Cell Signaling Technology, Inc. (CST) is a privately held company that develops and produces

antibodies An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...

, ELISA kits, ChIP kits, proteomic kits, and other related reagents used to study the cell signaling pathways that impact human health. CST maintains an in-house research program, particularly in the area of cancer research, and has published scientific papers in many peer-reviewed journals.

History

Cell Signaling Technology was founded in 1999 by scientists in the Cell Signaling group at New England Biolabs (NEB).A lab with a view: New research space reflects company's open, research-driven philosophy
/ref> Originally housed in the Cummings Center (

Beverly, Massachusetts Beverly is a city in Essex County, Massachusetts, and a suburb of Boston. The population was 42,670 at the time of the 2020 United States Census. A resort, residential, and manufacturing community on the Massachusetts North Shore, Beverly incl ...

), CST moved to its current United States headquarters located at the former King’s Grant Inn (

Danvers, Massachusetts Danvers is a town in Essex County, Massachusetts, United States, located on the Danvers River near the northeastern coast of Massachusetts. The suburb is a fairly short ride from Boston and is also in close proximity to the renowned beaches of Glo ...

) in late 2005. Following extensive renovation, the U.S. Green Building Council has certified the current headquarters as a LEED (Leadership in Energy and Environmental Design) certified facility in 2007. In 2008 and 2009, CST expanded its overseas operations, establishing subsidiary offices in the People’s Republic of China,

Japan Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north ...

, and the Netherlands.Cell Signaling Technology buys Dutch distributor
/ref> In 2013, CST moved its production group into an ISO9001 certified facility in Beverly, Massachusetts. Cell Signaling Technology was named as one of the “Top 100 Places to Work” in a 2009-2013 survey published by the Boston Globe.Globe Top 100 Places to Work
/ref>

Research

In addition to product development and production, CST is also involved in the development of new technologies for signaling analysis as well as mechanistic cell biology research, particularly in the field of cancer research. CST curates and maintains PhosphoSitePlus, a web-based bioinformatics resource that details post-translational modifications (PTMs) in human, mouse and rat proteins. The types of PTMs curated include phosphorylation, acetylation, methylation, ubiquitylation, glycosylation, etc. This freely accessible, online resource is funded in part through grant support from the NIH, and most recently through the NIH BD2K initiative.

Notable employees

* Klarisa Rikova

References

External links

Cell Signaling Technology, Inc. web site

PhosphoSitePlus web site
{{Authority control Biotechnology companies established in 1999 Companies based in Beverly, Massachusetts Biotechnology companies of the United States Life science companies based in Massachusetts Research support companies 1999 establishments in Massachusetts Companies based in Danvers, Massachusetts Privately held companies of the United States American companies established in 1999