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Constantin von Monakow (4 November 1853 – 19 October 1930) was a Russian-Swiss
neuropathologist Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole-body autopsies. Neuropathologists usually work in a department of anatomic pathology, but work closely with the cli ...
who was a native of Bobretsovo in the
Vologda Governorate Vologda Governorate (), also known as the Government of Vologda, was an administrative-territorial unit (''guberniya'') of the Russian Empire and the Russian Soviet Federative Socialist Republic, Russian SFSR, which existed from 1796 until 1929. ...
. He studied at the
University of Zurich The University of Zurich (UZH, ) is a public university, public research university in Zurich, Switzerland. It is the largest university in Switzerland, with its 28,000 enrolled students. It was founded in 1833 from the existing colleges of the ...
while working as an assistant at the
Burghölzli Burghölzli, named after the wooded hill in the district of Riesbach in southeastern Zürich where it is located, is the ''Psychiatrische Universitätsklinik Zürich'' ('Psychiatric University Hospital Zürich'), a psychiatric hospital in Switzerl ...
Institute under the directorship of
Eduard Hitzig Eduard Hitzig (6 February 1838 – 20 August 1907) was a German neurologist and neuropsychiatrist of Jewish ancestryAndrew P. Wickens, ''A History of the Brain: From Stone Age Surgery to Modern Neuroscience'', Psychology Press (2014), p. 226 ...
(1839-1907). After graduation, he was an assistant at St. Pirminsberg, where he performed scientific investigations of cerebral
anatomy Anatomy () is the branch of morphology concerned with the study of the internal structure of organisms and their parts. Anatomy is a branch of natural science that deals with the structural organization of living things. It is an old scien ...
. In 1885 he returned to
Zurich Zurich (; ) is the list of cities in Switzerland, largest city in Switzerland and the capital of the canton of Zurich. It is in north-central Switzerland, at the northwestern tip of Lake Zurich. , the municipality had 448,664 inhabitants. The ...
, where he later became director of the brain anatomy institute. In 1917 he founded the journal ''Schweizer Archiv für Neurologie und Psychiatrie'' (Swiss Archives of Neurology and Psychiatry), and was its editor-in-chief until his death. He died in Zurich in 1930.


Neuropathological research

Monakow made numerous contributions in his analysis of the sensory and motor pathways of the brain. He was interested in the functional relationships amongst the different regions of the brain, and conceptualized that in faculties such as
intellect Intellect is a faculty of the human mind that enables reasoning, abstraction, conceptualization, and judgment. It enables the discernment of truth and falsehood, as well as higher-order thinking beyond immediate perception. Intellect is dis ...
, coordination was needed among its many diverse parts. From his brain research, he introduced the terms "chronogenic localization" and " diaschisis". In 1910 Monakow coined the term "diaschisis" to describe how an injury to the brain can create behavioral deficiencies that may be followed by eventual recovery. The word is derived from Greek, meaning "shocked throughout". He believed the brain to exist as a delicate balance between its different components, and if a component became disturbed through injury it could affect other parts of the brain not seemingly associated with the site of injury. Therefore, if the damage wasn't too severe, functional behaviour would recover once the period of diaschisis wore off. His name is lent to "Monakow's nucleus" ( lateral cuneate nucleus) and to the "bundle of Monakow" ( rubrospinal fasciculus). In addition, "Monakow's syndrome" bears his name, defined as contralateral
hemiplegia Hemiparesis, also called unilateral paresis, is the weakness of one entire side of the body ('' hemi-'' means "half"). Hemiplegia, in its most severe form, is the complete paralysis of one entire side of the body. Either hemiparesis or hemiplegia ...
, hemi
anaesthesia Anesthesia (American English) or anaesthesia (British English) is a state of controlled, temporary loss of sensation or awareness that is induced for medical or veterinary purposes. It may include some or all of analgesia (relief from or prev ...
and homonomous hemianopsia due to occlusion of the anterior choroidal artery. He was responsible for identifying the
arcuate fasciculus In neuroanatomy, the arcuate fasciculus (AF; ) is a bundle of axons that generally connects Broca's area and Wernicke's area in the brain. It is an association fiber tract connecting caudal temporal lobe and inferior frontal lobe. Structure ...
as the fibre tract that connected the Broca's and Wernicke's speech areas. This anatomical link (which is now questioned)Catani M, Mesulam M. (2008). The arcuate fasciculus and the disconnection theme in language and aphasia: history and current state. Cortex. 44(8):953-61. “soon became a dogma in neurology and still today provides the backbone of anatomical models of language.” He is mentioned in ''Anti Oedipus'', the first volume of Deleuze and Guattari's ''Capitalism and Schizophrenia'', because of his work with Mourgue which they claim posits 'the introduction of desire into neurology.'


Selected writings

* ''Beitrag zur Localisation von Hirnrindentumoren'', (Thesis/dissertation) (1881) – On localization of cerebral cortex tumors. * ''Pathologie du cerveau'', in German as ''Gehirnpathologie'' (1897) – Brain pathology. * ''Über Lokalisation der Hirnfunktion'' (1910) – On localization of brain function. * ''La localisation de l'encéphale et la dégradation fonctionelle par des lésions circonscrites du cortex cérébral'', in German as ''Die Lokalisation im Grosshirn und Abbau der Funktion durch kortikale Herde'' (1914) – Localization in the cortex and the reduction of cortical function. * ''Gefuhl, Gesittung und Gehirn'', (1916); translated and published in English as "The emotions, morality and the brain"; Washington, Nervous and Mental Disease Pub. Co., 1925.WorldCat Search
published works by Monachow
* ''Psychiatrie und Biologie'', (1919) – Psychology and
biology Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, History of life, origin, evolution, and ...
. * ''Schizophrenie und Plexus chorioidei'' (with Kitabayashi), (1919) -
Schizophrenia Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, f ...
and the
choroid plexus The choroid plexus, or plica choroidea, is a plexus of cells that arises from the tela choroidea in each of the ventricles of the brain. Regions of the choroid plexus produce and secrete most of the cerebrospinal fluid (CSF) of the central ...
.


References


Vologda Oblast Government, Biography


External links



* ttp://members.tripod.com/~ThJuland/neurons.html Monakow and Diaschisis {{DEFAULTSORT:Monakow, Constantin von Emigrants from the Russian Empire to Switzerland Neurologists from the Russian Empire Swiss neurologists 1853 births 1930 deaths People associated with the University of Zurich History of psychiatry