Cannabigerolic acid (CBGA) is the acidic form of cannabigerol (CBG). It is a dihydroxybenzoic acid and olivetolic acid in which the hydrogen at position 3 is substituted by a geranyl group. It is a biosynthetic precursor to Delta-9-tetrahydrocannabinol, which is the principal psychoactive constituent of the ''

Cannabis ''Cannabis'' () is a genus of flowering plants in the family Cannabaceae that is widely accepted as being indigenous to and originating from the continent of Asia. However, the number of species is disputed, with as many as three species be ...

'' plant. It is also a meroterpenoid (i.e. a

polyketide In organic chemistry, polyketides are a class of natural products derived from a Precursor (chemistry), precursor molecule consisting of a Polymer backbone, chain of alternating ketone (, or Carbonyl reduction, its reduced forms) and Methylene gro ...

and a

terpenoid The terpenoids, also known as isoprenoids, are a class of naturally occurring organic compound, organic chemicals derived from the 5-carbon compound isoprene and its derivatives called terpenes, diterpenes, etc. While sometimes used interchangeabl ...

), a member of resorcinols and a

phytocannabinoid Cannabinoids () are several structural classes of compounds found primarily in the ''Cannabis'' plant or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary psychoac ...

. It derives from an olivetolic acid. It is a conjugate acid of a cannabigerolate. In the ''Cannabis'' plant, olivetolic acid and

geranyl diphosphate Geranyl pyrophosphate (GPP), also known as geranyl diphosphate (GDP), is the pyrophosphate ester of the terpenoid geraniol. Its salts are colorless. It is a precursor to many thousands of natural products. Occurrence GPP is an intermediate in the ...

are synthesized into CBGA. CBGA is converted in the plant by CBCA synthase, CBDA synthase and THCA synthase into CBCA,

CBDA Cannabidiolic acid (CBDA), is a cannabinoid produced in cannabis plants. It is the Chemical precursor, precursor to cannabidiol (CBD). It is most abundant in the glandular trichomes on the female seedless flowers or more accurately infructescence ...

and THCA respectively.

References

{{Transient receptor potential channel modulators Cannabinoids Terpeno-phenolic compounds Transient receptor potential channel modulators