The transmembrane cation channel superfamily was defined in
InterPro
InterPro is a database of protein families, protein domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences in order to functionally characterise them.
The contents of InterPro ...
and
Pfam
Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models. The latest version of Pfam, 37.0, was released in June 2024 and contains 21,979 families. It is cur ...
as the family of
tetrameric
A tetramer () (''tetra-'', "four" + '' -mer'', "parts") is an oligomer formed from four monomers or subunits. The associated property is called ''tetramery''. An example from inorganic chemistry is titanium methoxide with the empirical formula Ti ...
ion channels
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ...
. These include the
sodium
Sodium is a chemical element; it has Symbol (chemistry), symbol Na (from Neo-Latin ) and atomic number 11. It is a soft, silvery-white, highly reactive metal. Sodium is an alkali metal, being in group 1 element, group 1 of the peri ...
,
potassium
Potassium is a chemical element; it has Symbol (chemistry), symbol K (from Neo-Latin ) and atomic number19. It is a silvery white metal that is soft enough to easily cut with a knife. Potassium metal reacts rapidly with atmospheric oxygen to ...
,
calcium
Calcium is a chemical element; it has symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar to it ...
,
ryanodine receptor
Ryanodine receptors (RyR) make up a class of high-conductance, intracellular calcium channels present in various forms, such as animal muscles and neurons. There are three major isoforms of the ryanodine receptor, which are found in different tissu ...
,
HCN,
CNG
Compressed natural gas (CNG) is a fuel gas mainly composed of methane (CH4), compressed to less than 1% of the volume it occupies at standard atmospheric pressure. It is stored and distributed in hard containers at a pressure of , usually in c ...
,
CatSper
The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels tha ...
, and
TRP channels. This large group of ion channels apparently includes families , , , and of the
TCDB transporter classification.
They are described as minimally having two
transmembrane helices flanking a loop which determines the
ion selectivity of the channel pore. Many eukaryotic channels have four additional transmembrane helices (TM) (), related to or
vestigial
Vestigiality is the retention, during the process of evolution, of genetically determined structures or attributes that have lost some or all of the ancestral function in a given species. Assessment of the vestigiality must generally rely on co ...
of
voltage gating. The proteins with only two transmembrane helices () are most commonly found in bacteria. This also includes the 2-TM
inward-rectifier potassium channel
Inward-rectifier potassium channels (Kir, IRK) are a specific Lipid-gated_ion_channels, lipid-gated subset of potassium channels. To date, seven subfamilies have been identified in various mammalian cell types, plants, and bacteria. They are acti ...
s () found primarily in eukaryotes. There are commonly additional regulatory domains which serve to regulate ion conduction and channel gating. The pores may also be
homotetramer
A tetrameric protein is a protein with a quaternary structure of four subunits (tetrameric). Homotetramers have four identical subunits (such as glutathione S-transferase), and heterotetramers are complexes of different subunits. A tetramer ...
s or
heterotetramer
A tetrameric protein is a protein with a quaternary structure of four subunits (tetrameric). Homotetramers have four identical subunits (such as glutathione S-transferase), and heterotetramers are complexes of different subunits. A tetrame ...
s; where heterotetramers may be encoded as distinct genes or as multiple pore domains within a single polypeptide. The
HVCN1 and
Putative tyrosine-protein phosphatase proteins do not contain an expected ion conduction pore domain, but rather have homology only to the voltage sensor domain of
voltage gated ion channels.
Human channels with 6 TM helices
Cation
Transient receptor potential
= Canonical
=
*
TRPC1
Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the ''TRPC1'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of n ...
;
TRPC3
Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The TRPC3/6/7 subfamily are implicated in the regulation of vascular tone, cell grow ...
;
TRPC4
The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the ''TRPC4'' gene.
Function
TrpC4 is a member of the transient receptor potential cation channels. This ...
;
TRPC5
Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the ''TRPC5'' gene. TrpC5 is subtype of the TRPC family of mammalian transient receptor potential io ...
;
TRPC6
Transient receptor potential cation channel, subfamily C, member 6 or Transient receptor potential canonical 6, also known as TRPC6, is a protein encoded in the human by the ''TRPC6'' gene. TRPC6 is a transient receptor potential channel of the c ...
;
TRPC7
= Melastatin
=
*
TRPM1
Transient receptor potential cation channel subfamily M member 1 is a protein that in humans is encoded by the ''TRPM1'' gene.
Function
The protein encoded by this gene is a member of the transient receptor potential (TRP) family of non-select ...
;
TRPM2
Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the ''TRPM2'' gene.
Structure
The protein encoded by this gene is a non-selective calcium-permeable cation channe ...
;
TRPM3
Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the ''TRPM3'' gene.
Function
The product of this gene belongs to the family of Transient receptor potential channel, transient receptor ...
;
TRPM4
Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene. TRPM4 Channel Blocker
* 9-Phenanthrol
* TRPM4-IN-5
See also
* TRPM
TRPM is a family ...
;
TRPM5
Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the ''TRPM5'' gene.
Function
TRPM5 is a calcium-activated non-select ...
;
TRPM6;
TRPM7
Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.
Function
TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are i ...
;
TRPM8
Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the ''TRPM8'' gene. The TRPM8 channel is the primary molecular ...
= Vanilloid
=
*
TRPV1
The transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the ''TRPV1'' gene. It was the first isolated member of ...
;
TRPV2
Transient receptor potential cation channel subfamily V member 2 is a protein that in humans is encoded by the ''TRPV2'' gene. TRPV2 is a nonspecific cation channel that is a part of the TRP channel family. This channel allows the cell to communi ...
;
TRPV3
Transient receptor potential cation channel, subfamily V, member 3, also known as TRPV3, is a human gene encoding the protein of the same name.
The TRPV3 protein belongs to a family of nonselective cation channels that function in a variety of p ...
;
TRPV4
Transient receptor potential cation channel subfamily V member 4 is an ion channel protein that in humans is encoded by the ''TRPV4'' gene.
The ''TRPV4'' gene encodes TRPV4, initially named "vanilloid-receptor related osmotically activated chann ...
;
TRPV5
Transient receptor potential cation channel subfamily V member 5 is a calcium channel protein that in humans is encoded by the ''TRPV5'' gene.
Function
The ''TRPV5'' gene is a member of the transient receptor family and the TRPV subfamily. Th ...
;
TRPV6
TRPV6 is a membrane calcium (Ca2+) channel protein which is particularly involved in the first step in Ca2+absorption in the intestine.
Classification
Transient Receptor Potential Vanilloid subfamily member 6 (TRPV6) is an epithelial Ca2+ ...
= Mucolipin
=
*
MCOLN1
Mucolipin-1 (ML1) also known as TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) is a protein that in humans is encoded by the ''MCOLN1'' gene. It is a member of the small family of the TRPML channels, a subgro ...
;
MCOLN2;
MCOLN3
Mucolipin-3 also known as TRPML3 (transient receptor potential cation channel, mucolipin subfamily, member 3) is a protein that in humans is encoded by the ''MCOLN3'' gene. It is a member of the small family of the TRPML channels, a subgroup of ...
;
= Ankyrin
=
*
TRPA1
Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1, TRPA1, or The Mustard and Wasabi Receptor, is a protein that in humans is encoded by the ''TRPA1'' (and in mice and rats by ...
= TRPP
=
*
PKD1L3;
Calcium
Voltage-dependent
*
CACNA1A;
CACNA1B
The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a s ...
;
CACNA1C;
CACNA1D;
CACNA1E;
CACNA1F
Cav1.4 also known as the calcium channel, voltage-dependent, L type, alpha 1F subunit (CACNA1F), is a human gene.
This gene encodes a member of the alpha-1 subunit family; a protein in the voltage-dependent calcium channel complex. Calcium chan ...
;
CACNA1G
Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Cav3.1 is a protein which in humans is encoded by the ''CACNA1G'' gene. It is one of the primary targets in the pharmacology of absence seizure.
Function
Ca ...
;
CACNA1H
Calcium channel, voltage-dependent, T type, alpha 1H subunit, also known as CACNA1H, is a protein which in humans is encoded by the ''CACNA1H'' gene.
Function
This gene encodes Cav3.2, a T-type member of the α1 subunit family, a protein in t ...
;
CACNA1I
Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3 is a protein which in humans is encoded by the ''CACNA1I'' gene.
Function
Voltage-dependent calcium channels can be distinguished based on their volt ...
;
CACNA1S
Sperm
*
CATSPER1;
CATSPER2;
CATSPER3;
CATSPER4
Ryanodine receptor
*
RYR1
Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is one of a class of ryanodine receptors and a protein found primarily in skeletal muscle. In humans, it is encoded by th ...
;
RYR2
Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the ''RYR2'' gene. In the process of cardiac calcium-induced calcium release, RYR2 is the major med ...
;
RYR3
Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the ''RYR3'' gene. The protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 and ...
Potassium
Voltage-gated potassium
= Delayed rectifier
=
*K
vα1.x -
Shaker-related: K
v1.1 (
KCNA1), K
v1.2 (
KCNA2
Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the ''KCNA2'' gene.
Function
Potassium channels represent the most complex class of voltage-gated ion channels from both functio ...
), K
v1.3 (
KCNA3
Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans is encoded by the ''KCNA3'' gene.
Potassium channels represent the most complex class of voltage-gated ion channels f ...
), K
v1.5 (
KCNA5
Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans is encoded by the ''KCNA5'' gene.
Function
Potassium channels represent the most complex class of voltage-gated ion ...
), K
v1.6 (
KCNA6
Potassium voltage-gated channel subfamily A member 6 also known as Kv1.6 is a protein that in humans is encoded by the ''KCNA6'' gene. The protein encoded by this gene is a voltage-gated potassium channel
Voltage-gated potassium channels (V ...
), K
v1.7 (
KCNA7), K
v1.8 (
KCNA10)
*K
vα2.x - Shab-related: K
v2.1 (
KCNB1
Potassium voltage-gated channel, Shab-related subfamily, member 1, also known as KCNB1 or Kv2.1, is a protein that, in humans, is encoded by the ''KCNB1'' gene.
Potassium voltage-gated channel subfamily B member one, or simply known as KCNB1, i ...
), K
v2.2 (
KCNB2)
*K
vα3.x - Shaw-related: K
v3.1 (
KCNC1), K
v3.2 (
KCNC2
Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the ''KCNC2'' gene. The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).
Expression pattern
Kv3.1 and Kv3.2 channel ...
)
*K
vα7.x: K
v7.1 (
KCNQ1
Kv7.1 (KvLQT1) is a potassium channel protein whose primary subunit in humans is encoded by the ''KCNQ1'' gene. Its mutation causes Long QT syndrome, Kv7.1 is a voltage and lipid-gated potassium channel present in the cell membranes of cardi ...
) -
KvLQT1
Kv7.1 (KvLQT1) is a potassium ion channel, channel protein whose primary subunit in humans is encoded by the ''KCNQ1'' gene. Its mutation causes Long QT syndrome, Kv7.1 is a voltage and Lipid-gated ion channels, lipid-gated potassium channel pr ...
, K
v7.2 (
KCNQ2
Kv7.2 (KvLQT2) is a voltage- and lipid-gated potassium channel protein coded for by the gene KCNQ2.
Mutations in the KCNQ2 gene are dominant autosomally inherited causes of benign familial neonatal epilepsy.
Function
The M channel is a slo ...
), K
v7.3 (
KCNQ3
Kv7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.
It is associated with benign familial neonatal epilepsy.
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regula ...
), K
v7.4 (
KCNQ4
Potassium voltage-gated channel subfamily KQT member 4, also known as voltage-gated potassium channel subunit Kv7.4, is a protein that in humans is encoded by the ''KCNQ4'' gene.
Function
The protein encoded by this gene forms a potassium chan ...
), K
v7.5 (
KCNQ5
Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the ''KCNQ5'' gene.
This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and i ...
)
*K
vα10.x: K
v10.1 (
KCNH1
Potassium voltage-gated channel subfamily H member 1 (KV10.1, EAG1) is a protein that in humans is encoded by the ''KCNH1'' gene. Mutations in ''KCNH1'' cause genetic epilepsy and developmental encephalopathies, and aberant expression is associat ...
)
= A-type potassium
=
*K
vα1.x - Shaker-related: K
v1.4 (
KCNA4
Potassium voltage-gated channel subfamily A member 4 also known as Kv1.4 is a protein that in humans is encoded by the ''KCNA4'' gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the ...
)
*K
vα3.x - Shaw-related: K
v3.3 (
KCNC3), K
v3.4 (
KCNC4)
*K
vα4.x - Shal-related: K
v4.1 (
KCND1
Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as Kv4.1, is a human gene.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structu ...
), K
v4.2 (
KCND2
Potassium voltage-gated channel subfamily D member 2 is a protein that in humans is encoded by the ''KCND2'' gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase ...
), K
v4.3 (
KCND3
Potassium voltage-gated channel subfamily D member 3 also known as Kv4.3 is a protein that in humans is encoded by the ''KCND3'' gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the ...
)
= Outward-rectifying
=
*K
vα10.x: K
v10.2 (
KCNH5
Potassium voltage-gated channel, subfamily H (eag-related), member 5, also known as KCNH5, is a human gene encoding the Kv10.2 protein.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both ...
)
= Inwardly-rectifying
=
*K
vα11.x -
ether-a-go-go potassium channels: K
v11.1 (
KCNH2
hERG (the human '' Ether-à-go-go''-Related Gene) is a gene () that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution t ...
) -
hERG
hERG (the human '' Ether-à-go-go''-Related Gene) is a gene () that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution t ...
, K
v11.2 (
KCNH6
Potassium voltage-gated channel subfamily H member 6 is a protein that in humans is encoded by the ''KCNH6'' gene. The protein encoded by this gene is a voltage-gated potassium channel
Voltage-gated potassium channels (VGKCs) are potassium ...
), K
v11.3 (
KCNH7
Potassium voltage-gated channel subfamily H member 7 is a protein that in humans is encoded by the ''KCNH7'' gene. The protein encoded by this gene is a voltage-gated potassium channel
Voltage-gated potassium channels (VGKCs) are potassium ...
)
= Slowly activating
=
*K
vα12.x: K
v12.1 (
KCNH8
Potassium voltage-gated channel subfamily H member 8 is a protein that in humans is encoded by the ''KCNH8'' gene. The protein encoded by this gene is a voltage-gated potassium channel
Voltage-gated potassium channels (VGKCs) are potassium ...
), K
v12.2 (
KCNH3), K
v12.3 (
KCNH4
Potassium voltage-gated channel subfamily H member 4 is a protein, that in humans, is encoded by the ''KCNH4'' gene. The protein encoded by this gene is a voltage-gated potassium channel
Voltage-gated potassium channels (VGKCs) are potassiu ...
)
= Modifier/silencer
=
*K
vα5.x: K
v5.1 (
KCNF1
Potassium voltage-gated channel subfamily F member 1 is a protein that in humans is encoded by the ''KCNF1'' gene. The protein encoded by this gene is a voltage-gated potassium channel
Voltage-gated potassium channels (VGKCs) are potassium ...
)
*K
vα6.x: K
v6.1 (
KCNG1), K
v6.2 (
KCNG2), K
v6.3 (
KCNG3
Potassium voltage-gated channel subfamily G member 3 is a protein that in humans is encoded by the ''KCNG3'' gene. The protein encoded by this gene is a voltage-gated potassium channel
Voltage-gated potassium channels (VGKCs) are potassium ...
), K
v6.4 (
KCNG4)
*K
vα8.x: K
v8.1 (
KCNV1), K
v8.2 (
KCNV2)
*K
vα9.x: K
v9.1 (
KCNS1
Potassium voltage-gated channel subfamily S member 1 is a protein that in humans is encoded by the ''KCNS1'' gene. The protein encoded by this gene is a voltage-gated potassium channel
Voltage-gated potassium channels (VGKCs) are potassium ...
), K
v9.2 (
KCNS2), K
v9.3 (
KCNS3)
Calcium-activated
= BK
=
*
KCa1.1 (BK, Slo1, Maxi-K, )
= SK
=
* K
Ca2.x: K
Ca2.1 (
KCNN1
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 , also known as KCNN1 is a human gene encoding the KCa2.1 protein.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) t ...
) - SK1, K
Ca2.2 (
KCNN2
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, also known as KCNN2, is a protein which in humans is encoded by the KCNN2 gene. KCNN2 is an ion channel protein also known as KCa2.2.
Function
Action p ...
) - SK2, K
Ca2.3 (
KCNN3) - SK3
* K
Ca3.x: K
Ca3.1 (
KCNN4
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.
Function
The KCa3.1 protein is part of a potentially heterotetrameric voltage-independ ...
) - SK4
* K
Ca4.x: K
Ca4.1 (
KCNT1
Potassium channel subfamily T, member 1, also known as KCNT1 or SLACK is a human gene that encodes the KCa4.1 protein. KCa4.1 is a member of the calcium-activated potassium channel protein family
Associated Conditions
Mutations in the KCNT1 ge ...
) - SLACK, K
Ca4.2 (
KCNT2
Potassium channel subfamily T, member 2, also known as KCNT2 is a human gene that encodes the KNa protein. KCNT2, also known as the Slick channel (sequence like an intermediate calcium channel) is an outwardly rectifying potassium channel activat ...
) - SLICK
= IK
=
*
KCa3.1 (IKCa1, SK4, )
= Other subfamilies
=
*
KCa5.1 (Slo3, )
Inward-rectifier potassium
Sodium
*
NALCN
*
SCN1A
Sodium channel protein type 1 subunit alpha (SCN1A), is a protein which in humans is encoded by the ''SCN1A'' gene.
Gene location
The ''SCN1A'' gene is located on chromosome 2 of humans, and is made up of 26 exons spanning a total length of 6 ...
;
SCN2A;
SCN2A2;
SCN3A
Sodium channel, voltage-gated, type III, alpha subunit (SCN3A) is a protein that in humans is encoded by the ''SCN3A'' gene.
Function
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit wi ...
;
SCN4A
Sodium channel protein type 4 subunit alpha is a protein that in humans is encoded by the ''SCN4A'' gene.
The Nav1.4 voltage-gated sodium channel is encoded by the gene. Mutations in the gene are associated with hypokalemic periodic paralysis ...
;
SCN5A
Sodium channel protein type 5 subunit alpha, also known as NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. NaV1.5 is found primarily in cardiac muscle, where it mediates the fast influx of ...
;
SCN7A;
SCN8A
Sodium channel protein type 8 subunit alpha also known as Nav1.6 is a membrane protein encoded by the ''SCN8A'' gene. Nav1.6 is one sodium channel isoform and is the primary voltage-gated sodium channel at each node of Ranvier. The channels are h ...
;
SCN9A
Sodium voltage-gated channel alpha subunit 9 (also Nav1.7) is a sodium ion channel that, in humans, is encoded by the ''SCN9A'' gene. It is usually expressed at high levels in two types of neurons: the nociceptive (pain) neurons at the dorsal ...
;
SCN10A
Nav1.8 is a sodium ion channel subtype that in humans is encoded by the ''SCN10A'' gene.
Nav1.8-containing channels are tetrodotoxin (TTX)-resistant voltage-gated channels. Nav1.8 is expressed specifically in the dorsal root ganglion (DRG), in ...
;
SCN11A
Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Nav1.9 is a voltage-gated ion channel, voltage-gated sodium ion channel protein which is encoded by the ''SCN11A'' gene on Chromosome 3 (human), chromosome 3 in human ...
*
SLC9A10;
SLC9A11
Cyclic nucleotide-gated
*
CNGA1;
CNGA2;
CNGA3;
CNGA4
*
CNGB1;
CNGB3
*
HCN1;
HCN2;
HCN3
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the ''HCN3'' gene.
See also
* Cyclic nucleotide-gated ion channel
Cycle, cycles, or cyclic may refer to:
Anthropology a ...
;
HCN4
*
ITPR1
Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ''ITPR1'' gene.
Interactions
ITPR1 has been shown to interact with:
* AHCYL1,
* CA8,
* EPB41L1
* FKBP1A,
* MRVI1,
* PRKG1,
* RHOA
Tran ...
;
ITPR2
Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ''ITPR2'' gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel
A calcium ...
;
ITPR3
Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ''ITPR3'' gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.
Function
...
Proton
*
HVCN1
Related proteins
*
TPTE
Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the ''TPTE'' gene.
Function
TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of i ...
, part of the larger
Voltage sensitive phosphatase
Voltage sensitive phosphatases or voltage sensor-containing phosphatases, commonly abbreviated VSPs, are a protein family found in many species, including humans, mice, zebrafish, frogs, and sea squirt.
Discovery
The first voltage sensitive phos ...
family
Human channels with 2 TM helices in each subunit
Potassium
Tandem pore domain potassium channel
*
KCNK1;
KCNK2
Potassium channel subfamily K member 2, also known as TREK-1, is a protein that in humans is encoded by the ''KCNK2'' gene.
This gene encodes K2P2.1, a lipid-gated ion channel belonging to the two-pore-domain background potassium channel protei ...
;
KCNK3
Potassium channel subfamily K member 3 is a protein that in humans is encoded by the ''KCNK3'' gene.
This gene encodes K2P3.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P3.1 is an ...
;
KCNK4;
KCNK5;
KCNK6;
KCNK7;
KCNK9;
KCNK10;
KCNK12;
KCNK13;
KCNK15;
KCNK16;
KCNK17;
KCNK18
Non-human channels
Two-pore
*
TPCN1
*
TPCN2
Pore-only potassium
*
KcsA
Ligand-gated potassium
* GluR0
Voltage-gated potassium
* KvAP
Prokaryotic KCa
* Kch
* MthK
* TrkA/TrkH
* KtrAB
* GsuK
* TM1088
Voltage and cyclic nucleotide gated potassium
* MlotiK1
Sodium
* NaChBac
* NaVAb
* NaVAe1
* NaVAp
* NaVMm
Non-selective
* NaK
Prokaryotic inward-rectifier potassium
* KirBac
Engineered
* NaK2CNG
* NaK2K
References
External links
*
{{InterPro content, IPR005821
Protein domains
Protein families
Transmembrane proteins
Ion channels