the acute period of the drug's activity lying down with eyeshades listening to music selected beforehand and exploring their inner experience. Dialogue with the therapists the drug session(s) but essential during the preparation session before and the integration session afterwards. The therapeutic team normally consists of a man and a woman, who are both present throughout the
psychedelic experience A psychedelic experience (known colloquially as a trip) is a temporary altered state of consciousness induced by the consumption of a psychedelic substance (most commonly Lysergic acid diethylamide, LSD, mescaline, psilocybin mushrooms, or N,N- ...
. One aspect that occurs in most participants undergoing psychedelic therapy with moderate-to-high doses is transcendental,
mystical Mysticism is popularly known as becoming one with God or the Absolute, but may refer to any kind of ecstasy or altered state of consciousness which is given a religious or spiritual meaning. It may also refer to the attainment of insight ...
, or
peak experience A peak experience is an altered state of consciousness characterized by euphoria, often achieved by self-actualizing individuals. The concept was originally developed by psychologist Abraham Maslow in mid-1940s and term was coined by him in 1956 ...
s. Research has suggested that the strength of these experiences, together with discussion of them soon after in a therapeutic session, could be a major determinant of how great the longer-term effects on symptoms will be. Some studies of psychedelic therapy have incorporated
cognitive behavioral therapy Cognitive behavioral therapy (CBT) is a form of psychotherapy that aims to reduce symptoms of various mental health conditions, primarily depression, PTSD, and anxiety disorders. Cognitive behavioral therapy focuses on challenging and chang ...
(CBT) or
motivational enhancement therapy Motivational enhancement therapy (MET) is a time-limited, four-session adaptation used in Project MATCH, a U.S.-government-funded study of treatment for alcohol problems, and the "Drinkers' Check-up", which provides normative-based feedback and e ...
(MET). Within a structured CBT intervention and a dose of psilocybin, patients are given the opportunity to experience cognitive and emotional states that are altered. With these psychedelic effects,
cognitive reframing Cognitive reframing is a psychological technique that consists of identifying and then changing the way situations, experiences, events, ideas and emotions are viewed. Cognitive reframing is the process by which such situations or thoughts are chal ...
of detrimental schemas and self-identity can be modified positively. In a MET environment, patients are able to reflect on their own behaviors to make changes in problematic manners, such as
alcohol use disorder Alcoholism is the continued drinking of alcohol despite it causing problems. Some definitions require evidence of dependence and withdrawal. Problematic use of alcohol has been mentioned in the earliest historical records. The World Hea ...
. Additionally, it could potentially enhance motivation to change and decrease possible ambivalence about behavioral changes. Within psychedelic drug sessions, through a reevaluation of the concept of self and reconnecting with core beliefs and values, this can be achieved. Psychedelic-assisted
group psychotherapy Group psychotherapy or group therapy is a form of psychotherapy in which one or more therapists treat a small group of clients together as a group. The term can legitimately refer to any form of psychotherapy when delivered in a group format, i ...
can be more cost-efficient, because therapists can split the costs among all participants of the group.


Psycholytic therapy

Psycholytic therapy involves the use of low-to-medium doses of psychedelic drugs, repeatedly at intervals of 1–2 weeks. The therapist is present during the peak of the experience to assist the patient in processing material that arises and to offer support. This general form of therapy was mostly used to treat patients with neurotic and psychosomatic disorders. The name psycholytic therapy was coined by Ronald A. Sandison, literally meaning "soul-dissolving", refers to the belief that the therapy can dissolve conflicts in the mind. Psycholytic therapy was historically an important approach to psychedelic psychotherapy in
Europe Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere. It is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, the Mediterranean Sea to the south, and Asia to the east ...
, and was also practiced in the United States by some psychotherapists, including Betty Eisner. In the time since the 1970s, psycholytic therapy has not been a focus of research. Psychedelic drugs are useful for exploring the subconscious because a conscious sliver of the adult ego usually remains active during the experience. Patients remain intellectually alert throughout the process and remember their experiences vividly afterward. In this highly introspective state, patients are actively aware of ego defenses such as projection, denial, and displacement as they react to themselves and their choices. The ultimate goal of the therapy is to provide a safe, mutually compassionate context through which the profound and intense reliving of memories can be filtered through the principles of genuine psychotherapy. Aided by the deeply introspective state attained by the patient, the therapist assists him/her in developing a new life framework or personal philosophy that recognizes individual responsibility for change. In Germany,
Hanscarl Leuner Hanscarl Leuner (born 8 January 1919 in Bautzen - d. 22 June 1996 in Göttingen) was a German psychiatrist, psychotherapist and researcher. He is the founder of "Psycholytic Therapy" also known as Guided Affective Imagery (":de:Katathym Imaginat ...
designed a form of psycholytic therapy, which was developed officially but was also used by some socio-politically motivated underground therapists in the 1970s. In Switzerland, Friedericke Meckel Fisher (trained by
Stanislav Grof Stanislav Grof (born July 1, 1931) is a Czech-born American psychiatrist. Grof is one of the principal developers of transpersonal psychology and research into the use of non-ordinary states of consciousness for purposes of psychological hea ...
in Breathwork and Samuel Widmer in group psychedelic sessions) practiced group psycholytic therapy mainly from the early 2000s and until 2015. Meckel Fischer developed her own system of psycholytic therapy which she conducted underground, in group weekend sessions of 15 to 19 people, using medium dosages of psychedelic substances. She added and combined into this psycholytic group work, techniques of her own modified family constellation work, cathartic body work, evocative music, and periods of sharing and feedback within the group.


Other variations


Claudio Naranjo

The Chilean therapist
Claudio Naranjo Claudio Benjamín Naranjo Cohen (24 November 1932 – 12 July 2019) was a Chilean psychiatrist who is considered a pioneer in integrating psychotherapy and the spiritual traditions. He was one of the three successors named by Fritz Perls (foun ...
developed a branch of psychedelic therapy that utilized drugs like
MDA MDA, mda or variants may refer to: Businesses and organizations Political parties * Meghalaya Democratic Alliance (2003–2008), in India * Meghalaya Democratic Alliance (2018–present), in India * Movement for Democracy in Africa, in Burkina F ...
,
MDMA 3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (tablet form), and molly (crystal form), is an empathogen–entactogenic drug with stimulant and minor Psychedelic drug, psychedelic properties. In studies, it has been used ...
,
harmaline Harmaline, also known as 7-methoxyharmalan or as 3,4-dihydro-7-methoxy-1-methyl-β-carboline, is a fluorescent indole alkaloid from the group of harmala alkaloids and β-carbolines. It is the partly hydrogenated form of harmine. It is a rever ...
, and
ibogaine Ibogaine is a psychoactive indole alkaloid derived from plants such as '' Tabernanthe iboga'', characterized by hallucinogenic and oneirogenic effects. Traditionally used by Central African foragers, it has undergone controversial research ...
.


Anaclitic therapy

The term '' anaclitic'' (from the Ancient Greek "ἀνάκλιτος", ''anaklitos'' – "for reclining") refers to primitive, infantile needs and tendencies directed toward a pre-genital love object. Developed by two London psychoanalysts, Joyce Martin and Pauline McCririck, this form of treatment is similar to psycholytic approaches as it is based largely on a psychoanalytic interpretation of abreactions produced by the treatment, but it tends to focus on those experiences in which the patient re-encounters carnal feelings of emotional deprivation and frustration stemming from the infantile needs of their early childhood. As a result, the treatment was developed with the aim to directly fulfill or satisfy those repressed, agonizing cravings for love, physical contact, and other instinctual needs re-lived by the patient. Therefore, the therapist is completely engaged with the subject, as opposed to the traditional detached attitude of the psychoanalyst. With the intense emotional episodes that came with the psychedelic experience, Martin and McCririck aimed to sit in as the "mother" role who would enter into close physical contact with the patients by rocking them, giving them milk from a bottle, etc.


Hypnodelic therapy

Hypnodelic therapy, as the name suggests, was developed with the goal to maximize the power of hypnotic suggestion by combining it with the psychedelic experience. After training the patient to respond to hypnosis, LSD would be administered, and during the onset phase of the drug the patient would be placed into a state of trance. Levine and Ludwig found the combination of these techniques to be more effective than the use of either of these two components separately.


Public interest

A resurgence of public interest in psychedelic drug therapy in the 21st century has been driven in part by articles in ''
The New Yorker ''The New Yorker'' is an American magazine featuring journalism, commentary, criticism, essays, fiction, satire, cartoons, and poetry. It was founded on February 21, 1925, by Harold Ross and his wife Jane Grant, a reporter for ''The New York T ...
'', ''
The New York Times ''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of ...
'', and ''
The Wall Street Journal ''The Wall Street Journal'' (''WSJ''), also referred to simply as the ''Journal,'' is an American newspaper based in New York City. The newspaper provides extensive coverage of news, especially business and finance. It operates on a subscriptio ...
''.


Psychedelic tourism

The first article to bring attention to the uses of psychedelic drugs for mental health was titled, "Seeking the Magic Mushroom", written by Robert Gordon Wasson and published in 1957 by ''TIME'' magazine. It detailed his experience traveling to Oaxaca, Mexico, and taking "magic mushrooms" (psilocybin) within the cultural practices that started the "trip" experience. Since that time, there has been growing interest within the United States to travel for these unique psychedelic experiences. The market for psychedelic tourism is currently growing rapidly. While typically the vacation destinations for psychedelics are based in Central and South America, there is a rise in western culture taking over their traditional practices. In the Netherlands, there are psychedelic society retreats ranging in cost from $500–1200 that center on a ceremony in which tourists take magic mushrooms and trip together for around six hours. There are also underground psychedelic "guides" popping up around the United States that include leaders who claim to assist people through their trip similar to shamans in other cultures. An article in ''
The Guardian ''The Guardian'' is a British daily newspaper. It was founded in Manchester in 1821 as ''The Manchester Guardian'' and changed its name in 1959, followed by a move to London. Along with its sister paper, ''The Guardian Weekly'', ''The Guardi ...
'' entitled "Welcome to the trip of your life: the rise of underground LSD guides" details various styles of guides that can be found within the United States.


Psilocybin therapy

Psilocybin therapy is the use of
psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...
(the psychoactive ingredient in
psilocybin mushrooms Psilocybin mushrooms, or psilocybin-containing mushrooms, commonly known as magic mushrooms or as shrooms, are a type of hallucinogenic mushroom and a polyphyletic informal group of fungi that contain the prodrug psilocybin, which turns into t ...
) in treating a range of mental health conditions, such as depression, anxiety, addictions, obsessive compulsive disorder, and psychosis. As of January 1, 2023, psilocybin services facilitator training is available for individuals aged 21 and above who are
Oregon Oregon ( , ) is a U.S. state, state in the Pacific Northwest region of the United States. It is a part of the Western U.S., with the Columbia River delineating much of Oregon's northern boundary with Washington (state), Washington, while t ...
residents. To become a psilocybin facilitator, an individual must complete a 120-hour regulated facilitator course, after which they may guide a client through a psilocybin experience. The facilitator may not engage the client in therapy; the therapeutic sessions held before and after the psilocybin experience itself are held by a
psychotherapist Psychotherapy (also psychological therapy, talk therapy, or talking therapy) is the use of Psychology, psychological methods, particularly when based on regular Conversation, personal interaction, to help a person change behavior, increase hap ...
. As of March 2023, there are currently graduates who can practice as licensed facilitators; however, no licensed service centers are yet operating.


See also

* :Psychedelic drug researchers *
Concord Prison Experiment The Concord Prison Experiment, conducted from 1961 to 1963, was designed to evaluate whether the experiences produced by the psychoactive drug psilocybin, derived from psilocybin mushrooms, combined with psychotherapy, could inspire prisoners to ...
*
Hallucinogen Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mo ...
*
History of lysergic acid diethylamide The psychedelic drug (or entheogen) lysergic acid diethylamide (LSD) was first synthesized on November 16, 1938, by the Swiss chemist Albert Hofmann in the Sandoz laboratories in Basel, Switzerland.Albert Hofmann; translated from the original Ge ...
(LSD) *
James Fadiman James Fadiman (born May 27, 1939) is an American writer known for his research on microdosing psychedelics. He co-founded the Institute of Transpersonal Psychology, which later became Sofia University. Early years Fadiman was born in New York ...
*
Psilocybin decriminalization in the United States The movement to Legal status of psilocybin mushrooms, decriminalize psilocybin in the United States began in 2019 with Denver, Colorado, becoming the first city to decriminalize psilocybin in May of that year. The cities of Oakland and Santa Cruz, ...
* *
Psychedelic microdosing Psychedelic microdosing is a form of microdosing, drug microdosing in which sub-hallucinogenic doses of serotonergic psychedelics like LSD and psilocybin are taken for claimed cognitive and emotional benefits. Uses, research, and effects A vari ...
*
Rick Doblin Richard Elliot Doblin (born November 30, 1953) is an American psychedelic drug advocate who is the founder and president of the Multidisciplinary Association for Psychedelic Studies (MAPS). Early life and education Rick Doblin grew up in Skokie ...
* Robin Carhart-Harris * Roland R. Griffiths *
Psychoplastogen Psychoplastogens, also known as neuroplastogens, are a group of Small molecule#Drugs, small molecule drugs that produce rapid and sustained effects on neuronal structure and function, intended to manifest therapeutic benefit after a single admin ...


Notes


References


External links


History of LSD Therapy
(Ch. 1 of Grof's, ''LSD Psychotherapy'')
''Reimbursement Pathways for Psychedelic Therapies in Europe''
Magnetar Access & Blossom
The Second International Conference on the Use of LSD in Psychotherapy and Alcoholism
{{Webarchive, url=https://web.archive.org/web/20160305172208/https://www.scribd.com/doc/26114289/The-Second-International-Conference-on-the-Use-of-LSD-in-Psychotherapy-and-Alcoholism , date=2016-03-05 (1967) (entire book) Alternative medical treatments History of psychiatry Psychedelic drug research Psychiatric research