CTW0404 is an experimental drug which is described as a positive

allosteric modulator In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli. Some of them, like benzodiazepines or alcohol, function as psychoactive drugs. The site that a ...

of the 5-HT_2A receptor, with neutral or negative modulation of the related 5-HT_2B and 5-HT_2C subtypes. It does not produce the

head-twitch response The head-twitch response (HTR), also sometimes known as wet dog shakes (WDS) in rats, is a rapid side-to-side head movement that occurs in mice and rats in association with serotonin 5-HT2A receptor activation. Serotonergic psychedelics like lys ...

in animal studies, and reduces the head-twitch response produced by DOI, suggesting that it may be a biased allosteric modulator selective for certain signalling pathways.

References

5-HT2A receptor positive allosteric modulators Experimental drugs Piperidines Morpholines Phenyl compounds Carboxamides {{pharm-stub

See also

References