Calyculins are natural products originally isolated from the marine sponge '' Discodermia calyx.'' Calyculins have proven to be strong serine/threonine protein phosphatase inhibitors and based on this property, calyculins might be potential tumor-promoting agents. A laboratory synthesis of calyculin A has been reported.

Biosynthesis

Calyculin A is biosynthesized as a pyrophosphate containing phosphocalyculin A protoxins by a hybrid PKS-NRPS pathway within the sponge bacterial symbiont, "''Candidatus'' Entotheonella" sp.

References

Organophosphates Nitriles Spiro compounds {{Oncology-stub