Calbindin 1 is a
protein that in humans is encoded by the ''CALB1''
gene. It belongs to the
calbindin family of
calcium-binding proteins, along with
calretinin (''CALB2'').
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]
Function
The protein encoded by this gene is a member of the
calcium-binding protein superfamily that includes
calmodulin
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the bind ...
and
troponin C. Originally described as a 27 kDa protein, it is now known to be a 28
kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability.
This protein is thought to buffer entry of calcium upon stimulation of
glutamate receptors. Depletion of this protein was noted in patients with
Huntington disease.
rovided by RefSeq, Jan 2015
References
Further reading
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