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Cepharanthine
Cepharanthine is an antiinflammatory and antineoplastic compound isolated from ''Stephania''. Due to these modalities, it has been shown effective against HTLV The primate T-lymphotropic viruses (PTLVs) are a group of retroviruses that infect primates, using their lymphocytes to reproduce. The ones that infect humans are known as human T-lymphotropic virus (HTLV), and the ones that infect Old World monk ... in lab research. Additionally, it has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported. References Benzylisoquinoline alkaloids Anti-inflammatory agents {{antineoplastic-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antiinflammatory
Anti-inflammatory is the property of a substance or treatment that reduces inflammation, fever or swelling. Anti-inflammatory drugs, also called anti-inflammatories, make up about half of analgesics. These drugs reduce pain by inhibiting mechanisms of inflammation, as opposed to opioids, which affect the central nervous system to block pain. Common anti-inflammatory drugs include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, antileukotrienes, and monoclonal antibodies. Drugs Clinically approved Nonsteroidal anti-inflammatory drugs NSAIDs alleviate pain by counteracting the cyclooxygenase (COX) enzyme involved in pain mechanisms. Some common examples of NSAIDs are aspirin, ibuprofen, and naproxen. Selective COX-2 inhibitors, such as celecoxib, block the enzymatic conversion of arachidonic acid into prostaglandin, inhibiting inflammation and pain. Analgesics commonly associated with anti-inflammatory drugs, such as acetaminophen (paracetamol), have no periph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stephania
''Stephania'' is a genus of flowering plants in the family Menispermaceae, native to eastern and southern Asia and Australia. They are herbaceous perennial vines, growing to around four metres tall, with a large tuber. The leaves are arranged spirally on the stem and are peltate, with the leaf petiole attached near the centre of the leaf. The name ''Stephania'' comes from the Greek, "a crown". This refers to the anthers being arranged in a crown-like manner. One species, '' S. tetrandra'', is among the 50 fundamental herbs used in traditional Chinese medicine, where it is called ''han fang ji'' (漢防己, "Chinese ''fang ji''"). Other plants named ''fang ji'' are sometimes substituted for it. Other varieties substituted include '' Cocculus thunbergii'', '' C. trulobus'', '' Aristolochia fangchi'', '' Stephania tetrandria'', and '' Sinomenium acutum''. Notable among these is ''guang fang ji'' (廣防己, "(GuangDong, GuangXi) fang ji", ''Aristolochia fangchi''. Because of its to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HTLV
The primate T-lymphotropic viruses (PTLVs) are a group of retroviruses that infect primates, using their lymphocytes to reproduce. The ones that infect humans are known as human T-lymphotropic virus (HTLV), and the ones that infect Old World monkeys are called simian T-lymphotropic viruses (STLVs). PTLVs are named for their ability to cause adult T-cell leukemia/lymphoma, but in the case of HTLV-1 it can also cause a demyelinating disease called tropical spastic paraparesis. On the other hand, newer PTLVs are simply placed into the group by similarity and their connection to human disease remains unclear. HTLVs have evolved from STLVs by interspecies transmission. Within each species of PTLV, the HTLV is more similar to its cognate STLV than to the other HTLVs. There are currently three species of PTLVs recognized by the ICTV (P/H/STLV-1, -2, -3), plus two that are reported but unrecognized (HTLV-4, STLV-5). The first known, and still most medically important PTLV is HTLV-1, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzylisoquinoline Alkaloids
The benzylisoquinoline alkaloids are natural products that can be classified as isoquinoline alkaloids and are derived from benzylisoquinoline. They also include the benzyl(tetrahydro)isoquinoline alkaloids. Occurrence Benzylisoquinoline alkaloids are found in several Plant family, plant families, including the poppy family (Papaveraceae), the Annonaceae, annonaceae family, and the laurel family. Well-known representatives are primarily found in poppy plants, specifically those from which opium is derived, as well as in Actaea (plant), actaea. For instance, reticuline has been isolated from Annona reticulata. Known representatives Over 2500 biologically active derivatives are known from the benzylisoquinoline alkaloids.Bettina Ruff: ''Chemical and Biochemical Methods for the Stereoselective Synthesis of Complex Natural Products'', 199 pages, Verlag Logos Berlin (2012), ISBN 978-3-8325-3121-8, pp. 8 (). Based on their structure, the compounds can be divided into nume ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
