Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an
interleukin receptor
Interleukin receptors are a family of cytokine receptors for interleukins. They belong to the immunoglobulin superfamily.
Types
There are two main families of Interleukin receptors, Type 1 and Type 2.
Type 1
Type 1 interleukin receptors includ ...
. IL1R1 also denotes its human
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
The protein encoded by this gene is a cytokine receptor that belongs to the
interleukin-1 receptor
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1. Two forms of the receptor exist. The type I Type 1 or Type I or ''variant'', may refer to:
Health
*Diabetes mellitus type 1 (also known as "Type 1 Diabetes"), i ...
family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
Interactions
Interleukin 1 receptor, type I has been shown to
interact
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with
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the ''PIK3R1'' gene.
Function
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Th ...
,
and
IL1RAP
Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the ''IL1RAP'' gene.
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at ...
.
See also
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Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophen ...
*
Interleukin 1 receptor, type II
Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.
Function
The protein encoded by this gene is a decoy receptor for certain cytokines ...
References
Further reading
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External links
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Clusters of differentiation
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