Cognitive neuroscience is the scientific field that is concerned with the study of the

biological Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary ...

processes and aspects that underlie

cognition Cognition refers to "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses". It encompasses all aspects of intellectual functions and processes such as: perception, attention, thoug ...

, with a specific focus on the neural connections in the brain which are involved in mental processes. It addresses the questions of how cognitive activities are affected or controlled by neural circuits in the brain. Cognitive neuroscience is a branch of both

neuroscience Neuroscience is the science, scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a Multidisciplinary approach, multidisciplinary science that combines physiology, an ...

and

psychology Psychology is the scientific study of mind and behavior. Psychology includes the study of conscious and unconscious phenomena, including feelings and thoughts. It is an academic discipline of immense scope, crossing the boundaries betwe ...

, overlapping with disciplines such as behavioral neuroscience, cognitive psychology, physiological psychology and affective neuroscience.Gazzaniga 2002, p. xv Cognitive neuroscience relies upon theories in cognitive science coupled with evidence from neurobiology, and

computational modeling Computer simulation is the process of mathematical modelling, performed on a computer, which is designed to predict the behaviour of, or the outcome of, a real-world or physical system. The reliability of some mathematical models can be dete ...

. Parts of the brain play an important role in this field.

Neuron A neuron, neurone, or nerve cell is an membrane potential#Cell excitability, electrically excitable cell (biology), cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous ...

s play the most vital role, since the main point is to establish an understanding of cognition from a neural perspective, along with the different lobes of the

cerebral cortex The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting o ...

. Methods employed in cognitive neuroscience include experimental procedures from psychophysics and cognitive psychology, functional neuroimaging, electrophysiology, cognitive genomics, and

behavioral genetics Behavioural genetics, also referred to as behaviour genetics, is a field of science, scientific research that uses genetics, genetic scientific method, methods to investigate the etiology, nature and origins of Differential psychology, indivi ...

. Studies of patients with cognitive deficits due to brain lesions constitute an important aspect of cognitive neuroscience. The damages in lesioned brains provide a comparable starting point on regards to healthy and fully functioning brains. These damages change the neural circuits in the brain and cause it to malfunction during basic cognitive processes, such as

memory Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed. It is the retention of information over time for the purpose of influencing future action. If past events could not be remembered ...

or learning. People have learning disabilities and such damage, can be compared with how the healthy neural circuits are functioning, and possibly draw conclusions about the basis of the affected cognitive processes. Some examples of learning disabilities in the brain include places in Wernicke's area, the left side of the temporal lobe, and Brocca's area close to the frontal lobe. Also, cognitive abilities based on brain development are studied and examined under the subfield of developmental cognitive neuroscience. This shows brain development over time, analyzing differences and concocting possible reasons for those differences. Theoretical approaches include

computational neuroscience Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of neuroscience which employs mathematical models, computer simulations, theoretical analysis and abstractions of the brain to ...

and cognitive psychology.

Historical origins

Cognitive neuroscience is an interdisciplinary area of study that has emerged from

and

.Kosslyn, S, M. & Andersen, R, A. (1992). Frontiers in cognitive neuroscience. Cambridge, MA: MIT press. There are several stages in these disciplines that have changed the way researchers approached their investigations and that led to the field becoming fully established. Although the task of cognitive neuroscience is to describe the neural mechanisms associated with the mind, historically it has progressed by investigating how a certain area of the brain supports a given mental faculty. However, early efforts to subdivide the brain proved to be problematic. The phrenologist movement failed to supply a scientific basis for its theories and has since been rejected. The aggregate field view, meaning that all areas of the brain participated in all behavior, was also rejected as a result of brain mapping, which began with Hitzig and

Fritsch Fritsch is a German surname. Like Fritsche, Fritzsch and Fritzsche, it is a patronymic derived from Friedrich. Notable people with the surname include: *Ahasverus Fritsch (1629–1701), German jurist, poet and hymn writer * Antonin Fritsch (1832 ...

's experiments and eventually developed through methods such as

positron emission tomography Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, ...

(PET) and functional magnetic resonance imaging (fMRI). Gestalt theory, neuropsychology, and the cognitive revolution were major turning points in the creation of cognitive neuroscience as a field, bringing together ideas and techniques that enabled researchers to make more links between behavior and its neural substrates.

Origins in philosophy

Philosophers have always been interested in the mind: "the idea that explaining a phenomenon involves understanding the mechanism responsible for it has deep roots in the History of Philosophy from atomic theories in 5th century B.C. to its rebirth in the 17th and 18th century in the works of Galileo, Descartes, and Boyle. Among others, it's Descartes' idea that machines humans build could work as models of scientific explanation." For example,

Aristotle Aristotle (; grc-gre, Ἀριστοτέλης ''Aristotélēs'', ; 384–322 BC) was a Greek philosopher and polymath during the Classical Greece, Classical period in Ancient Greece. Taught by Plato, he was the founder of the Peripatet ...

thought the brain was the body's cooling system and the capacity for intelligence was located in the heart. It has been suggested that the first person to believe otherwise was the Roman physician

Galen Aelius Galenus or Claudius Galenus ( el, Κλαύδιος Γαληνός; September 129 – c. AD 216), often Anglicized as Galen () or Galen of Pergamon, was a Greek physician, surgeon and philosopher in the Roman Empire. Considered to be on ...

in the second century AD, who declared that the brain was the source of mental activity, although this has also been accredited to Alcmaeon. However, Galen believed that personality and emotion were not generated by the brain, but rather by other organs. Andreas Vesalius, an anatomist and physician, was the first to believe that the brain and the nervous system are the center of the mind and emotion.

Psychology Psychology is the scientific study of mind and behavior. Psychology includes the study of conscious and unconscious phenomena, including feelings and thoughts. It is an academic discipline of immense scope, crossing the boundaries betwe ...

, a major contributing field to cognitive neuroscience, emerged from philosophical reasoning about the mind.

19th century

Phrenology

One of the predecessors to cognitive neuroscience was phrenology, a pseudoscientific approach that claimed that behavior could be determined by the shape of the

scalp The scalp is the anatomical area bordered by the human face at the front, and by the neck at the sides and back. Structure The scalp is usually described as having five layers, which can conveniently be remembered as a mnemonic: * S: The s ...

. In the early 19th century, Franz Joseph Gall and J. G. Spurzheim believed that the human brain was localized into approximately 35 different sections. In his book, The Anatomy and Physiology of the Nervous System in General, and of the Brain in Particular, Gall claimed that a larger bump in one of these areas meant that that area of the brain was used more frequently by that person. This theory gained significant public attention, leading to the publication of phrenology journals and the creation of phrenometers, which measured the bumps on a human subject's head. While phrenology remained a fixture at fairs and carnivals, it did not enjoy wide acceptance within the scientific community. The major criticism of phrenology is that researchers were not able to test theories empirically.

Localizationist view

The localizationist view was concerned with mental abilities being localized to specific areas of the brain rather than on what the characteristics of the abilities were and how to measure them. Studies performed in Europe, such as those of

John Hughlings Jackson John Hughlings Jackson, FRS (4 April 1835 – 7 October 1911) was an English neurologist. He is best known for his research on epilepsy. Biography He was born at Providence Green, Green Hammerton, near Harrogate, Yorkshire, the youngest ...

, supported this view. Jackson studied patients with

brain damage Neurotrauma, brain damage or brain injury (BI) is the destruction or degeneration of brain cells. Brain injuries occur due to a wide range of internal and external factors. In general, brain damage refers to significant, undiscriminating t ...

, particularly those with

epilepsy Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrical ...

. He discovered that the epileptic patients often made the same clonic and tonic movements of muscle during their seizures, leading Jackson to believe that they must be caused be activity in the same place in the brain every time. Jackson proposed that specific functions were localized to specific areas of the brain, which was critical to future understanding of the brain lobes.

Aggregate field view

According to the aggregate field view, all areas of the brain participate in every mental function. Pierre Flourens, a French experimental psychologist, challenged the localizationist view by using animal experiments. He discovered that removing the

cerebellum The cerebellum (Latin for "little brain") is a major feature of the hindbrain of all vertebrates. Although usually smaller than the cerebrum, in some animals such as the mormyrid fishes it may be as large as or even larger. In humans, the cere ...

(brain) in rabbits and pigeons affected their sense of muscular coordination, and that all cognitive functions were disrupted in pigeons when the

cerebral hemisphere The vertebrate cerebrum (brain) is formed by two cerebral hemispheres that are separated by a groove, the longitudinal fissure. The brain can thus be described as being divided into left and right cerebral hemispheres. Each of these hemispheres ...

s were removed. From this he concluded that the

, and

brainstem The brainstem (or brain stem) is the posterior stalk-like part of the brain that connects the cerebrum with the spinal cord. In the human brain the brainstem is composed of the midbrain, the pons, and the medulla oblongata. The midbrain is ...

functioned together as a whole.Boring, E.G. (1957). A history of experimental psychology. New York. His approach has been criticised on the basis that the tests were not sensitive enough to notice selective deficits had they been present.

Emergence of neuropsychology

Perhaps the first serious attempts to localize mental functions to specific locations in the brain was by Broca and Wernicke. This was mostly achieved by studying the effects of injuries to different parts of the brain on psychological functions. In 1861, French neurologist Paul Broca came across a man with a disability who was able to understand the language but unable to speak. The man could only produce the sound "tan". It was later discovered that the man had damage to an area of his left frontal lobe now known as Broca's area. Carl Wernicke, a German neurologist, found a patient who could speak fluently but non-sensibly. The patient had been the victim of a stroke, and could not understand spoken or written language. This patient had a lesion in the area where the left parietal and temporal lobes meet, now known as Wernicke's area. These cases, which suggested that lesions caused specific behavioral changes, strongly supported the localizationist view. Additionally, Aphasia is a learning disorder which was also discovered by Paul Broca. According to, Johns Hopkins School of Medicine, Aphasia is a language disorder caused by damage in a specific area of the brain that controls language expression and comprehension. This can often lead to the person speaking words with no sense known as "word salad"

Mapping the brain

In 1870, German physicians Eduard Hitzig and Gustav Fritsch published their findings of the behavior of animals. Hitzig and Fritsch ran an electric current through the cerebral cortex of a dog, causing different muscles to contract depending on which areas of the brain were electrically stimulated. This led to the proposition that individual functions are localized to specific areas of the brain rather than the cerebrum as a whole, as the aggregate field view suggests. Brodmann was also an important figure in brain mapping; his experiments based on Franz Nissl's tissue staining techniques divided the brain into fifty-two areas.

20th century

Cognitive revolution

At the start of the 20th century, attitudes in America were characterized by pragmatism, which led to a preference for behaviorism as the primary approach in

. J.B. Watson was a key figure with his stimulus-response approach. By conducting experiments on animals he was aiming to be able to predict and control behavior. Behaviorism eventually failed because it could not provide realistic psychology of human action and thought – it focused primarily on stimulus-response associations at the expense of explaining phenomena like thought and imagination. This led to what is often termed as the "cognitive revolution".

Neuron doctrine

In the early 20th century, Santiago Ramón y Cajal and Camillo Golgi began working on the structure of the neuron. Golgi developed a silver staining method that could entirely stain several cells in a particular area, leading him to believe that neurons were directly connected with each other in one cytoplasm. Cajal challenged this view after staining areas of the brain that had less myelin and discovering that neurons were discrete cells. Cajal also discovered that cells transmit electrical signals down the neuron in one direction only. Both Golgi and Cajal were awarded a Nobel Prize in Physiology or Medicine in 1906 for this work on the neuron doctrine.

Mid-late 20th century

Several findings in the 20th century continued to advance the field, such as the discovery of ocular dominance columns, recording of single nerve cells in animals, and coordination of eye and head movements. Experimental psychology was also significant in the foundation of cognitive neuroscience. Some particularly important results were the demonstration that some tasks are accomplished via discrete processing stages, the study of attention, and the notion that behavioural data do not provide enough information by themselves to explain mental processes. As a result, some experimental psychologists began to investigate neural bases of behaviour. Wilder Penfield created maps of primary sensory and motor areas of the brain by stimulating the cortices of patients during surgery. The work of Sperry and Gazzaniga on split brain patients in the 1950s was also instrumental in the progress of the field. The term cognitive neuroscience itself was coined by Gazzaniga and cognitive psychologist

George Armitage Miller George Armitage Miller (February 3, 1920 – July 22, 2012) was an American psychologist who was one of the founders of cognitive psychology, and more broadly, of cognitive science. He also contributed to the birth of psycholinguistics. Mille ...

while sharing a taxi in 1976.

Brain mapping

New brain mapping technology, particularly fMRI and PET, allowed researchers to investigate experimental strategies of cognitive psychology by observing brain function. Although this is often thought of as a new method (most of the technology is relatively recent), the underlying principle goes back as far as 1878 when blood flow was first associated with brain function. Angelo Mosso, an Italian psychologist of the 19th century, had monitored the pulsations of the adult brain through neurosurgically created bony defects in the skulls of patients. He noted that when the subjects engaged in tasks such as mathematical calculations the pulsations of the brain increased locally. Such observations led Mosso to conclude that blood flow of the brain followed function.

Emergence of a new discipline

Birth of cognitive science

On September 11, 1956, a large-scale meeting of cognitivists took place at the

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a Private university, private Land-grant university, land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern t ...

. George A. Miller presented his " The Magical Number Seven, Plus or Minus Two" paper while

Noam Chomsky Avram Noam Chomsky (born December 7, 1928) is an American public intellectual: a linguist, philosopher, cognitive scientist, historian, social critic, and political activist. Sometimes called "the father of modern linguistics", Chomsky is ...

and Newell & Simon presented their findings on

computer science Computer science is the study of computation, automation, and information. Computer science spans theoretical disciplines (such as algorithms, theory of computation, information theory, and automation) to practical disciplines (includin ...

. Ulric Neisser commented on many of the findings at this meeting in his 1967 book ''Cognitive Psychology''. The term "psychology" had been waning in the 1950s and 1960s, causing the field to be referred to as "cognitive science". Behaviorists such as Miller began to focus on the representation of language rather than general behavior. David Marr concluded that one should understand any cognitive process at three levels of analysis. These levels include computational, algorithmic/representational, and physical levels of analysis.

Combining neuroscience and cognitive science

Before the 1980s, interaction between neuroscience and cognitive science was scarce.not available

not available Cognitive neuroscience began to integrate the newly laid theoretical ground in cognitive science, that emerged between the 1950s and 1960s, with approaches in experimental psychology, neuropsychology and neuroscience. (Neuroscience was not established as a unified discipline until 1971). In the very late 20th century new technologies evolved that are now the mainstay of the methodology of cognitive neuroscience, including Transcranial magnetic stimulation, TMS (1985) and fMRI (1991). Earlier methods used in cognitive neuroscience include EEG (human EEG 1920) and

MEG Meg is a feminine given name, often a short form of Megatron, Megan, Megumi (Japanese), etc. It may refer to: People *Meg (singer), a Japanese singer *Meg Cabot (born 1967), American author of romantic and paranormal fiction *Meg Burton Cahill ( ...

(1968). Occasionally cognitive neuroscientists utilize other brain imaging methods such as PET and SPECT. An upcoming technique in neuroscience is NIRS which uses light absorption to calculate changes in oxy- and deoxyhemoglobin in cortical areas. In some animals Single-unit recording can be used. Other methods include microneurography, facial EMG, and eye tracking. Integrative neuroscience attempts to consolidate data in databases, and form unified descriptive models from various fields and scales: biology, psychology, anatomy, and clinical practice. Adaptive resonance theory (ART) is a cognitive neuroscience theory developed by

Gail Carpenter Gail Alexandra Carpenter (born 1948) is an American cognitive scientist, neuroscientist and mathematician. She is now a "Professor Emerita of Mathematics and Statistics, Boston University." She had also been a Professor of Cognitive and Neural ...

and

Stephen Grossberg Stephen Grossberg (born December 31, 1939) is a cognitive scientist, theoretical and computational psychologist, neuroscientist, mathematician, biomedical engineer, and neuromorphic technologist. He is the Wang Professor of Cognitive and Neu ...

in the late 1970s on aspects of how the brain processes information. It describes a number of

neural network models Artificial neural networks (ANNs), usually simply called neural networks (NNs) or neural nets, are computing systems inspired by the biological neural networks that constitute animal brains. An ANN is based on a collection of connected units ...

which use supervised and unsupervised learning methods, and address problems such as pattern recognition and prediction.Carpenter, G.A., Grossberg, S., & Reynolds, J.H. (1991)
ARTMAP: Supervised real-time learning and classification of nonstationary data by a self-organizing neural network
, '' Neural Networks'', 4, 565-588 In 2014, Stanislas Dehaene, Giacomo Rizzolatti and Trevor Robbins, were awarded the

Brain Prize The Brain Prize, formerly known as The Grete Lundbeck European Brain Research Prize, is an international scientific award honouring "one or more scientists who have distinguished themselves by an outstanding contribution to neuroscience and who are ...

"for their pioneering research on higher brain mechanisms underpinning such complex human functions as literacy, numeracy, motivated behaviour and social cognition, and for their efforts to understand cognitive and behavioural disorders". Brenda Milner, Marcus Raichle and John O'Keefe received the Kavli Prize in Neuroscience "for the discovery of specialized brain networks for memory and cognition" and O'Keefe shared the

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine ( sv, Nobelpriset i fysiologi eller medicin) is awarded yearly by the Nobel Assembly at the Karolinska Institute, Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or ...

in the same year with

May-Britt Moser May-Britt Moser (born 4 January 1963) is a Norwegian psychologist and neuroscientist, who is a Professor of Psychology and Neuroscience at the Norwegian University of Science and Technology (NTNU). She and her then-husband, Edvard Moser, share ...

and Edvard Moser "for their discoveries of cells that constitute a positioning system in the brain". In 2017,

Wolfram Schultz Wolfram may refer to: * Wolfram (name) * Wolfram, an alternative name for the chemical element tungsten * Wolfram Research, a software company known for the symbolic computation program Mathematica ** Wolfram Language, the programming language use ...

Peter Dayan Peter Dayan is director at the Max Planck Institute for Biological Cybernetics in Tübingen, Germany. He is co-author of ''Theoretical Neuroscience'', an influential textbook on computational neuroscience. He is known for applying Bayesian m ...

and

Ray Dolan Ray Dolan is an Irish singer-songwriter and guitarist. He began his career in the early 1970 by playing folk clubs in Dublin with James Connolly as a duo, contributing to the success of the Universal Folk Centre at Parnell Square.Insert from ''R ...

were awarded the Brain Prize "for their multidisciplinary analysis of brain mechanisms that link learning to reward, which has far-reaching implications for the understanding of human behaviour, including disorders of decision-making in conditions such as gambling, drug addiction, compulsive behaviour and schizophrenia".,

Recent trends

Recently the focus of research had expanded from the localization of brain area(s) for specific functions in the adult brain using a single technology. Studies have been diverging in several different directions: exploring the interactions between different brain areas, using multiple technologies and approaches to understand brain functions, and using computational approaches. Advances in non-invasive functional neuroimaging and associated data analysis methods have also made it possible to use highly naturalistic stimuli and tasks such as feature films depicting social interactions in cognitive neuroscience studies. Another very recent trend in cognitive neuroscience is the use of

optogenetics Optogenetics is a biological technique to control the activity of neurons or other cell types with light. This is achieved by expression of light-sensitive ion channels, pumps or enzymes specifically in the target cells. On the level of indiv ...

to explore circuit function and its behavioral consequences.

Topics

Attention Attention is the behavioral and cognitive process of selectively concentrating on a discrete aspect of information, whether considered subjective or objective, while ignoring other perceivable information. William James (1890) wrote that "Att ...

Consciousness Consciousness, at its simplest, is sentience and awareness of internal and external existence. However, the lack of definitions has led to millennia of analyses, explanations and debates by philosophers, theologians, linguisticians, and scien ...

Decision-making In psychology, decision-making (also spelled decision making and decisionmaking) is regarded as the cognitive process resulting in the selection of a belief or a course of action among several possible alternative options. It could be either r ...

* Emotions *

Intelligence Intelligence has been defined in many ways: the capacity for abstraction, logic, understanding, self-awareness, learning, emotional knowledge, reasoning, planning, creativity, critical thinking, and problem-solving. It can be described as the ...

Language Language is a structured system of communication. The structure of a language is its grammar and the free components are its vocabulary. Languages are the primary means by which humans communicate, and may be conveyed through a variety of ...

* Learning *

Memory Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed. It is the retention of information over time for the purpose of influencing future action. If past events could not be remembered ...

* Perception * Social cognition

Methods

Experimental methods include: * Psychophysics *

Eye-tracking Eye tracking is the process of measuring either the point of gaze (physiology), gaze (where one is looking) or the motion of an eye relative to the head. An eye tracker is a device for measuring eye positions and Eye movement (sensory), eye mo ...

* Functional magnetic resonance imaging * Electroencephalography * Magnetoencephalography * Electrocorticography * Transcranial Magnetic Stimulation *

Computational Modeling Computer simulation is the process of mathematical modelling, performed on a computer, which is designed to predict the behaviour of, or the outcome of, a real-world or physical system. The reliability of some mathematical models can be dete ...

References

External links