The Cancer Diagnostic Probe (CDP) is a medical device used in Iran during

breast cancer Breast cancer is a cancer that develops from breast tissue. Signs of breast cancer may include a Breast lump, lump in the breast, a change in breast shape, dimpling of the skin, Milk-rejection sign, milk rejection, fluid coming from the nipp ...

surgery. First developed by Nano Hesgar Sazan Salamt Arya, an

Iran Iran, officially the Islamic Republic of Iran (IRI) and also known as Persia, is a country in West Asia. It borders Iraq to the west, Turkey, Azerbaijan, and Armenia to the northwest, the Caspian Sea to the north, Turkmenistan to the nort ...

ian company, CDP has received medical approval in Iran, where it is used in surgical centers.

Development and application

The Cancer Diagnostic Probe was developed by a team led by Mohammad Abdolahad, a 2019

Mustafa Prize The Mustafa Prize is a science and technology award, granted to top researchers and scientists from the Organisation of Islamic Cooperation (OIC) member states. The prize is granted to scholars of the Islamic world as one of the symbols of scienti ...

laureate and faculty member of the School of Electrical and Computer Engineering at the

University of Tehran The University of Tehran (UT) or Tehran University (, ) is a public collegiate university in Iran, and the oldest and most prominent Iranian university located in Tehran. Based on its historical, socio-cultural, and political pedigree, as well as ...

, to facilitate the determination of cancerous

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s. Abdolahad stated that the clinical trial for the device lasted 4 years and that up to 500 surgeries had been carried out using the CDP by 2020. According to Sayyed Ruhollah Miri, the head of the Cancer Institute at the

Tehran University of Medical Sciences Tehran University of Medical Sciences (TUMS) (, ''Danushgah-e 'lum Pezeshki-ye Tehran'') is the largest and most highly ranked medical university of Iran. In September 2008, Iran's Minister of Health, Treatment, and Medical Education, Lankarani ...

, the CDP reduces the diagnosis time to 1–2 minutes.

Mechanism

The CDP device is composed of three main parts: "a disposable sensor; a wireless electrical head probe used by the surgeon; nda main control computer system which receives the signals from the head probe". It electrochemically measures the hypoxia glycolysis

metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...

in real-time "in pre-cancerous and cancerous lesions in cavity side margins". It measures the release of H₂O₂ from cancer or atypical cells by the reverse Warburg effect.

Reception

The development of CDP was supported by the Iranian Nano Technology Development Headquarters. After receiving medical approval, this system has been used in breast cancer surgeries in Iran. , four U.S. patents have been

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related to CDP.

References

{{reflist, 30em Iranian inventions Breast cancer Medical devices Medical research in Asia