Cliteromegaly
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Clitoromegaly (or macroclitoris) is an abnormal enlargement of the
clitoris In amniotes, the clitoris ( or ; : clitorises or clitorides) is a female sex organ. In humans, it is the vulva's most erogenous zone, erogenous area and generally the primary anatomical source of female Human sexuality, sexual pleasure. Th ...
that is mostly
congenital A birth defect is an abnormal condition that is present at childbirth, birth, regardless of its cause. Birth defects may result in disability, disabilities that may be physical disability, physical, intellectual disability, intellectual, or dev ...
; it is otherwise acquired through deliberately induced
clitoral enlargement In amniotes, the clitoris ( or ; : clitorises or clitorides) is a female sex organ. In humans, it is the vulva's most erogenous area and generally the primary anatomical source of female sexual pleasure. The clitoris is a complex structu ...
, a form of
body modification Body modification (or body alteration) is the deliberate altering of the human anatomy or human physical appearance. In its broadest definition it includes skin tattooing, socially acceptable decoration (''e.g.'', common earring, ear piercing in ...
, by use of anabolic steroids, in particular
testosterone Testosterone is the primary male sex hormone and androgen in Male, males. In humans, testosterone plays a key role in the development of Male reproductive system, male reproductive tissues such as testicles and prostate, as well as promoting se ...
. It can happen as part of a
gender transition Gender transition is the process of affirming and expressing one's internal sense of gender, rather than the sex assigned to them at birth. It is a recommended course of treatment for individuals experiencing gender dysphoria, providing impro ...
. It is clinically distinguishable from normal enlargement of the clitoris seen during
sexual arousal Sexual arousal (also known as sexual excitement) describes the Physiology, physiological and psychological responses in preparation for sexual intercourse or when exposed to Sexual stimulation, sexual stimuli. A number of physiological response ...
.


Presentation

Degree of genital ambiguity is commonly measured by the Prader classification, which ranges, in ascending order of masculinisation, from 1: ''female external genitalia with clitoromegaly'' through 5: ''pseudo-phallus looking like normal male external genitalia''.


Causes

Clitoromegaly is a rare condition and can be either present by birth or acquired later in life. If present at birth,
congenital adrenal hyperplasia Congenital adrenal hyperplasia (CAH) is a group of Genetic disorder#Autosomal recessive, autosomal recessive disorders characterized by impaired cortisol synthesis. It results from the deficiency of one of the five enzymes required for the Biosy ...
can be one of the causes, since in this condition the adrenal gland of the female fetus produces additional androgens and the newborn baby has ambiguous genitalia which are not clearly male or female. In pregnant women who received
norethisterone Norethisterone, also known as norethindrone and sold under the brand name Norlutin among others, is a progestin medication used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders. The medicatio ...
during pregnancy, masculinization of the fetus occurs, resulting in hypertrophy of the clitoris; however, this is rarely seen nowadays due to use of safer
progestogens Progestogens, also sometimes written progestins, progestagens or gestagens, are a class of natural or synthetic steroid hormones that bind to and activate the progesterone receptors (PR). Progesterone is the major and most important progestogen ...
. It can also be caused by the
autosomal An autosome is any chromosome that is not a sex chromosome. The members of an autosome pair in a diploid cell have the same morphology, unlike those in allosomal (sex chromosome) pairs, which may have different structures. The DNA in autosome ...
recessive In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome. The first variant is termed dominant and ...
congenital disorder known as
Fraser syndrome Fraser syndrome (also known as Meyer-Schwickerath's syndrome, Fraser-François syndrome, or Ullrich-Feichtiger syndrome) is an autosomal recessive congenital disorder, identified by several developmental anomalies. Fraser syndrome is named for th ...
. In acquired clitoromegaly, the main cause is endocrine hormonal imbalance affecting the adult person, including polycystic ovarian syndrome (PCOS) and
hyperthecosis Hyperthecosis, or ovarian hyperthecosis, is hyperplasia of the theca interna of the ovary. Hyperthecosis occurs when an area of luteinization occurs along with stromal hyperplasia. The luteinized cells produce androgens, which may lead to hirsuti ...
. Acquired clitoromegaly may also be caused by pathologies affecting the ovaries and other
endocrine gland The endocrine system is a network of glands and organs located throughout the body. Along with the nervous system, it makes the neuroendocrine system, which controls and regulates many of the body's functions. Endocrine glands are ductless gland ...
s. These pathologies may include virulent (such as arrhenoblastoma) and neurofibromatosic tumors. Another cause is clitoral cysts. Sometimes there may be no obvious clinical or hormonal reason. Female bodybuilders and athletes who use
androgens An androgen (from Greek ''andr-'', the stem of the word meaning ) is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This includes ...
, primarily to enhance muscular growth, strength and appearance, may also experience clearly evident enlargement of the clitoris and increases in
libido In psychology, libido (; ) is psychic drive or energy, usually conceived of as sexual in nature, but sometimes conceived of as including other forms of desire. The term ''libido'' was originally developed by Sigmund Freud, the pioneering origin ...
. Women who use testosterone for therapeutic reasons (treating low libido, averting
osteoporosis Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to more porous bone, and consequent increase in Bone fracture, fracture risk. It is the most common reason f ...
, as part of an anti-depressant regimen, etc.) may experience some enlargement of the clitoris, although the dosages warranted for these conditions are much lower.


Anatomy

In ''Atlas of Human Sex Anatomy'' (1949) by
Robert Latou Dickinson Robert Latou Dickinson (February 21, 1861 – November 29, 1950) was an American obstetrician and gynecologist, surgeon, maternal health educator, artist, sculptor and medical illustrator, research scientist, author, and public health educator. ...
, the ''typical'' clitoris is defined as having a crosswise measurement of 3 to 4 mm (0.12 - 0.16 inches) and a lengthwise measurement of 4 to 5 mm (0.16 - 0.20 inches). On the other hand, in obstetrics and gynecology medical literature, a frequent definition of clitoromegaly is when there is a clitoral index (product of lengthwise and crosswise measurements) of greater than 35 mm2 (0.05 inches2), which is almost twice the size given above for an ''average'' sized clitoris.


Human rights concerns

Early surgical reduction of clitoromegaly via full or partial
clitoridectomy Clitoridectomy or clitorectomy is the surgical removal, reduction, or partial removal of the clitoris. It is rarely used as a therapeutic medical procedure, such as when cancer has developed in or spread to the clitoris. Commonly, non-medical rem ...
is controversial, as many that have undergone such treatment have spoken of their loss of physical sensation, and loss of autonomy. In recent years, human rights institutions have criticized early surgical management of such characteristics. In 2013, it was disclosed in a medical journal that four unnamed elite female athletes from developing countries were required to receive gonadectomies and partial clitoridectomies if they wanted to continue competing after testosterone testing revealed that they had
5α-Reductase 2 deficiency 5α-Reductase 2 deficiency (5αR2D) is an autosomal recessive condition caused by mutations impairing the function of ''SRD5A2'', a gene located on chromosome 2 and encoding the enzyme 5α-reductase type 2 (5αR2). 5αR2 is expressed in specific ...
. In April 2016, the
United Nations Special Rapporteur Special rapporteur (or independent expert) is the title given to independent human rights experts whose expertise is called upon by the United Nations (UN) to report or advise on human rights from a thematic or country-specific perspective. De ...
on health, Dainius Pūras, condemned this treatment as a form of
female genital mutilation Female genital mutilation (FGM) (also known as female genital cutting, female genital mutilation/cutting (FGM/C) and female circumcision) is the cutting or removal of some or all of the vulva for non-medical reasons. Prevalence of female ge ...
"in the absence of symptoms or health issues warranting those procedures."


See also

*
Micropenis A micropenis or microphallus is an unusually small Human penis, penis. A common criterion is a dorsal (measured on top) Human penis size, penile length of at least 2.5 standard deviations smaller than the mean human penis size for age. A micr ...
*
Pseudo-penis A pseudo-penis is any structure found on an animal that, while superficially appearing to be a penis, is derived from a different developmental path. Mammals In mammals, all intact developmentally typical males have a penis, but the clitoris i ...
, an enlarged clitoris or other penis-like structure that is normally present in some mammal, bird, and insect species


References


External links

{{Congenital malformations of genital organs and urinary system Congenital disorders of female genital organs Megaly Intersex variations