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David Baker (biochemist)
David Baker (born October 6, 1962) is an American biochemist and computational biology, computational biologist who has pioneered methods to Protein design, design proteins and protein structure prediction, predict their three-dimensional structures. He is the Henrietta and Aubrey Davis Endowed Professor in Biochemistry, an investigator with the Howard Hughes Medical Institute, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington. He was awarded the shared 2024 Nobel Prize in Chemistry for his work on computational protein design. Baker is a member of the United States National Academy of Sciences and the director of the University of Washington's Institute for Protein Design. He has co-founded more than a dozen biotechnology companies and was included in Time (magazine), ''Time'' magazine's inaugural list of the 100 Most Influential People in health in 2024. Biography Early life and ed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seattle
Seattle ( ) is the most populous city in the U.S. state of Washington and in the Pacific Northwest region of North America. With a population of 780,995 in 2024, it is the 18th-most populous city in the United States. The city is the county seat of King County, the most populous county in Washington. The Seattle metropolitan area's population is 4.02 million, making it the 15th-most populous in the United States. Its growth rate of 21.1% between 2010 and 2020 made it one of the country's fastest-growing large cities. Seattle is situated on an isthmus between Puget Sound, an inlet of the Pacific Ocean, and Lake Washington. It is the northernmost major city in the United States, located about south of the Canadian border. A gateway for trade with East Asia, the Port of Seattle is the fourth-largest port in North America in terms of container handling . The Seattle area has been inhabited by Native Americans (such as the Duwamish, who had at least 17 villages a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Overton Prize
The ISCB Overton Prize is a computational biology prize awarded annually for outstanding accomplishment by a scientist in the early to mid stage of his or her career. Laureates have made significant contribution to the field of computational biology either through research, education, service, or a combination of the three. The prize was established by the International Society for Computational Biology (ISCB) in memory of a major contributor to the field of bioinformatics and member of the ISCB Board of Directors who died unexpectedly in 2000. The Overton Prize is traditionally awarded at the Intelligent Systems for Molecular Biology (ISMB) conference. Laureates Laureates include *2024 - *2023 - *2022 - *2021 - Barbara Engelhardt *2020 - *2019 - Christophe Dessimoz *2018 - Cole Trapnell *2017 - Christoph Bock *2016 - Debora Marks *2015 - Curtis Huttenhower *2014 - Dana Pe'er *2013 - Gonçalo Abecasis *2012 - Ziv Bar-Joseph *2011 - Olga Troyanskaya *2010 - Steven ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Time (magazine)
''Time'' (stylized in all caps as ''TIME'') is an American news magazine based in New York City. It was published Weekly newspaper, weekly for nearly a century. Starting in March 2020, it transitioned to every other week. It was first published in New York City on March 3, 1923, and for many years it was run by its influential co-founder, Henry Luce. A European edition (''Time Europe'', formerly known as ''Time Atlantic'') is published in London and also covers the Middle East, Africa, and, since 2003, Latin America. An Asian edition (''Time Asia'') is based in Hong Kong. The South Pacific edition, which covers Australia, New Zealand, and the Pacific Islands, is based in Sydney. Since 2018, ''Time'' has been owned by Salesforce founder Marc Benioff, who acquired it from Meredith Corporation. Benioff currently publishes the magazine through the company Time USA, LLC. History 20th century ''Time'' has been based in New York City since its first issue published on March 3, 1923 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field in the United States. Members of the National Academy of Sciences serve '' pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Congress legislated and President Abraham Lincoln signed an Act of Congress (1863) establishing the National Academy of Sciences as an independent, trusted nongovernmental institution, created for the purpose of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Design
Protein design is the rational design of new protein molecules to design novel activity, behavior, or purpose, and to advance basic understanding of protein function. Proteins can be designed from scratch (''de novo'' design) or by making calculated variants of a known protein structure and its sequence (termed ''protein redesign''). Rational protein design approaches make protein-sequence predictions that will fold to specific structures. These predicted sequences can then be validated experimentally through methods such as peptide synthesis, site-directed mutagenesis, or artificial gene synthesis. Rational protein design dates back to the mid-1970s. Recently, however, there were numerous examples of successful rational design of water-soluble and even transmembrane peptides and proteins, in part due to a better understanding of different factors contributing to protein structure stability and development of better computational methods. Overview and history The goal in ratio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Structure Prediction
Protein structure prediction is the inference of the three-dimensional structure of a protein from its amino acid sequence—that is, the prediction of its Protein secondary structure, secondary and Protein tertiary structure, tertiary structure from Protein primary structure, primary structure. Structure prediction is different from the inverse problem of protein design. Protein structure prediction is one of the most important goals pursued by computational biology and addresses Levinthal's paradox. Accurate structure prediction has important applications in medicine (for example, in drug design) and biotechnology (for example, in novel enzyme design). Starting in 1994, the performance of current methods is assessed biannually in the ''Critical Assessment of Structure Prediction'' (CASP) experiment. A continuous evaluation of protein structure prediction web servers is performed by the community project ''Continuous Automated Model EvaluatiOn'' (CAMEO3D). Protein structure a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Computational Biology
Computational biology refers to the use of techniques in computer science, data analysis, mathematical modeling and Computer simulation, computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and data science, the field also has foundations in applied mathematics, molecular biology, cell biology, chemistry, and genetics. History Bioinformatics, the analysis of informatics processes in biological systems, began in the early 1970s. At this time, research in artificial intelligence was using network models of the human brain in order to generate new algorithms. This use of biological data pushed biological researchers to use computers to evaluate and compare large data sets in their own field. By 1982, researchers shared information via Punched card, punch cards. The amount of data grew exponentially by the end of the 1980s, requiring new computational methods for quickly interpreting relevant information. Per ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemist
Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of "biological chemist." Biochemists also research how certain chemical reactions happen in cells and Tissue (biology), tissues and observe and record the effects of Product (chemistry), products in food additives and Medication, medicines. Biochemist researchers focus on playing and constructing research experiments, mainly for developing new products, updating existing products and analyzing said products. It is also the responsibility of a biochemist to present their research findings and create Grant writing, grant proposals to obtain Funding of science, funds for future research. Biochemists study aspects of the immune system, the expressions of genes, isolating, analyzing, and synthesizing different products, mutations that lead to ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hannele Ruohola-Baker
Hannele Ruohola-Baker (born December 10, 1959) is a Finnish biochemist. She is a professor of biochemistry and associate director of the Institute for Stem Cell and Regenerative Medicine at the University of Washington in Seattle, Washington. Her research focuses on the molecular biology of stem cells and on the use of ''Drosophila'' (fruit flies) as model organisms for human diseases. Early life and education Ruohola-Baker was born in the small village of Kullaa, Finland, in 1959. She received her bachelor's and master's degree from the University of Helsinki and received her Ph.D. in cell biology from Yale University in 1989, studying cellular transport and advised by Susan Ferro-Novick. She then moved to a visiting fellowship at the Ludwig Institute for Cancer Research at the Karolinska Institute in Stockholm and subsequently to a postdoctoral fellowship at the University of California, San Francisco with Yuh Nung and Lily Jan. Academic career Ruohola-Baker began her facul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Chemistry
The Nobel Prize in Chemistry () is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outstanding contributions in chemistry, physics, literature, peace, and physiology or medicine. This award is administered by the Nobel Foundation and awarded by the Royal Swedish Academy of Sciences on proposal of the Nobel Committee for Chemistry, which consists of five members elected by the Academy. The award is presented in Stockholm at an annual ceremony on December 10th, the anniversary of Nobel's death. The first Nobel Prize in Chemistry was awarded in 1901 to Jacobus Henricus van 't Hoff, of the Netherlands, "for his discovery of the laws of chemical dynamics and osmotic pressure in solutions". From 1901 to 2024, the award has been bestowed on a total of 195 individuals. The 2024 Nobel Prize in Chemistry was awarded to Demis Hassabis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BBVA Foundation Frontiers Of Knowledge Award
The BBVA Foundation Frontiers of Knowledge Awards () are an international award programme recognizing significant contributions in the areas of scientific research and cultural creation. The categories that make up the Frontiers of Knowledge Awards respond to the knowledge map of the present age. As well as the fundamental knowledge that is at their core, they address developments in information and communication technologies, and interactions between biology and medicine, ecology and conservation biology, climate change, economics, humanities and social sciences, and, finally, contemporary musical creation and performance. Specific categories are reserved for developing knowledge fields of critical relevance to confront central challenges of the 21st century, as in the case of the two environmental awards. The awards were established in 2008, with the first set of winners receiving their prizes in 2009. The BBVA Foundation – belonging to financial group BBVA – is partnered in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wiley Prize
The Wiley Prize in Biomedical Sciences is intended to recognize breakthrough research in pure or applied life science research that is distinguished by its excellence, originality and impact on our understanding of biological systems and processes. The award may recognize a specific contribution or series of contributions that demonstrate the nominee's significant leadership in the development of research concepts or their clinical application. Particular emphasis will be placed on research that champions novel approaches and challenges accepted thinking in the biomedical sciences. The Wiley Foundation, established in 2001, is the endowing body that supports the Wiley Prize in Biomedical Sciences. This international award is presented annually and consists of a $35,000 prize and a luncheon in honor of the recipient. The award is presented at a ceremony at The Rockefeller University, where the recipient delivers an honorary lecture as part of the Rockefeller University Lecture Seri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
