Brian Kuhlman
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Brian A. Kuhlman is an American professor of
biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...
and
biophysics Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations ...
at the
UNC School of Medicine The University of North Carolina School of Medicine is the medical school of the University of North Carolina at Chapel Hill. It offers a Doctor of Medicine degree, along with combined Doctor of Medicine with Doctor of Philosophy degree and Doctor ...
of
University of North Carolina at Chapel Hill The University of North Carolina at Chapel Hill (UNC, UNC–Chapel Hill, or simply Carolina) is a public university, public research university in Chapel Hill, North Carolina, United States. Chartered in 1789, the university first began enrolli ...
and a Sloan Research Fellow.


Early life

Kuhlman obtained Bachelor of Arts degree in
chemical physics Chemical physics is a branch of physics that studies chemical processes from a physical point of view. It focuses on understanding the physical properties and behavior of chemical systems, using principles from both physics and chemistry. This ...
from
Rice University William Marsh Rice University, commonly referred to as Rice University, is a Private university, private research university in Houston, Houston, Texas, United States. Established in 1912, the university spans 300 acres. Rice University comp ...
in 1992. From 1993 to 1998 he studied under guidance of Daniel Raleigh to earn his Ph.D. in
chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules a ...
from
Stony Brook University Stony Brook University (SBU), officially the State University of New York at Stony Brook, is a public university, public research university in Stony Brook, New York, United States, on Long Island. Along with the University at Buffalo, it is on ...
and from 1999 to 2002 he studied under guidance from David Baker to obtain Damon Runyon Postdoctoral Fellowship at the
University of Washington The University of Washington (UW and informally U-Dub or U Dub) is a public research university in Seattle, Washington, United States. Founded in 1861, the University of Washington is one of the oldest universities on the West Coast of the Uni ...
.


Career

In 2003, Kuhlman designed the first full-domain artificial protein,
Top7 Top7 is an artificial protein, classified as a ''de novo'' protein. This means that the protein itself was designed to have a specific structure and functional properties. Background Top7 was designed by Brian Kuhlman and Gautam Dantas in D ...
, with Gautam Dantas and other researchers, in David Baker's laboratory. In his independent research laboratory, Kuhlman continued pioneering research in
protein design Protein design is the rational design of new protein molecules to design novel activity, behavior, or purpose, and to advance basic understanding of protein function. Proteins can be designed from scratch (''de novo'' design) or by making calcul ...
, including breakthroughs in design of protein conformational switches, protein interface design, design of protein loops, stitching together components of natural proteins, designed fusions for bispecific antibodies, and progress toward vaccines.


Awards

*
DeLano Award for Computational Biosciences The DeLano Award for Computational Biosciences is a prize in the field of computational biology. It is awarded annually for "the most accessible and innovative development or application of computer technology to enhance research in the life scienc ...
*
Feynman Prize in Nanotechnology The Feynman Prize in Nanotechnology is an award given by the Foresight Institute for significant advances in nanotechnology. Two prizes are awarded annually, in the categories of experimental and theoretical work. There is also a separate challe ...
* Beckman Young Investigator


References


External links

* Living people American biochemists American biophysicists Rice University alumni Stony Brook University alumni University of Washington alumni Sloan Research Fellows University of North Carolina at Chapel Hill faculty Year of birth missing (living people) {{US-biochemist-stub