CREB regulated transcription coactivator 2, also known as CRTC2, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
which in humans is encoded by the CRTC2
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
CRTC2, initially called TORC2, is a transcriptional
coactivator for the transcription factor
CREB
CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first de ...
and a central regulator of
gluconeogenic gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. ...
in response to
cAMP.
CRTC2 is thought to drive tumorigenesis in LKB11/STK11-null non-small cell lung cancers (
NSCLC
Non-small-cell lung cancer (NSCLC) is any type of epithelial lung cancer other than small-cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitive to chemotherapy, compared to sm ...
).
Interactions
CRTC2 has been shown to
interact
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with
SNF1LK2 and
YWHAQ.
References
Further reading
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External links
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Gene expression
Transcription coregulators
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