Bertram Oliver "Bert" Fraser-Reid (23 February 1934 – 25 May 2020) was a Jamaican synthetic
organic chemist
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; ...
who has been widely recognised for his work using
carbohydrates
In organic chemistry, a carbohydrate () is a biomolecule consisting of carbon (C), hydrogen (H) and oxygen (O) atoms, usually with a hydrogen–oxygen atom ratio of 2:1 (as in water) and thus with the empirical formula (where ''m'' may or may ...
as starting materials for
chiral
Chirality is a property of asymmetry important in several branches of science. The word ''chirality'' is derived from the Greek (''kheir''), "hand", a familiar chiral object.
An object or a system is ''chiral'' if it is distinguishable from i ...
materials and on the role of
oligosaccharides
An oligosaccharide (/ˌɑlɪgoʊˈsækəˌɹaɪd/; from the Greek ὀλίγος ''olígos'', "a few", and σάκχαρ ''sácchar'', "sugar") is a saccharide polymer containing a small number (typically two to ten) of monosaccharides (simple sug ...
in
immune response
An immune response is a reaction which occurs within an organism for the purpose of defending against foreign invaders. These invaders include a wide variety of different microorganisms including viruses, bacteria, parasites, and fungi which could ...
.
Early life
Fraser-Reid was born in
Coleyville,
Jamaica
Jamaica (; ) is an island country situated in the Caribbean Sea. Spanning in area, it is the third-largest island of the Greater Antilles and the Caribbean (after Cuba and Hispaniola). Jamaica lies about south of Cuba, and west of Hispan ...
to William, an elementary school principal, and Laura, a teacher.
He had five older siblings.
Laura died when Fraser-Reid was only nine months old.
He attended
Excelsior High School and
Clarendon College before moving to
Canada
Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by tota ...
to earn BSc (1959) and MSc (1961) at
Queen's University in
Ontario
Ontario ( ; ) is one of the thirteen provinces and territories of Canada.Ontario is located in the geographic eastern half of Canada, but it has historically and politically been considered to be part of Central Canada. Located in Central C ...
He went to
University of Alberta
The University of Alberta, also known as U of A or UAlberta, is a public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford,"A Gentleman of Strathcona – Alexander Cameron Ruth ...
to earn a PhD in 1964
under the supervision of
Raymond Lemieux
Raymond Urgel Lemieux, CC, AOE, FRS (June 16, 1920 – July 22, 2000) was a Canadian organic chemist, who pioneered many discoveries in the field of chemistry, his first and most famous being the synthesis of sucrose. His contributions includ ...
. He went to
Imperial College London
Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a ...
to do
postdoctoral
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...
work for Nobel Laureate
Sir Derek Barton from 1964 to 1966.
Academic career
From 1966 to 1980 Fraser-Reid was on the faculty of the
University of Waterloo
The University of Waterloo (UWaterloo, UW, or Waterloo) is a public research university with a main campus in Waterloo, Ontario, Canada. The main campus is on of land adjacent to "Uptown" Waterloo and Waterloo Park. The university also operates ...
in
Waterloo, Ontario
Waterloo is a city in the Canadian province of Ontario. It is one of three cities in the Regional Municipality of Waterloo (formerly Waterloo County). Waterloo is situated about west-southwest of Toronto. Due to the close proximity of the c ...
where he established a research group known as "Fraser-Reid's Rowdies".
The primary emphasis of his work at this point was the synthesis of
chiral
Chirality is a property of asymmetry important in several branches of science. The word ''chirality'' is derived from the Greek (''kheir''), "hand", a familiar chiral object.
An object or a system is ''chiral'' if it is distinguishable from i ...
natural products using
carbohydrates
In organic chemistry, a carbohydrate () is a biomolecule consisting of carbon (C), hydrogen (H) and oxygen (O) atoms, usually with a hydrogen–oxygen atom ratio of 2:1 (as in water) and thus with the empirical formula (where ''m'' may or may ...
as the starting materials. In 1975, Fraser-Reid was the first to publish a method for making nonsugar compounds with simple sugars.
In 1980, he was hired at the
University of Maryland, College Park
The University of Maryland, College Park (University of Maryland, UMD, or simply Maryland) is a public land-grant research university in College Park, Maryland. Founded in 1856, UMD is the flagship institution of the University System of ...
,
and then at
Duke University in
North Carolina
North Carolina () is a state in the Southeastern region of the United States. The state is the 28th largest and 9th-most populous of the United States. It is bordered by Virginia to the north, the Atlantic Ocean to the east, Georgia a ...
in 1983.
In 1985 he was appointed the
James B. Duke Professor of Chemistry.
At Duke University, his research shifted to exploring the role of
oligosaccharides
An oligosaccharide (/ˌɑlɪgoʊˈsækəˌɹaɪd/; from the Greek ὀλίγος ''olígos'', "a few", and σάκχαρ ''sácchar'', "sugar") is a saccharide polymer containing a small number (typically two to ten) of monosaccharides (simple sug ...
in immune responses, and particularly on the effect of molecules on human diseases like
malaria
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or deat ...
and
AIDS. After retiring from Duke in 1996, due to an undisclosed harassment claim, he established the Natural Products & Glycotechnology Research Institute, a nonprofit, to study the carbohydrate chemistry/biology of tropical
parasitic diseases
A parasitic disease, also known as parasitosis, is an infectious disease caused by parasites. Parasites are organisms which derive sustenance from its host while causing it harm. The study of parasites and parasitic diseases is known as parasitol ...
in developing countries and to develop a carbohydrate-based
malaria vaccine
A malaria vaccine is a vaccine that is used to prevent malaria. The only approved use of a vaccine outside the EU, as of 2022, is RTS,S, known by the brand name ''Mosquirix''. In October 2021, the WHO for the first time recommended the large-sc ...
.
Fraser-Reid and his team achieved a milestone in oligosaccharide synthesis by assembling a molecule consisting of 28
monosaccharide
Monosaccharides (from Greek '' monos'': single, '' sacchar'': sugar), also called simple sugars, are the simplest forms of sugar and the most basic units (monomers) from which all carbohydrates are built.
They are usually colorless, water-sol ...
units.
Achievements
Several sources have reported that Fraser-Reid was nominated in 1998 for a Nobel Prize in chemistry for his work on oligosaccharides and immune responses.
This statement cannot be verified since the names of the nominees are never publicly announced, and neither are they told that they have been considered for the Prize.
Nomination records are sealed for fifty years.
The
Institute of Jamaica
The Institute of Jamaica (IOJ), founded in 1879, is the country's most significant cultural, artistic and scientific organisation:[Musgrave Medal
The Musgrave Medal is an annual award by the Institute of Jamaica in recognition of achievement in art, science, and literature.Webster, Valerie J. (2000), ''Awards, Honors & Prizes, Volume 2'', Gale Group, , p. 447. Originally conceived in 1889 a ...]
(Gold) for his work in chemistry, noting that during his career he co-authored over 330
peer-reviewed
Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work ( peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer revie ...
publications and supervised 85
post-doctoral fellows and 55 PhD students.
Other interests
Along with his interest in science, Fraser-Reid was an accomplished pianist and organist who gave recitals at notable venues such as St. George's Cathedral, Kingston, Jamaica (December 1986) and
Cathedral de Seville, Spain (August 1995).
In the 1970s Fraser-Reid filed a lawsuit against a building contractor who had not followed municipal building codes. The case went all the way to the
Supreme Court of Canada
The Supreme Court of Canada (SCC; french: Cour suprême du Canada, CSC) is the highest court in the judicial system of Canada. It comprises nine justices, whose decisions are the ultimate application of Canadian law, and grants permission to ...
where Fraser-Reid prevailed, and "Fraser-Reid v Droumtsekas" is often cited in
Canadian civil law.
See also
*
List of University of Waterloo people
The University of Waterloo, located in Waterloo, Ontario, Canada, is a comprehensive public university that was founded in 1957 by Drs. Gerry Hagey and Ira G. Needles. It has grown into an institution of more than 42,000 students, faculty, and st ...
References
{{DEFAULTSORT:Fraser-Reid, Bertram
1934 births
2020 deaths
Organic chemists
Jamaican academics
Emigrants from British Jamaica to Canada
Canadian chemists
University of Waterloo faculty
Duke University faculty
Recipients of the Musgrave Medal
Male organists
Queen's University at Kingston alumni
University of Alberta alumni
21st-century Canadian pianists
21st-century organists
21st-century chemists
21st-century Canadian male musicians
People from Manchester Parish