CYB003, or CYB-003, also known as deuterated psilocybin analogue, is a

serotonergic psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluci ...

related to

psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...

which is under development for the treatment of

major depressive disorder Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive depression (mood), low mood, low self-esteem, and anhedonia, loss of interest or pleasure in normally ...

alcoholism Alcoholism is the continued drinking of alcohol despite it causing problems. Some definitions require evidence of dependence and withdrawal. Problematic use of alcohol has been mentioned in the earliest historical records. The World He ...

, and other

psychiatric disorder A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. A mental disorder is ...

s. It is taken

by mouth Oral administration is a route of administration whereby a substance is taken through the Human mouth, mouth, swallowed, and then processed via the digestive system. This is a common route of administration for many medications. Oral administ ...

. It is a

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the firs ...

derivative In mathematics, the derivative is a fundamental tool that quantifies the sensitivity to change of a function's output with respect to its input. The derivative of a function of a single variable at a chosen input value, when it exists, is t ...

and is a deuterated analogue of

and

psilocin Psilocin, also known as 4-hydroxy-''N'',''N''-dimethyltryptamine (4-HO-DMT), is a substituted tryptamine alkaloid and a serotonergic psychedelic. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocy ...

. The

pharmacodynamic Pharmacodynamics (PD) is the study of the biochemistry, biochemical and physiology, physiologic effects of drugs (especially pharmaceutical drugs). The effects can include those manifested within animals (including humans), microorganisms, or comb ...

profile of CYB003, including its interactions with

serotonin receptor 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in multiple tissues including the central and peripheral nervous systems. They mediate both ex ...

s and its effects in animals, is similar to that of psilocin. As with psilocin, CYB003 is a potent

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

of the

serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ...

5-HT_2A receptor and produces psychedelic-like effects in animals. However, it was developed to have improved

pharmacokinetic Pharmacokinetics (from Ancient Greek ''pharmakon'' "drug" and ''kinetikos'' "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to describing how the body affects a specific subs ...

properties compared to psilocybin, including reduced variability in circulating levels, a faster

onset of action Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration, it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question. Other meth ...

, and a shorter duration. As of October 2024, CYB003 is in phase 3

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...

s for major depressive disorder and is in the preclinical stage of development for alcoholism and other psychiatric disorders. Two phase 3 clinical trials for major depressive disorder are being initiated in November 2024 and February 2025. The drug is under development by

Cybin Cybin IRL is a Canadian pharmaceutical company that is developing psychedelic drugs as medicines. The company's drug candidates include psilocybin (CYB001), CYB002 (discontinued), CYB003 ( deuterated psilocin), CYB004 (deuterated dimethyltrypta ...

. The

chemical structure A chemical structure of a molecule is a spatial arrangement of its atoms and their chemical bonds. Its determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target m ...

of CYB003 has not yet been disclosed. However, Cybin

patent A patent is a type of intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an sufficiency of disclosure, enabling discl ...

ed deuterated tryptamines including the dideuterated psilocin analogue PI-α,α-d₂ (

dideuterated at the α carbon) in 2023. Other related drugs include the deuterated tryptamine

CYB004 CYB004, or CYB-004, also known as deuterated dimethyltryptamine (dDMT), is a serotonergic psychedelic related to dimethyltryptamine (DMT) which is under development for the treatment of generalized anxiety disorder. It is administered by inhalat ...

, the deuterated

phenethylamine Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace ami ...

CYB005 CYB005, or CYB-005, also known as deuterated phenethylamine derivative, is a serotonin receptor agonist and serotonergic psychedelic which is under development for use at non-hallucinogenic doses in the treatment of psychiatric disorders and neur ...

, and the phenethylamine

CYB210010 CYB210010, also known as 2C-T-TFM or 2C-T-36 and as 2,5-dimethoxy-4-(trifluoromethylsulfanyl)phenethylamine, is a lesser-known psychedelic drug of the phenethylamine family related to compounds such as 2C-T and 2C-T-21. Alexander Shulgin atte ...

. An of ''deupsilocin'' for a deuterated form of psilocin called d₁₀-psilocin with CAS number 1435934-64-7 was proposed in 2023 and recommended in 2024.deupsilocinum deupsilocin 3- -(²H₄)ethyl1''H''-indol-4-ol psychodysleptic ..C₁₂H₆²H₁₀N₂O 1435934-64-7 https://www.who.int/docs/default-source/international-nonproprietary-names-(inn)/pl129.pdf#page=35deupsilocinum deupsilocin 3- -(²H₄)ethyl1''H''-indol-4-ol ..C₁₂H₆²H₁₀N₂O https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-%28inn%29/rl91.pdf This deuterated analogue of psilocin was

ed in 2021 by Lennham Pharmaceuticals. It is said to be in phase 3 trials.

References

External links

CYB003 – Cybin
{{Tryptamines 5-HT2A agonists Deuterated compounds N,N-Dialkyltryptamines Drugs with undisclosed chemical structures Experimental antidepressants Experimental hallucinogens Experimental psychiatric drugs 4-Hydroxytryptamines Psychedelic tryptamines Serotonin receptor agonists

See also

References

External links