CCR4-NOT transcription complex subunit 7 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''CNOT7''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
It is a subunit of the
CCR4-Not deadenylase complex.
Function
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Interactions
CNOT7 has been shown to
interact with:
*
BTG1
Protein BTG1 is a protein that in humans is encoded by the ''BTG1'' gene.
Function
The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a mem ...
,
*
PABPC1,
[
* TOB1,][ and
* ]TOB2
Protein Tob2 is a protein that in humans is encoded by the ''TOB2'' gene.
TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression. uppl ...
.
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
External links
*
*
{{gene-8-stub