Coclaurine is a
nicotinic acetylcholine receptor
Nicotinic acetylcholine receptors, or nAChRs, are Receptor (biochemistry), receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the c ...
antagonist
An antagonist is a character in a story who is presented as the main enemy or rival of the protagonist and is often depicted as a villain.[Nelumbo nucifera
''Nelumbo nucifera'', also known as the pink lotus, sacred lotus, Indian lotus, or simply lotus, is one of two extant taxon, extant species of aquatic plant in the Family (biology), family Nelumbonaceae. It is sometimes colloquially called a ...](_b ...<br></span></div> which has been isolated from a variety of plant sources including ''<div class=)
'', ''
Sarcopetalum harveyanum
''Sarcopetalum harveyanum'', known as the pearl vine, is a common plant found mostly in coastal areas of eastern Australia. It can be found in or around rainforests, and is also seen in eucalyptus forests.
The leaf stalk is attached under the ...
'', ''
Ocotea duckei
''Ocotea'' is a genus of flowering plants belonging to the family Lauraceae. Many are evergreen trees with lauroid leaves.
There are over 520 species currently accepted within the genus, distributed mostly in tropical and subtropical areas of t ...
'',
and others. It belongs to the class of
tetrahydroisoquinoline
Tetrahydroisoquinoline (TIQ or THIQ), also known as AMPH-CR, is an organic compound with the chemical formula C9H11N. Classified as a secondary amine, it is derived from isoquinoline by hydrogenation. It is a colorless viscous liquid that is mis ...
alkaloid
Alkaloids are a broad class of natural product, naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids.
Alkaloids are produced by a large varie ...
s.
Dimerization
In chemistry, dimerization is the process of joining two identical or similar molecular entities by bonds. The resulting bonds can be either strong or weak. Many symmetrical chemical species are described as dimers, even when the monomer is u ...
of coclaurine leads to the alkaloids such as
cepharanthine
Cepharanthine is an antiinflammatory and antineoplastic compound isolated from ''Stephania''. Due to these modalities, it has been shown effective against HTLV
The primate T-lymphotropic viruses (PTLVs) are a group of retroviruses that infect ...
.
References
Nicotinic antagonists
Benzylisoquinoline alkaloids
4-Hydroxyphenyl compounds
Hydroxyarenes
{{alkaloid-stub